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Parenteral bisphosphonate composition with improved local tolerance 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/66
출원번호 US-0758605 (2001-01-11)
우선권정보 EP-0101044 (2000-01-20)
발명자 / 주소
  • Diederich, Anke
  • Goldbach, Pierre
  • Pfister, Thomas
출원인 / 주소
  • Hoffmann-La Roches Inc.
대리인 / 주소
    Johnston, George W.Rocha-Tramaloni, Patricia S.Lau, Bernard
인용정보 피인용 횟수 : 31  인용 특허 : 25

초록 ▼

The present invention relates to a parenteral composition comprising a bisphosphonic acid or a pharmaceutically acceptable salt thereof (bisphosphonate) as active component and a pharmaceutically acceptable chelating agent, processes of the preparation of this composition, and methods of their use i

대표청구항 ▼

1. A method for the treatment and prevention of diseases involving bone resorption, osteoporosis, Paget's disease, hypercalcemia of malignancy, and metabolic bone disease comprising the step of administering to a patient in need of such treatment and prevention a parenteral composition having a pH o

이 특허에 인용된 특허 (25)

  1. Isomura Yasuo (Tokyo JPX) Takeuchi Makoto (Tokyo JPX) Sakamoto Shuichi (Tokyo JPX) Abe Tetsushi (Saitama JPX), (Cycloalkylamino)methylenebis(phosphonic acid).
    상세보기
  2. Blum Helmut (Dusseldorf DT) Worms Karl-Heinz (Dusseldorf DT), 1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids and salts.
    상세보기
  3. Gall Rudi (Mannheim DEX) Bosies Elmar (Mannheim DEX), 1-hydroxy-3-(N-methyl-N-propylamino)propane-1,1-diphosphonic acid, pharmaceutical compositions and methods of use.
    상세보기
  4. Blum Helmut (Duesseldorf DEX) Hemmann Siglinde (Meerbusch DEX), 4-dimethylamino-1-hydroxybutane-1,1-diphosphonic acid, salts thereof, and processes therefor.
    상세보기
  5. Breliere Jean C. (Montpellier FRX) Emonds-Alt Xavier (Montpellier FRX) Garcia Georges (Saint-Gely-du-Fesc FRX), Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation.
    상세보기
  6. Breliere Jean C. (Montpellier FRX) Emonds-Alt Xvier (Montpellier FRX) Garcia Georges (Saint-Gely-du-Fesc FRX), Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation.
    상세보기
  7. Daifotis Anastasia G. (Westfield NJ) Yates Ashley J. (Westfield NJ), Bisphosphonates prevent bone loss associated with immunosuppressive therapy.
    상세보기
  8. Blackwell ; III Joseph T. (Greensboro NC) Grace Henry C. (Baton Rouge LA) Nabors James B. (Baton Rouge LA) Petree Harris E. (Kernersville NC), Chemical process for the preparation of 2,6-dialkylcyclohexylamines from 2,6-dialkylphenols.
    상세보기
  9. Gall Rudi (Hirschberg DEX) Bosies Elmar (Weinheim DEX), Diphosphonate derivatives, pharmaceutical compositions and methods of use.
    상세보기
  10. Bosies Elmar (Weinheim DEX) Gall Rudi (Hirschberg DEX), Diphosphonate derivatives, pharmaceutical compositions and methods of use for calcium disturbances.
    상세보기
  11. Bosies Elmar (Weinheim DEX) Zilch Harald (Mannheim DEX), Diphosphonic acid compounds and use for calcium metabolism disorders.
    상세보기
  12. Bosies Elmar (Weinheim DEX) Gall Rudi (Hirschberg DEX), Diphosphonic acid derivatives.
    상세보기
  13. Bosies Elmar (Weinheim DEX) Gall Rudi (Hirschberg DEX), Diphosphonic acid derivatives, pharmaceutical compositions and methods.
    상세보기
  14. Bosies Elmar (Weinheim DEX) Gall Rudi (Hirschberg DEX), Diphosphonic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them.
    상세보기
  15. Blum Helmut (Dsseldorf DEX) Hempel Hans-Ulrich (Overath DEX) Worms Karl-Heinz (Dsseldorf DEX), Hydroxyalkane diphosphonic acids.
    상세보기
  16. Sage ; Jr. Burton H. ; Green Philip G., Method for the iontophoretic administration of bisphosphonates.
    상세보기
  17. Gordon Larry E. (Chelmsford MA), Method of laser marking metal packages.
    상세보기
  18. Schmidt-Dunker Manfred (Dusseldorf DT), Method of treatment of calcium disorders using aminoalkane-diophosphonic acids.
    상세보기
  19. Rosini Sergio (Pisa ITX) Staibano Giorgio (Pisa ITX), Pharmacologically active biphosphonates, process for the preparation thereof and pharmaceutical compositions therefrom.
    상세보기
  20. Cirelli Giorgio (Nussbaumen CHX) Steffen Hans (Liestal CA CHX) Surber Christian (San Francisco CA), Portable injection appliance.
    상세보기
  21. Kieczykowski Gerard R. (Westfield NJ), Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof.
    상세보기
  22. Blum Helmut (Dusseldorf DEX) Worms Karl-Heinz (Dusseldorf DEX), Process for the production of 3-amino-1-hydroxypropane-1,1-diphosphonic acid.
    상세보기
  23. Blum Helmut (Dusseldorf DEX) Worms Karl-Heinz (Dusseldorf DEX), Process for the production of w 상세보기
  • Flora Lawrence (Fairfield OH) Floyd Benjamin F. (Cincinnati OH), Regimen for treating osteoporosis.
    상세보기
  • Bosies Elmar (Weinheim DEX) Gall Rudi (Hirschberg DEX), Triazole containing diphosphonate compounds and the use thereof.
    상세보기

