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Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, with each nozzle surrounded by an a

Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, with each nozzle surrounded by an annular gas flow outlet. Crosslinkable solutions are stored in separate compartments and communicated under pressure to the spray nozzles. In the presence of gas flow through the annular gas flow outlets, the crosslinkable solutions are atomized and mixed in the gas flow to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.

대표청구항 ▼

Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, with each nozzle surrounded by an a

Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, with each nozzle surrounded by an annular gas flow outlet. Crosslinkable solutions are stored in separate compartments and communicated under pressure to the spray nozzles. In the presence of gas flow through the annular gas flow outlets, the crosslinkable solutions are atomized and mixed in the gas flow to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described. and an enlarged guard section, said guard section having an area of 1.0 square inch or more, an edge, and an underside with a depression having a configuration substantially the same as the configuration of the medical device, so that when the guard section overlies the implanted medical device and is pressed against said implanted medical device, the skin of the patient and at least a portion of the medical device are received in said depression, an elongated slot which extends from the edge of said guard section and terminates in the guard section at in an enlarged open portion through which a needle is inserted when accessing the implanted medical device. 18. The tool of claim 17 where the enlarged open portion has an area in excess of 0.0036 square inch. 19. The tool of claim 17 where there is indicia at least partially encompassing the enlarged open portion which assist the nurse to align the open portion with the implanted medical device. 20. The tool of claim 17 where the handle has a connector section that is attached to the guard section, with said connector section and guard section form an angle of 60 degrees or more. 21. The tool of claim 20 where the angle is between 60 and 90 degrees. 22. A method for manually removing a needle from a medical device implanted under the skin of a patient, including grasping with one hand a handle section of a tool having a guard section having an area of 1.00 square inch or more and a slot therein, sliding the slot along the needle to bring the guard section into an overlying relationship with the implanted medical device, maintaining said one hand a minimum distance away from the needle of at least 2.5 inches, and with the other hand withdrawing said needle free of the implanted medical device. 23. The method of claim 22 where the guard section is made of a transparent material. 24. The method of claim 22 where the tool includes an elongated body having the handle section attached to the guard section, said guard section having a forward edge terminating at opposed ends, side edges at each opposed end which extend rearward to said handle section, and an elongated slot which extends from the forward edge rearward towards said handle section, said forward edge having a length of from 1 to 6 inches, said side edges having a length of from 0.5 to 3 inches, and said slot having a length of from 0.25 to 3 inches. 25. The method of claim 22 where said slot has a width that is slightly broader than the diameter of the needle. 26. The method of claim 22 where the tool has an elongated body having a length of from 4 to 11 inches, said body including the handle section having a length of from 3 to 8 inches and an enlarged guard section having a length of from 0.5 to 3 inches, said guard section having a forward edge having a length of from 1 to 6 inches, said forward edge terminating at opposed ends in side edges which extend rearward to said handle section, said side edges having a length of from 0.5 to 3 inches, an elongated slot in the guard section which extends from the forward edge rearward towards said handle section and has a width of from 1/16 to 1/4 inch and a length of from 0.25 to 3 inches, said slot being at a right angle with respect to the forward edge, with the slot and the handle section being in substantial alignment with each other, both lying along a common longitudinal axis, the minimum distance between said slot and the side edges being 3/16 inch and the maximum distance between the slot and the side edges being 3 inch. 27. A method for manually inserting a needle into a medical device implanted under the skin of a patient, including (a) grasping with one hand a tool with a holder section and a handle section, and holding the tool by the handle section and pressing the holder section against the skin overlying the medical device, (b) gripping the needle with the other hand and inserting said needle through said skin into the medical devi