Process of obtaining compositions of stable lutein and lutein derivatives
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/78
A61K-009/00
A61K-047/00
B01J-041/00
출원번호
US-0058827
(2002-01-30)
발명자
/ 주소
Majeed, Muhammed
출원인 / 주소
Sabinsa Corporation
대리인 / 주소
Arent Fox Kintner Plotkin & Kahn, PLLC
인용정보
피인용 횟수 :
10인용 특허 :
7
초록
The present invention concerns methods of obtaining stable lutein and its derivatives. Additionally, the invention concerns various compositions comprising lutein, lutein esters, tetrahydrocurcuminoids, and carnosic acid.
대표청구항▼
The present invention concerns methods of obtaining stable lutein and its derivatives. Additionally, the invention concerns various compositions comprising lutein, lutein esters, tetrahydrocurcuminoids, and carnosic acid. is," Cancer and Metastasis, 17:25-37, 1998. Frank and Pahl, "Nutraceuticals-F
The present invention concerns methods of obtaining stable lutein and its derivatives. Additionally, the invention concerns various compositions comprising lutein, lutein esters, tetrahydrocurcuminoids, and carnosic acid. is," Cancer and Metastasis, 17:25-37, 1998. Frank and Pahl, "Nutraceuticals-Food, dietary supplement or drug?," Biotech. Law Report, 18(2):131-143, 1999. Frechet et al., "Four triterpenoid saponins from dried roots of Gypsophila species," Phytochemistry, 30:927-931, 1991. Fulda, et al., "Betulinic Acid Triggers CD95 (APO-1/Fas)- and p53-independent Apoptosis via Activation of Caspases in Neuroectodermal Tumors," Cancer Research, 57:4946-4964, 1997. Gariboldi et al., "Saponins from Crossopteryx febrifuga," Phytochemistry, 29(8):2629-2635, 1990. Green and Reed, Mitochondria and Apoptosis,: Science, 281:1309-1312. Hamburger et al., "Acetylated saponins with molluscicidal activity from Sapindus rarak: unambiguous structure determination by proton nuclear magnetic resonance and quantitative analysis," Phytochem. Anal., 3:231-237, 1992. Harmon et al., "Activation of mammalian retinoid X receptors by the insect growth regulator methoprene," Proc. Natl. Acad. Sci. USA, 92:6157-6160, 1995. Harris et al., "Inhibiting cholesterol absorption with CP-88,818 (β-Tigogenin cellobioside; tiqueside): studies in normal and hyperlipidemic subjects," J. Cardiovascular Pharmacology, 30:55-60, 1997. Harwood et al., Phamacologic consequences of cholesterol absorption inhibition: alteration in cholesterol metabolism and reduction in plasma cholesterol concentration induced by the synthetic saponin β-tigogenin cellobioside (CP-88,818; tiqueside), J. Lipid. Res. 34:377-395, 1993. Hassanain et al., "Enhanced gel mobility shift assay for DNA-binding factors," Anal. Biochem., 213:162-167, 1993. Honda et al., "New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages," Bioorganic Med. Chem. Ltrs, 7(13):1623-1628, 1997. Hu and Alfermann, "Diterpenoid production in hairy root cultures of Salvia miltiorrhiza," Phytochemistry, 32(3):699-703; 1993. Huang et al., "Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid," Cancer Research, 54:701-708, 1994. Ikeda et al., "Cytotoxic glycosides form Albizzia julibrissin," J. Nat. Prod., 60(2):102-107, 1997. International Search Report dated Sep. 21, 1999. Jiang et al., "Triterpenoid glycosides from the bark of Mimosa tenuiflora," Phytochemistry, 30(7):2357-2360, 1991. Jung et al., "Improvement of the catharanthine productivity in hairy root cultures of Catharanthus roseus by using monosaccharides as a carbon source," Biotech. Lett., 14(8):695-700; 1992. Kamel et al., "Studies on Balanites aegyptiaca fruits, an antidiabetic Egyptian folk medicine," Chem. Pharm. Bull., 39(5):1229-1233, 1991. Kennedy et al., "The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal," Genes and Dev., 11:701-713, 1997. Kojima and Ogura, "Configurational studies on hydroxy groups at C-2, 3 and 23 or 24 of oleanene and ursene-type triterpenes by NMR spectroscopy," Phytochemistry, 28:1703-1710, 1989. Lister et al., Acacia in Australia: Ethnobotany and potential food crop. p. 228-236. In: J. Janick (ed.), Progress in new crops. ASHS Press, Alexandria, VA, 1996. Lyss et al., "The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65," J. Biol. Chem, 273(50):33508-33516, 1998. Ma et