[특허]Cardiac valve replacement

[미국특허] Cardiac valve replacement 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/24
출원번호	US-0828768 (2001-04-09)
발명자 / 주소	Hopkins, Richard A. Hoffman-Kim, Diane
출원인 / 주소	Rhode Island Hospital
대리인 / 주소	Beattie, Ingrid A.Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
인용정보	피인용 횟수 : 18 인용 특허 : 39

초록

The invention provides a replacement heart valve which contains an acellular matrix as a structural scaffold. The scaffold is seeded with isolated myofibroblasts and/or endothelial cells prior to implantation into a recipient mammal.

대표청구항 ▼

1. A bioprosthetic heart valve comprising an acellular matrix, isolated myofibroblasts, and isolated endothelial cells, wherein at least 60% of the total collagen produced by said myofibroblasts is type I collagen. 2. The valve of claim 1, wherein said myofibroblasts produce at least 2-fold greater type I collagen compared to type III collagen. 3. The valve of claim 1, wherein said myofibroblasts produce one or more extracellular matrix components selected from the group consisting of fibronectin, elastin, and glycosaminoglycan. 4. The valve of claim 3, wherein said glycosaminoglycan is chondroitin sulfate or hyaluronic acid. 5. The valve of claim 1, wherein an external layer of said valve comprises a monolayer of said endothelial cells and wherein an inner layer comprises said isolated myofibroblasts. 6. A valve comprising an acellular matrix, isolated myofibroblasts, and isolated endothelial cells, wherein less than 25% of total collagen production by said myofibroblasts is type III collagen. 7. The valve of claim 5, wherein less than 20% of total collagen production by said myofibroblast is type III collagen. 8. The valve of claim 5, wherein less than 15% of total collagen production by said myofibroblast is type III collagen. 9. The valve of claim 5, wherein said myofibroblast is derived from mammalian heart leaflet interstitial tissue. 10. The valve of claim 5, wherein said myofibroblasts is derived from a mammalian vascular or dermal tissue. 11. The valve of claim 5, wherein said myofibroblasts is derived from human heart leaflet interstitial tissue. 12. The valve of claim 5, wherein an external layer of said valve comprises a monolayer of said endothelial cells and wherein an inner layer comprises said isolated myofibroblasts. 13. A bioprosthetic heart valve comprising isolated myofibroblasts, wherein said myofibroblasts are genetically altered to increase type I collagen production relative to type III collagen production.

이 특허에 인용된 특허 (39) 인용/피인용 타임라인 분석

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Linner John G. (Woodlands TX) Livesey Stephen A. (Woodlands TX) Piunno Carmen (Woodlands TX) Zaltsberg Mark (Woodlands TX) Gibson Frank (Spring TX), Cryo-slammer.
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Linner John G. (The Woodlands TX) Livesey Stephen A. (The Woodlands TX), Cryo-slamming apparatus and method for ultrarapid cooling of biological samples.
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Livesey Stephen A. ; del Campo Anthony A. ; Nag Abhijit ; Nichols Ken B. ; Piunno Carmen ; Ross David P., Cryoprotective solutions comprising DMSO, PG, 2,3-butanediol,raffinose and PVP.
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Vacanti Joseph P. ; Breuer Christopher K. ; Chaignaud Beverly E. ; Shin'oka Toshiraru, Engineering of strong, pliable tissues.
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Robertson John Charles ; Moulder Brian W. ; Pedros Roberto, Heart valve replacement tools and procedures.
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Piunno Carmen (The Woodlands TX) Livesey Stephen (Victoria TX AUX) Linner John G. (The Woodlands TX) del Campo Anthony A. (Houston TX) Zaltzberg Mark J. (The Woodlands TX), Method and apparatus for cryopreparing biological tissue.
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Livesey Stephen A. (Eltham TX AUX) del Campo Anthony A. (Houston TX) Nag Abhijit (Houston TX) Nichols Ken B. (The Woodlands TX) Coleman Christopher (Houston TX), Method for processing and preserving collagen-based tissues for transplantation.
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Livesey Stephen A. (Victoria TX AUX) del Campo Anthony A. (Houston TX) Nag Abhijit (Houston TX), Method of cryopreserving a suspension of biological material.
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Vacanti Joseph P. ; Langer Robert S., Preparation of three-dimensional fibrous scaffold for attaching cells to produce vascularized tissue in vivo.
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Wolfinbarger ; Jr. Lloyd, Process and composition for cleaning soft tissue grafts optionally attached to bone and soft tissue and bone grafts produced thereby.
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Wolfinbarger ; Jr. Lloyd ; Ford Louis, Process for cleaning bone grafts using centrifugal force and bone grafts produced thereby.
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Wolfinbarger ; Jr. Lloyd, Process for cleaning large bone grafts and bone grafts produced thereby.
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Wolfinbarger Lloyd (Norfolk VA), Process for cleaning large bone grafts and bone grafts produced thereby.
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Wolfinbarger Lloyd (Norfolk VA) Bottenfield Scott (Virginia Beach VA), Process for demineralization of bone using column extraction.
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Livesey Stephen A. (Eltham AUX) Connor Jerome (Houston TX) Currie Laura M. (Houston TX), Prolonged preservation of blood platelets.
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Goldstein Steven ; Black Kirby S., Pulsatile flow system for developing heart valves.
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Wolfinbarger ; Jr. Lloyd, Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone gra.
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Naughton Gail K. (Groton VT) Naughton Brian A. (Groton VT), Three-dimensional cell and tissue culture system.
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Goldstein Steven, Treated tissue for implantation and methods of preparation.
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[미국특허] Cardiac valve replacement 원문보기