초록 ▼

The invention is provides a method and an apparatus for performing electrospray ionization mass spectrometric analysis, which method can exactly analyze a mass of a molecular ion or a fragment ion of an unstable organometallic complex or a polymeric organic compound. The method includes cooling a sa

The invention is provides a method and an apparatus for performing electrospray ionization mass spectrometric analysis, which method can exactly analyze a mass of a molecular ion or a fragment ion of an unstable organometallic complex or a polymeric organic compound. The method includes cooling a sample to be analyzed which contains a solvent and is caused to flow out from a spray small-diameter tube with an inert gas for low temperature vaporization (A), and carrying out ionization and mass spectrometric analysis of the sample to be analyzed while cooling a chamber (7) for removing a solvent or an ion source shield (8) with liquid nitrogen.

대표청구항 ▼

1. A method for performing electrospray mass spectrometric analysis, characterized by comprising atomizing a sample solution to be analyzed which contains a solvent and is caused to flow out from a small-diameter tube for spraying while the sample solution is cooled by means of a gas for vaporizatio

1. A method for performing electrospray mass spectrometric analysis, characterized by comprising atomizing a sample solution to be analyzed which contains a solvent and is caused to flow out from a small-diameter tube for spraying while the sample solution is cooled by means of a gas for vaporization; and ionizing the atomized sample solution to be analyzed while a chamber for removing a solvent and an ion source shield are cooled, to thereby perform mass spectrometric analysis of the sample. 2. A method for performing electrospray mass spectrometric analysis as described in claim 1, wherein the gas for vaporization and the ion source shield are maintained at low temperature within the range of liquid nitrogen temperature to room temperature. 3. A method for performing electrospray mass spectrometric analysis as described in claim 1, wherein the sample to be analyzed is an organic compound. 4. A method for performing electrospray mass spectrometric analysis as described in claim 1, wherein the gas for vaporization is a nebulizer gas. 5. A method for performing electrospray mass spectrometric analysis as described in claim 1, wherein the gas for vaporization is an inert gas such as nitrogen gas. 6. A method for performing electrospray ionization mass spectrometric analysis as described in claim 1, wherein water or a non-polar organic solvent (e.g., H2O, CH3CN, CHCl3) is used as the solvent, so as to perform molecular structure analysis. 7. An apparatus for performing electrospray mass spectrometric analysis, characterized by comprising (a) a small-diameter tube for spraying and for causing to flow out a sample solution to be analyzed containing a solvent; (b) a sheath tube which is co-axially provided with the tube for spraying and allows passage of a gas for cooling; (c) a chamber for removing a solvent and an ion source shield which are cooled; and (d) a mass spectrometer for ionizing by use of the solvent and performing mass analysis of a sample to be analyzed; (e) wherein an ion source formed through electrospraying is employed while the ion source is cooled by spraying liquid nitrogen directly to a chamber for removing a solvent and to an ion source shield. 8. An apparatus for performing electrospray mass spectrometric analysis as described in claim 7, wherein the gas for cooling is introduced into the sheath tube after treatment in an apparatus for cooling an inert gas.