The invention is a beverage device having a beverage pack, such as a bag containing substances to be added to flavor a liquid and a shield. The shield is connected to the pack and encapsulates the pack in the bottom of a cup. The shield has an open orientation which allows beverage pack steeping and
The invention is a beverage device having a beverage pack, such as a bag containing substances to be added to flavor a liquid and a shield. The shield is connected to the pack and encapsulates the pack in the bottom of a cup. The shield has an open orientation which allows beverage pack steeping and a closed orientation. The shield can be made from two portions. A stick can be used to push the shield to the bottom of the cup and orient the shield in its closed orientation.
대표청구항▼
The invention is a beverage device having a beverage pack, such as a bag containing substances to be added to flavor a liquid and a shield. The shield is connected to the pack and encapsulates the pack in the bottom of a cup. The shield has an open orientation which allows beverage pack steeping and
The invention is a beverage device having a beverage pack, such as a bag containing substances to be added to flavor a liquid and a shield. The shield is connected to the pack and encapsulates the pack in the bottom of a cup. The shield has an open orientation which allows beverage pack steeping and a closed orientation. The shield can be made from two portions. A stick can be used to push the shield to the bottom of the cup and orient the shield in its closed orientation. tment, comprising: a polymer-platinum complex designed to accumulate at a tumor site and composed of an N-alkyl acrylamide copolymer of the form: where m=0 and n=100 or where the ratio of m:n is 0.1-99.9, where R1is CH3,R2is 2-hydroxypropyl, and R3is Gly-Phe-Leu-Gly-Ama or Gly-Gly-Ama having side chains spaced along the polymer for complexing with a platinum compound, said side chains (i) composed of an oligopeptide attached at one end to the polymer and at the other end, at least primarily via a N,O-amidomalonate complex, to the platinum compound and (ii) comprising at least one linkage designed to be cleaved under selected physiological conditions to yield a platinum compound which has, or is converted in vivo to have, anti-tumor activity. 4. A method of treating solid tumor in a subject with a platinum compound, the method comprising preparing a polymer-platinum complex composed of an N-alkyl acrylamide polymer having side chains spaced along the polymer for complexing with a platinum compound, said side chains (i) composed of an Gly-(W)p-Gly where p is 0-3 and W is an amino acid or combination of any amino acids attached at one end to the polymer and at the other end to the platinum compound via a N, O-amidomalonate complex and (ii) comprising at least one linkage designed to be cleaved under selected physiological conditions to yield the platinum compound which has, or is converted in vivo to have, anti-tumor activity; and parenterally administering a pharmaceutically effective amount of the complex to the subject. 5. A method of treating a solid tumor in a subject with a platinum compound, the method comprising preparing a polymer-platinum complex composed of an N-alkyl acrylamide polymer having side chains spaced along the polymer for complexing with a platinum compound, said side chains (i) composed of Gly-Phe-Leu-Gly or Gly-Gly oligopeptide attached at one end to the polymer and at the other end to the platinum compound via a N, O-amidomalonate complex and (ii) comprising at least one linkage designed to be cleaved under selected physiological conditions to yield the platinum compound which has, or is converted in vivo to have, anti-tumor activity; and parenterally administering a pharmaceutically effective amount of the complex to the subject. 6. A method of treating a solid tumor in a subject with a platinum compound, the method comprising preparing a polymer-platinum complex compound of an N-alkyl acrylamide polymer having side chains spaced along the polymer for complexing with a platinum compound, said side chains (i) composed of an oligopeptide attached at one end to the polymer and at the other end to the platinum compound via a N, O-amidomalonate complex and (ii) comprising at least one linkage designed to be cleaved under selected physiological conditions to yield the platinum compound which has, or is converted in vivo to have, anti-tumor activity; and parenterally administering a pharmaceutically effective amount of the complex to the subject, wherein said oligopeptide is Gly-(W)P-Gly where p is 0-3 and W is an amino acid or combination of any amino acids. 7. A method of treating a solid tumor in a subject with a platinum compound, the method comprising preparing a polymer-platinum complex compound of an N-alkyl acrylamide polymer having side chains spaced along the polymer for complexing with a platinum compound, said side chains (i) composed of an oligopeptide attached at one end to the polymer and at the other end to the platinum compound via a N, O-amidomalonate complex and (ii) comprising at least one linkage designed to be cleaved under selected physiological conditions to yield the platinum compound which has, or is converted in vivo to have, anti-tumor activity; and parenterally administering a pharmaceutically effective amount of the complex to the subject, wherein said oligopeptide is Gly-Phe-Leu-Gly or Gly-Gly.
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