Topical plaster with non-steroidal antirheumatic agents with an acid group
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/02
A61F-013/00
A61L-015/16
A61K-009/70
출원번호
US-0743124
(2001-03-09)
우선권정보
DE-0030649 (1998-07-09)
국제출원번호
PCT/EP99/04686
(1999-07-06)
국제공개번호
WO00/02539
(2000-01-20)
발명자
/ 주소
Muller, Walter
출원인 / 주소
LTS Lohmann Therapie-Systeme
대리인 / 주소
Hochberg, D. PeterVieyra, Katherine R.Mellino, Sean
인용정보
피인용 횟수 :
21인용 특허 :
11
초록▼
A topical patch having non-steroid antirheumatic agent as active substance, consisting of a backing layer inert to the active substance, a self-adhesive, active substance-containing matrix layer based on a polyacrylate adhesive, and a protective film to be removed prior to use, is characterized in t
A topical patch having non-steroid antirheumatic agent as active substance, consisting of a backing layer inert to the active substance, a self-adhesive, active substance-containing matrix layer based on a polyacrylate adhesive, and a protective film to be removed prior to use, is characterized in that a. the non-steroid antirheumatic agent has a free carboxyl group, b. the active substance-containing matrix of the patch consists of a polyacrylate adhesive cross-linked with multivalent metal ions and having free carboxyl groups, and is free of hydroxyl groups, c. the matrix contains a fatty acid as plasticizer and permeation enhancer, and d. the backing layer consists of a material that is elastic in at least one direction.
대표청구항▼
1. Topical patch containing as active substance a non-steroid antirheumatic agent having a free carboxyl group, comprising: a backing layer inert to the active substance, which backing layer is made of a material that is elastic in at least one direction; a self-adhesive, active substance-contai
1. Topical patch containing as active substance a non-steroid antirheumatic agent having a free carboxyl group, comprising: a backing layer inert to the active substance, which backing layer is made of a material that is elastic in at least one direction; a self-adhesive, active substance-containing matrix layer consisting of a polyacrylate adhesive, which polyacrylate adhesive is crosslinked with multivalent metal ions and comprises free carboxyl groups, the said matrix containing a fatty acid; and a protective sheet to be removed prior to use, wherein said backing layer is made of at least one of an elastic polyester woven fabric or polyester knitted fabric, a nonwoven, a woven or a knitted fabric of polyethylene terephthalate, and a closed-cell, elastic foam, and said matrix comprises one layer and is free of hydroxyl groups. 2. Topical patch according to claim 1, wherein the non-steroid antirheumatic agent is a profen derivative. 3. Topical patch according to claim 1, wherein the active substance is selected from the group consisting of ketoprofen, ibuprofen, flurbiprofen and naproxen. 4. Topical patch according to claim 3, wherein the active substance is ketoprofen and is contained in the matrix of the patch in a concentration between 5 and 15%-wt. 5. Topical patch according to claim 4, wherein said active substance is contained in said matrix in a concentration between 6 and 10%-wt. 6. Topical patch according to claim 3, wherein the active substance is flurbiprofen and is contained in said matrix in a concentration between 5 and 15%-wt. 7. Topical patch according to claim 1, wherein the fatty acid is selected from the group consisting of oleic acid, linoleic acid and linolenic acid. 8. Topical patch according to claim 1, wherein the fatty acid is oleic acid and said fatty acid is present in said matrix in a concentration between 5 and 20%-wt. 9. Topical patch according to claim 1, wherein the polyacrylate adhesive has been produced by radical polymerization, said polymerization reaction including the polymerization of at least 2-ethylhexyl acrylate and acrylic acid. 10. Topical patch according to claim 1, wherein the polyacrylate adhesive has been produced by radical polymerization, said polymerization reaction including the polymerization of at least 2-ethylhexyl acrylate, vinyl acetate, acrylic acid, butyl acrylate. 11. Topical patch according to claim 1, wherein the backing layer consists of a polyethylene terephthalate woven fabric which is elastic in two directions. 12. Topical patch according to claim 1, wherein the closed-cell foam comprises at least one of polyethylene, polypropylene, polyvinyl chloride and a copolymer of ethylene and vinyl acetate. 13. Topical patch containing as active substance a non-steroid antirheumatic agent having a free carboxyl group, comprising: a backing layer inert to the active substance, which backing layer is made of a material that is elastic in at least one direction; a self-adhesive, active substance-containing matrix layer comprising a polyacrylate adhesive, which polyacrylate adhesive is crosslinked with multivalent metal ions and comprises free carboxyl groups, the said matrix containing a fatty acid; and a protective sheet to be removed prior to use, wherein said backing layer is made of at least one of an elastic polyester woven fabric or polyester knitted fabric, a nonwoven, a woven or a knitted fabric of polyethylene terephthalate, and a closed-cell, elastic foam, and said matrix comprises one layer and is free of hydroxyl groups.
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이 특허에 인용된 특허 (11)
Seymour Donald E. (Hertfordshire GB2), Adhesive-coated sheet material incorporating anti-bacterial substances.
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