[특허]Shear-sensitive injectable delivery system

[미국특허] Shear-sensitive injectable delivery system 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-037/00
출원번호	US-0487436 (2000-01-19)
발명자 / 주소	Gellman, Barry N.
출원인 / 주소	SciMed Life Systems, Inc.
대리인 / 주소	Testa, Hurwitz & Thibeault, LLP
인용정보	피인용 횟수 : 58 인용 특허 : 32

초록 ▼

A delivery system for delivering a shear-sensitive injectable material into the body of a mammal, such as a human being, acts as a mechanical feed that continuously mixes a shear-sensitive injectable material as it delivers the shear-sensitive injectable material to a target tissue, or to a site adjacent a target tissue. In one embodiment of the invention, the delivery system comprises an injector system including a rotatable mixing member coupled to a driving system. The injector system comprises a housing defining a lumen and having an output end and a driving system connection end and includes a rotatable mixing member for coupling to the driving system and for mixing and delivering the shear-sensitive injectable material. The driving system comprises a drive mechanism, an actuator capable of actuating the drive mechanism, and an interfacing member coupled to the drive mechanism for coupling with the mixing member to rotate the mixing member when the interfacing member is driven by the drive mechanism.

대표청구항 ▼

1. An injector system, comprising: a housing defining a lumen and having an output end and a driving system connection end, the lumen comprising a proximal portion and a distal portion and the inner diameter of the proximal portion being substantially larger than the inner diameter of the distal portion; a mixing member extending within the lumen from the driving system connection end to at least the output end, the mixing member being rotatable within the lumen in both the proximal portion and the distal portion; and a needle assembly coupled to the output end of the housing, for coupling to a needle. 2. The injector system of claim 1, wherein the mixing member comprises a helical element. 3. The injector system of claim 2, wherein the helical element is an auger. 4. The injector system of claim 1, further comprising a driver guide, the driver guide positioning the mixing member within the lumen. 5. The injector system of claim 1, wherein the needle assembly is coupled to a needle. 6. The injector system of claim 1, further comprising an injectable material. 7. The injector system of claim 6, wherein the injectable comprises a shear-sensitive injectable material. 8. The injector system of claim 7, wherein the shear-sensitive injectable material comprises a cross-linked material, a carrier, and a matrix material. 9. The injector system of claim 7, wherein the injectable material further comprises a bioactive molecule. 10. The injector system of claim 7, wherein the housing comprises a feeder portion and a reservoir portion, and wherein the mixing member is rotatable within the feeder portion and can move linearly within the reservoir portion. 11. The injector system of claim 1, wherein the lumen further comprises a middle portion having an inner diameter substantially larger than the inner diameter of the proximal portion. 12. The injector system of claim 1 wherein the mixing member comprises a screw having a proximal end and a distal end, the screw being-extendable and rotatable within both the proximal portion and the distal portion of the lumen, the injector system further comprising a drive mechanism coupled to the proximal end of the screw, to rotate the screw when the drive mechanism is actuated. 13. The injector system of claim 12, further comprising an actuator, the actuator coupled to the drive mechanism to actuate the drive mechanism. 14. The injector system of claim 12, wherein an outer diameter of the screw decreases from the proximal end to the distal end. 15. The injector system of claim 12, wherein a pitch of the screw increases from the proximal end to the distal end. 16. The injector system of claim 12, wherein a radial thread height of the screw increases from the proximal end to the distal end.

이 특허에 인용된 특허 (32) 인용/피인용 타임라인 분석

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Neer Charles (Milford OH) Fago Frank M. (Mason OH) Dieterlen Paul E. (Covington KY) Goethel James H. (Cincinnati OH), Disposable front loadable syringe.
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Wallace Donald G. (Menlo Park CA) Reihanian Hertsel (San Francisco CA) Pharriss Bruce B. (Palo Alto CA) Braun William G. (Los Altos CA), Injectable implant composition having improved intrudability.
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Kruder George A. (Marion OH), Injection molding machine with multichannel wave screw.
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Barker Donald ; Seaton James P., Integrated bone cement mixing and dispensing system.
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Jones Shedrick D. (4330 Olympiad Dr. Los Angeles CA 90043), Method and apparatus for implantation.
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Pokras Norman M. (4448 Village Rd. Long Beach CA 90808), Method and apparatus for vibrating an injection device.
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Choksi Pradip V. (Northridge CA) Michael Kenneth R. (Canoga Park CA) Penny William H. (Arcadia CA), Method of mixing plural components.
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Miller Kenneth L. (Indianapolis IN), Motionless mixer tube for resin dispensing equipment.
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Baum Thomas M. (Raleigh NC), Multi-pressure injector device.
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Haber Terry M. (Lake Forest CA) Smedley William H. (Lake Elsinore CA) Foster Clark B. (Laguna Niguel CA), Pharmaceutical storage and mixing syringe having high pressure assisted discharge.
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Hendrickson Carl E. (P.O. Box 81 Sheridan WY 82801), Portable device for mixing two materials.
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Armbruster Randy E. (Rochester NY) Semmler Bruce J. (Spencer Port NY), Portable hand-held power injector.
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Graham, Neil B., Preparation of particulate gels.
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Wacks Jonathan L. (Forest Hills NY), Safety syringe for mixing two-component medicaments.
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Lau Anderson,TWX, Screw conveyor-type delivery and mixing device for plastics injecting molding machine.
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Summers David P. (Montgomery TX), Spinal disc surgical instrument.
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Laptewicz ; Jr. Joseph E. (Stonington CT), Surgical adhesives mixing and dispensing implement.
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Cole Susan M. (Minneapolis MN) Garbe James E. (Inver Grove Heights MN) Woodson Lewis P. (Eagan MN), Water-insoluble polysaccharide hydrogel foam for medical applications.
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[미국특허] Shear-sensitive injectable delivery system 원문보기

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