    • 이 특허를 인용한 특허 (31)

    1. Hanna, Mazen; Shan, Ning; Cheney, Miranda L.; Weyna, David R.; Isbester, Paul K.; Sun, Xufeng, Crystalline forms.
      상세보기
    2. Hanna, Mazen, Crystallization method and bioavailability.
      상세보기
    3. Hanna, Mazen; Shan, Ning; Cheney, Miranda L.; Weyna, David R.; Houck, Raymond, Crystallization method and bioavailability.
      상세보기
    4. Hanna, Mazen; Shan, Ning; Cheney, Miranda L.; Weyna, David R.; Houck, Raymond, Crystallization method and bioavailability.
      상세보기
    5. Hanna, Mazen; Shan, Ning; Cheney, Miranda L.; Weyna, David R.; Houck, Raymond K., Crystallization method and bioavailability.
      상세보기
    6. Hanna, Mazen; Shan, Ning; Cheney, Miranda L.; Weyna, David R.; Houck, Raymond K., Crystallization method and bioavailability.
      상세보기
    7. Hanna, Mazen; Shan, Ning; Cheney, Miranda; Weyna, David; Houck, Raymond K., Crystallization method and bioavailability.
      상세보기
    8. Dansereau, Richard John; Burgio, Jr., David Ernest, Dosage forms of bisphosphonates.
      상세보기
    9. Dansereau, Richard John; Burgio, Jr., David Ernest, Dosage forms of bisphosphonates.
      상세보기
    10. Dansereau, Richard John; Burgio, Jr., David Ernest, Dosage forms of bisphosphonates.
      상세보기
    11. Dansereau, Richard John; Burgio, Jr., David Ernest, Dosage forms of risedronate.
      상세보기
    12. DiPerna, Paul M, Flow regulating stopcocks and related methods.
      상세보기
    13. McManus, Samuel P.; Kozlowski, Antoni, Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom.
      상세보기
    14. McManus, Samuel P.; Kozlowski, Antoni, Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom.
      상세보기
    15. Bobyn, John Dennis; Tanzer, Michael, Implant improving local bone formation.
      상세보기
    16. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
      상세보기
    17. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
      상세보기
    18. Michaud, Michael; Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
      상세보기
    19. Michaud, Michael; Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
      상세보기
    20. Verhoef, Erik T.; DiPerna, Paul M.; Rosinko, Mike; Williamson, Mark; Kruse, Geoffrey A.; Ulrich, Thomas R.; Lamb, Phil; Saint, Sean; Michaud, Michael; Trevaskis, William, Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
      상세보기
    21. Zhang, Jack Yongfeng; Luo, Mary Ziping; Fei, Dingyuan; Xie, Kevin; Ding, Jie Fei, Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate.
      상세보기
    22. Dansereau, Richard John; Burgio, Jr., David Ernest, Low dosage forms of risedronate or its salts.
      상세보기
    23. Dansereau, Richard John; Burgio, Jr., David Ernest, Low dosage forms of risedronate or its salts.
      상세보기
    24. Liu, Gang; Men, Ping, Methods for chelation therapy.
      상세보기
    25. Liversidge, Gary G.; Jenkins, Scott, Nanoparticulate bisphosphonate compositions.
      상세보기
    26. DiPerna, Paul M., Slideable flow metering devices and related methods.
      상세보기
    27. Brown, David, Solute concentration measurement device and related methods.
      상세보기
    28. Rosinko, Michael J.; Kruse, Geoffrey A.; Harris, Paul, System and method for detecting occlusions in an infusion pump.
      상세보기
    29. Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Systems including vial adapter for fluid transfer.
      상세보기
    30. DiPerna, Paul M., Two chamber pumps and related methods.
      상세보기
    31. von Andrian, Ulrich H.; Iannacone, Matteo; Tonti, Elena; Moseman, Elliott Ashley, Vaccines comprising bisphosphonate and methods of use thereof.
      상세보기

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