al., "NMR determination of the structure of Julibroside J1," Carbohydr. Res., 281(1):35-46, 1996. Mangelsdorf et al., "The nuclear receptor superfamily: The second decade," Cell, 83:835-839, 1995. Mannick et al., "Fas-induced caspase denitrosylation," Science, 284:651-654, 1999. Martin et al., "Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl," J. Exp. Med., 182:1545-1556, 1995. Massiot et al., "Saponins from aerial parts of alfalfa (Medicago sativa)," J. Agric. Food Chem., 39:78-82, 1991b. Massiot et al., "Saponins from Tridesmostemon cl aessenssi," Phytochemistry, 29:3291-3298, 1990. Massiot et al., "Structural elucidation of alfalfa root saponins by mass spectrometry and nuclear magnetic resonance analysis," J. Chem. Soc., Perkin Trans., 1:3071-3079, 1988. McManus et al., "An activator of calcium-dependant potassium channels isolated from a medicinal herb," Biochem., 32:6128-6133, 1993. Miller and Marx, "Apoptosis," Science, 281:1301-1302, 1998. Moore, "Diversity and unity in the nuclear hormone receptors: a terpenoid receptor superfamily," The New Biologist, 2(1):100-105, 1990. Mujoo et al., "Adenoviral-mediated p53 tumor supressor gene therapy of human ovarian carcinoma," Oncogene, 12:1617-1623, 1996. Nagao et al., "Studies on the constituents of Aster tataricus L. f. II. Structures of aster saponins isolated from the root," Chem. Pharm. Bull., 37(8):1977-1983, 1989. Nelson et al., "Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors," Proc. Natl. Acad. Sci. USA, 89(14):6398-6402, 1992. Nishino et al., "The structure of the tetrasaccharide unit of camellidins, saponins, possessing antifungal activity," J. Chem. Soc., Chem. Commun., 720-723, 1986. Norman, "Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs," J. Med. Chem., 39:1106-1111, 1996. Ohkawa et al., "Effects of gibberellic acid on hairy root growth in Datura innoxia," J. Plant Physiol., 134:633-636; 1989. Okabe et al., "Studies on the constituents of Luffa operculata COGN. II. Isolation and structure elucidation of saponins in the herb," Chem. Pharm. Bull., 37(4):895-900, 1989. Okada et al., "Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase,"J. Bio. Chem., 269:3563-3567, 1994. Potterat et al., Saponins with an unusual secoursene skeleton from Sesamum alatum THONN1., Helv. Chim. Acta, 75:833-841, 1992. Prehn, "Regeneration versus neoplastic growth," Carcinogenesis, 18(8):1439-1444, 1997. Puri et al., "Solasodine and diosgenin: 1H and 13C assignments by two-dimensional NMR spectroscopy," Mag. Res. Chem., 31:278-282, 1993. Rhodes, et al., "Influence of exogenous hormones on the growth and secondary metabolite formation in transformed root cultures," Plant Cell Tissue Organ Culture, 38:143-151; 1994. Rodriguez et al., "Holothurinosides: new anti-tumour non sulphated triterpenoid glycosides from the sea cucumber Holothruia forskalii," Tetrahedron, 47:4753-4762, 1991. Royal and Park, "Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase," J. Biol. Chem. 270(46):27780-27787, 1995. Schopke et al., "Bellissaponins BA1and BA2,acylated saponins from Bellis perennis," Phytochemistry, 30:627-631, 1991. Schreiber et al., "Rapid detection of octamer binding proteins with `mini-extracts`, prepared from a smaller number of cells," Nucleic Acids Res., 17(15):6419, 1989. Schuh et al., "Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice," Nature, 346:756-760, 1990. Shao et al., "Saponins from roots of Kalopanax septemlobus. (Thunb.) Koidz., Ciqiu: structures of kalopanaxsaponins C, D, E and F," Chem. Pharm. Bull., 37(2):311-314, 1989. Shirazi et al., "Exposure to ultraviolet B radiation increases the tolerance of mouse skin to daily X-radiation," Rad. Res., 145:768-775, 1996. Sieweke et al., "Mediation of wound-related rous sarcoma virus tumorigenesis by TGF-β," Science, 248:1656-1660, 1990. Smith et al., "Effects of gibberellic acid on hairy root cultures of Artemisia annua: growth and artemisinin production," In Vitro Cell Dev. Biol., 33:75-79, 1997. Spady et al., "Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids" Annu. Rev. Nutr., 13:355-381, 1993. Tabas et al., "Rabbit and human liver contain a novel
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