초록 ▼

Novel emulsion compositions which improve the rate and/or extent of absorption of drugs are disclosed. The novel emulsion compositions of the present invention include drug-containing emulsions adsorbed onto solid particles which may be further formulated into solid dosage forms, methods of preparin

Novel emulsion compositions which improve the rate and/or extent of absorption of drugs are disclosed. The novel emulsion compositions of the present invention include drug-containing emulsions adsorbed onto solid particles which may be further formulated into solid dosage forms, methods of preparing such emulsion compositions and their uses thereof. The emulsion compositions and their dosage forms improve the drug-load and the bioavailability of a wide range of drugs including drugs that are known or suspected of having poor bioavailability by the utilization of several different mechanisms.

대표청구항 ▼

Novel emulsion compositions which improve the rate and/or extent of absorption of drugs are disclosed. The novel emulsion compositions of the present invention include drug-containing emulsions adsorbed onto solid particles which may be further formulated into solid dosage forms, methods of preparin

Novel emulsion compositions which improve the rate and/or extent of absorption of drugs are disclosed. The novel emulsion compositions of the present invention include drug-containing emulsions adsorbed onto solid particles which may be further formulated into solid dosage forms, methods of preparing such emulsion compositions and their uses thereof. The emulsion compositions and their dosage forms improve the drug-load and the bioavailability of a wide range of drugs including drugs that are known or suspected of having poor bioavailability by the utilization of several different mechanisms. hem. and Biophys. Res. Comm., 65(1):399-406 (1975). Morishita, M., et al., "Novel Oral Microspheres of Insulin With Protease Inhibitor Protecting from Enzymatic Degradation," Intl. J. Pharmaceutics, 78:1-7 (1992). Kidron, M., et al., "The Absorption of Insulin From Various Regions of the Rat Intestine," Life Science, 31(25):2837-2841 (1982). Kraeling, M.E.K. and Ritschel, W.A., "Development of a Colonic Release Capsule Dosage Form and the Absorption of Insulin," Meth. Find Exp. Clin. Pharmacol., 14(3):199-209 (1992). Lee, V.H.L., et al., "Oral Route of Peptide and Protein Drug Delivery," V.H.L. Lee (Ed.): Peptide and Protein Drug Delivery, Marcel Dkkr, 1991 New York, pp 691-738. Morishita, M., et al., "Novel Oral Microspheres of Insulin With Protease Inhibitor Protecting From Enzymatic Degradation," Intl. J. Pharmaceutics, 78:1-7 (1992). Muranishi, S., "Absorption Enhancers," Critical Reviews in Therapeutic Drug Carrier Systems, 7(1):1-34 (1990). Osborne, R., et al., "Morphine and Metabolite Behavior After Different Routes of Morphine Administration: Demonstration of the Importance of the Active Metabolite Morphine-6-Glucuronide," Clin. Pharmacol. Ther., 47(1):12-19 (1990). Schulte-Hermann, R. and Parzefall, W., "Adaptive Responses of Rat Liver to the Gestagen and Anti-Androgen Cyproterone Acetate and Other Inducers. I. Induction of Drug-Metabolizing Enzymes," Chem. Biol. Interactions, 31:279-286 (1980). Patel, H.M. and Ryman, B.E., "Oral Administration of Insulin by Encapsulation Within Liposomes," FEBS Letters, 26(1):60-63 (1976). Peters, W.H.M., et al., "Glutathione S-Transferase, Cytochrome P450, and Uridine 5'-Diphosphate-Glucuronosyltransferase in Human Small Intestine and Liver," Gastroenterology, 96:783-789 (1989). Saffran, M., et al., "A New Approach to the Oral Administration of Insulin and Other Peptide Drugs," Science, 233:1081-1084 (1986). Sanders, L.M., et al., "Prolonged Controlled-Release of Nafarelin, A Luteinizing Hormone-Releasing Hormone Analogue, From Biodegradable Polymeric Implants: Influence of Compos