Non-absorbent substrates for the inhibition of exoprotein production from gram positive bacteria
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-007/16
A61K-009/06
출원번호
US-0724023
(2000-11-28)
발명자
/ 주소
Resheski-Wedepohl, Kim L.
Syverson, Rae Ellen
출원인 / 주소
Kimberly-Clark Worldwide, Inc.
대리인 / 주소
Senniger, Powers, Leavitt & Roedel
인용정보
피인용 횟수 :
5인용 특허 :
50
초록▼
Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B an
Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The substrates include an alkyl polyglycoside incorporated in or on at least a portion of the substrate. The alkyl polyglycoside typically has an HLB of about 10 to 15 and/or an average number of carbon atoms in the alkyl chain of about 8 to about 12.
대표청구항▼
Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B an
Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The substrates include an alkyl polyglycoside incorporated in or on at least a portion of the substrate. The alkyl polyglycoside typically has an HLB of about 10 to 15 and/or an average number of carbon atoms in the alkyl chain of about 8 to about 12. mplex of claim 1, wherein at least one of L, L', L1and L2is coupled to a polymeric backbone. 27. The complex of claim 26, wherein the polymeric backbone comprises at least one functional group that is a ligand of the complex. 28. The complex of claim 27, wherein the functional group is selected from a group consisting of pyridine and imidazole groups. 29. A transition metal complex having the formula: wherein c is a negative or positive charge represented by -1 to -5 or +1 to +5, inclusive, respectively; d is a number of counter ions, X, from 1 to 5, inclusive; X is chloride; M is cobalt, iron, osmium, ruthenium, or vanadium; L1is a substituted or an unsubstituted imidazole ligand; L2is a negatively charged ligand; and L and L' are independently: wherein R'1is a substituted or an unsubstituted alkyl, alkenyl, or aryl; Raand Rbare independently --H, --F, --Cl, --Br, --I, --NO2,--CN, --CO2H, --SO3H, --NHNH2,--SH, --OH, --NH2,or substituted or unsubstituted alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkoxy, alkylamino, dialkylamino, alkanoylamino, arylcarboxamido, hydrazino, alkylhydrazino, hydroxylamino, alkoxylamino, alkylthio, alkenyl, aryl, or alkyl; R'3,R'4are independently --H, --F, --Cl, --Br, --I, --NO2,--CN, --CO2H, --SO3H, --NHNH2,--SH, --OH, --NH2,or substituted or unsubstituted alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkoxy, alkylamino, dialkylamino, alkanoylamino, arylcarboxamido, hydrazino, alkylhydrazino, hydroxylamino, alkoxylamino, alkylthio, alkenyl, aryl, or alkyl, or a combination of R'3and R'4forms a saturated or an u
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