IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
|
출원번호 |
US-0853478
(2001-05-11)
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발명자
/ 주소 |
|
출원인 / 주소 |
- The Regents of the University of Michigan
|
대리인 / 주소 |
Dierker & Glassmeyer, P.C.
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인용정보 |
피인용 횟수 :
61 인용 특허 :
6 |
초록
▼
3-D biodegradable porous, polymer (natural or synthetic) scaffolds with well-controlled, interconnected pores, and method for forming the porous materials. Hydrophilic and/or hydrophobic porogen materials were fabricated into 3-D negative replicas of the desired macroporous architectures. Biodegrada
3-D biodegradable porous, polymer (natural or synthetic) scaffolds with well-controlled, interconnected pores, and method for forming the porous materials. Hydrophilic and/or hydrophobic porogen materials were fabricated into 3-D negative replicas of the desired macroporous architectures. Biodegradable polymers (PLLA and PLGA) were dissolved in a solvent and cast onto the negative replica. After dissolving/leaching out the porogen materials, a porous polymer scaffold was formed. The skeletal structure of PLLA foams consisted of small platelets or nano-fibers, while PLGA foams had homogeneous skeletal structure. To improve the cell seeding, distribution, mass transport, and new tissue organization and vascularization, 3-D macroporous architectures are built in the nano-fibrous matrices. The method tailors polymer scaffolds for a variety of potential tissue engineering applications due to the well-controlled architecture, inter-pore connectivity, and mechanical properties.
대표청구항
▼
3-D biodegradable porous, polymer (natural or synthetic) scaffolds with well-controlled, interconnected pores, and method for forming the porous materials. Hydrophilic and/or hydrophobic porogen materials were fabricated into 3-D negative replicas of the desired macroporous architectures. Biodegrada
3-D biodegradable porous, polymer (natural or synthetic) scaffolds with well-controlled, interconnected pores, and method for forming the porous materials. Hydrophilic and/or hydrophobic porogen materials were fabricated into 3-D negative replicas of the desired macroporous architectures. Biodegradable polymers (PLLA and PLGA) were dissolved in a solvent and cast onto the negative replica. After dissolving/leaching out the porogen materials, a porous polymer scaffold was formed. The skeletal structure of PLLA foams consisted of small platelets or nano-fibers, while PLGA foams had homogeneous skeletal structure. To improve the cell seeding, distribution, mass transport, and new tissue organization and vascularization, 3-D macroporous architectures are built in the nano-fibrous matrices. The method tailors polymer scaffolds for a variety of potential tissue engineering applications due to the well-controlled architecture, inter-pore connectivity, and mechanical properties. 66, 19860300, Baskerville et al.; US-4586996, 19860500, Shinohara et al.; US-4594288, 19860600, Dobigny et al.; US-4613656, 19860900, Tang; US-4622376, 19861100, Misura et al.; US-4623497, 19861100, Waters; US-4640489, 19870200, Larsen; US-4720356, 19880100, Chu; US-4728469, 19880300, Danner et al.; US-4746716, 19880500, Oates; US-4842782, 19890600, Portney et al.; US-4851530, 19890700, Rickwood; US-4879318, 19891100, Lipscomb et al.; US-4889664, 19891200, Kindt-Larsen et al.; US-4902725, 19900200, Moore; US-4913544, 19900400, Rickwood et al.; US-4919850, 19900400, Blum et al.; US-4955804, 19900900, Martell et al.; US-4959429, 19900900, Misura et al.; US-4965294, 19901000, Ohngemach et al.; US-4968454, 19901100, Crano et al.; US-4983335, 19910100, Matsuo et al.; US-4988274, 19910100, Kenmochi; US-5028358, 19910700, Blum; US-5105126, 19920400, Girard, Jr.; US-5135686, 19920800, Masuhara et al.; US-5147585, 19920900, Blum; US-5154861, 19921000, McBrierty et al.; US-5238981, 19930800, Knowles; US-5274132, 19931200, Van Gemert; US-5364256, 19941100, Lipscomb et al.; US-5369158, 19941100, Knowles; US-5384077, 19950100, Knowles; US-5391327, 19950200, Ligas et al.; US-5405958, 19950400, Van Gemert; US-5411679, 19950500, Kumar; US-5415816, 19950500, Buazza et al.; US-5422046, 19950600, Tarshiani et al.; US-5429774, 19950700, Kumar; US-5451344, 19950900, Knowles et al.; US-5458814, 19951000, Kumar et al.; US-5458815, 19951000, Knowles; US-5464567, 19951100, Knowles et al.; US-5466398, 19951100, Van Gemert et al.; US-5470892, 19951100, Gupta et al., 264/001.38; US-5514214, 19960500, Joel et al.; US-5516468, 19960500, Lipscomb et al.; US-5529728, 19960600, Buazza et al.; US-5531940, 19960700, Gupta et al.; US-5621017, 19970400, Kobayakawa et al.; US-5681871, 19971000, Molock et al.; US-5689324, 19971100, Lossman et al.; US-5789015, 19980800, Gupta et al.; US-5851328, 19981200, Kohan; US-5880171, 19990300, Lim et al.; US-5910516, 19990600, Imura et al.; US-5928575, 19990700, Buazza; US-5976423, 19991100, Buazza; US-5989462, 19991100, Buazza et al.; US-6022498, 20000200, Buazza et al.
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