[특허]Method of inducing and maintaining neuronal cells

[미국특허] Method of inducing and maintaining neuronal cells 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-005/00
출원번호	US-0835279 (1997-04-09)
발명자 / 주소	Melton, Douglas A. Hemmati-Brivanlou, Ali
출원인 / 주소	President and Fellows of Harvard College
대리인 / 주소	Ropes & Gray LLP
인용정보	피인용 횟수 : 59 인용 특허 : 3

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The present invention makes available a method for inducing neuronal differentiation and preventing the death or degeneration of neuronal cells both in vitro and in vivo. The subject method stems from the unexpected finding that, contrary to traditional understanding of neural induction, the default fate of ectodermal tissue is neuronal rather than mesodermal and/or epidermal. In particular, it has been discovered that preventing or antagonizing a signaling pathway in a cell for a growth factor of the TGF-β family can result in neuronal differentiation of that cell. homocysteine-converting enzyme, a homocysteine cosubstrate, and a D-amino acid converting enzyme. 13. The kit of claim 12, further comprising NAD(P)H, dehydrogenase using NAD(P)H as a coenzyme, and an ammonium salt or 2-oxo acid as its cosubstrate. 14. The kit of claim 9, wherein the homocysteine-converting enzyme is a methyltransferase using homocysteine as a methyl acceptor, and the homocysteine cosubstrate is a methyl donor. 15. The kit of claim 14, wherein the methyltransferase is homocysteine methyltransferase, and the methyl donor is D-methionine methyl sulfonium. 16. The kit of claim 12, wherein the D-amino acid converting enzyme is D-amino acid oxidase. 17. The method of claim 5, wherein the D-amino acid converting enzyme is D-amino acid oxidase. 18. The method of claim 5, wherein in the step (c), the produced hydrogen peroxide is detected or determined by color development using peroxidase and an oxidative color-developing agent. 19. The method of claim 6, wherein in the step (c), the produced hydrogen peroxide is detected or determined by color development using peroxidase and an oxidative color-developing agent. 20. The method of claim 5, wherein in the step (c), a decrease in NAD(P)H or an increase in NAD(P) is detected or determined by reacting the produced oxo acid and/or ammonia with dehydrogenase using NAD(P)H as a coenzyme. 21. The method of claim 6, wherein in the step (c), a decrease in NAD(P)H or an increase in NAD(P) is detected or determined by reacting the produced oxo acid and/or ammonia with dehydrogenase using NAD(P)H as a coenzyme. 22. The kit of claim 12, wherein the homocysteine-converting enzyme is a methyltransferase using homocysteine as a methyl acceptor, and the homocysteine cosubstrate is a methyl donor. 23. The kit of claim 13, wherein the homocysteine-converting enzyme is a methyltransferase using homocysteine as a methyl acceptor, and the homocysteine cosubstrate is a methyl donor. 24. The kit of claim 13, wherein the D-amino acid converting enzyme is D-amino acid oxidase. 25. The kit of claim 14, wherein the D-amino acid converting enzyme is D-amino acid oxidase. 26. The kit of claim 15, wherein the D-amino acid converting enzyme is D-amino acid oxidase.

이 특허에 인용된 특허 (3) 인용/피인용 타임라인 분석

Ling Nicholas C. K. (San Diego CA) Ueno Naoto (Ibaraki CA JPX) Shimasaki Shunichi (San Diego CA) Esch Frederick S. (Forest City CA) Ying Shao-Yao (San Diego CA) Guillemin Roger C. L. (La Jolla CA), Mammalian follistatin.
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Ling Nicholas C. K. (San Diego CA) Ueno Naoto (Ibaraki CA JPX) Shimasaki Shunichi (San Diego CA) Esch Frederick S. (Foster City CA) Ying Shao-Yao (San Diego CA) Guillemin Roger C. L. (La Jolla CA), DNA encoding follistatin.
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Williams Robert L. (Warrndyte AUX) Gough Nicholas M. (North Balwyn AUX) Hilton Douglas J. (Warrandyte AUX), In vitro propagation of embryonic stem cells.
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[미국특허] Method of inducing and maintaining neuronal cells 원문보기

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