[특허]Sandwich assays for collagen type I fragments

[미국특허] Sandwich assays for collagen type I fragments 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/53
출원번호	US-0319539 (1999-06-08)
우선권정보	GB-19960025559 (1996-12-09); GB-19970005687 (1997-03-19)
국제출원번호	PCT/EP97/06803 (1997-12-05)
국제공개번호	WO98/26286 (1998-06-18)
발명자 / 주소	Rosenquist, Christian Qvist, Per
출원인 / 주소	Osteometer Biotech A/S
대리인 / 주소	Pennie & Edmonds LLP
인용정보	피인용 횟수 : 4 인용 특허 : 18

초록

Sandwich assays for collagen degradation products are conducted using an antibody of the same specificity on both sides of the sandwich or using a first antibody reactive with an epitope contained in the sequence EKAHDGGR and a second antibody which may be the same or different.

대표청구항 ▼

1. A method of measurement of the rate of type I collagen resorption comprising measuring in a sample the amount of a population of collagen fragments by a sandwich assay using a first antibody reactive with a first epitope located in the collagen amino acid sequence EKAHDGGR (SEQ. ID NO:1) or in isomerised and/or racemised variants thereof and a second antibody reactive with a second epitope, wherein the first and second epitopes are located in the same fragment. 2. The method of claim 1, wherein said second epitope is located in the N-terminal direction with respect to said first epitope. 3. The method of claim 2, wherein the second epitope comprises the amino acid sequence FDFSF (SEQ. ID NO: 8). 4. The method of claim 1, wherein the assay is a sandwich radio-immune assay or a sandwich ELISA assay. 5. The method of claim 1, wherein the molecular weight of fragments detected in the assay exceeds 1500 Da. 6. The method of claim 5, wherein the molecular weight of fragments detected in the assay exceeds 2500 Da. 7. A method of measurement of the rate of type I collagen resorption comprising measuring in a sample the amount of a population of collagen fragments by a sandwich assay using a first antibody reactive with a first epitope located in a first occurrence of the collagen amino acid sequence EKAHDGGR (SEQ. ID NO: 1) or in isomerised and/or racemised variants thereof and a second antibody reactive with a second epitope located in second occurrence of the amino acid sepuence EKAHDGGR (SEQ. ID NO: 1) or in isomerised and/or racemised variants thereof, wherein the first and ssecond epitooes are located in the same fragment. 8. The method of claim 7, wherein said epitope is present in a respective amino acid attached to a crosslink. 9. The method of claim 7, wherein said epitope is located in the amino acid sequence EKAH-βD-GGR (SEQ. ID NO:5). 10. The method of claim 9, wherein each antibody is a monoclonal antibody raised against a peptide analogue containing amino acid sequence EKAH-βD-GGR (SEQ. ID NO:5).

이 특허에 인용된 특허 (18) 인용/피인용 타임라인 분석

Eyre David R. (Mercer Island WA), Antibody to type-I collagen amino-terminal telopeptide.
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Eyre David R. (Mercer Island WA), Antigen-binding fragments of an antibody to type-I collagen amino-terminal telopeptide.
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Eyre David R. (Mercer Island WA), Assay for N-terminal type I collagen telopeptide that survives bone resorption in vivo.
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Eyre David R. (Mercer Island WA), Detection of collagen degradation in vivo.
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Eyre, David R., Detection of collagen degradation in vivo.
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Eyre David R. (Mercer Island WA), Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide.
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Naser Werner,DEX ; Drager Brigitte,DEX ; Essig Ulrich,DEX ; Hubner-Parajsz Christa,DEX ; Huber Erasmus,DEX, Hybridoma for producing antibody for collagen I.
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David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
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Eyre David R. (Mercer Island WA), Method of detecting collagen degradation in vivo.
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Heinegrd Dick K. (Lund SEX) Lindblad Gert (Upsala SEX), Method of monitoring the progressive destruction of articular cartilage in a joint.
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Eyre David R. (Mercer Island WA), Methods of detecting collagen degradation in vivo.
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Brocks Dietrich (Wiesbaden DEX) Punter Jurgen (Hofheim am Taunus DEX) Strecker ; deceased Helmut (late of Pfungstadt DEX by Renate Strecker ; heir ) Timpl Rupert (Gauting DEX) Gunzler-Pukall Volkmar , Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procoll.
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Taylor Diane W. (Potomac MD), Monoclonal antibodies to a pan-malarial antigen.
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Eyre David R. (Mercer Island WA), Peptide fragments containing HP and LP cross-links.
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Eyre David R. (Mercer Island WA), Peptide fragments containing HP and LP cross-links.
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Timpl Rupert (Gauting DEX) Brocks Dietrich (Hnfelden DEX) Neubauer Horst (Knigstein DEX) Strecker Helmut (Pfungstadt DEX), Procedure for immunologic determination of procollagen peptide (type III) and procollagen peptide col 1 (type III) toget.
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Timpl Rupert (Krailling DEX), Radioimmunological determination of procollagen (type III) and procollagen peptide (type III).
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Gay Steffen (Birmingham AL), Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins.
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이 특허를 인용한 특허 (4) 인용/피인용 타임라인 분석

Dordick, Jonathan S.; Clark, Douglas S., Biocatalytic solgel microarrays.
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Dordick,Jonathan S.; Clark,Douglas S., Biocatalytic solgel microarrays.
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Fertala, Andrzej; Steplewski, Andrzej, Engineered antibody for inhibition of fibrosis.
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Rosenquist,Christian; Qvist,Per; Christgau,Stephan, Sandwich assays for collagen fragments.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Sandwich assays for collagen type I fragments 원문보기