IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0300079
(2002-11-20)
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발명자
/ 주소 |
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| 출원인 / 주소 |
|
| 대리인 / 주소 |
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| 인용정보 |
피인용 횟수 :
42 인용 특허 :
11 |
초록
▼
The present invention is directed toward cyanoacrylate-based tissue adhesive or sealant compositions comprising cyanoacrylate-capped heterochain polymers, such as those comprising one or more oxyalkylene, alkylene carbonate, and ester-units derived from cyclic lactones. Such compositions can be radi
The present invention is directed toward cyanoacrylate-based tissue adhesive or sealant compositions comprising cyanoacrylate-capped heterochain polymers, such as those comprising one or more oxyalkylene, alkylene carbonate, and ester-units derived from cyclic lactones. Such compositions can be radiochemically sterilized and used in repairing internal organs or tissue blocking body conduits.
대표청구항
▼
1. A curable, liquid, cyanoacrylate-based composition comprising a cyanoacrylate-capped heterochain polymer having at least two cyanoacrylate ester groups per chain. 2. A curable, liquid, cyanoacrylate-based composition as in claim 1 wherein the heterochain polymer is selected from the group consist
1. A curable, liquid, cyanoacrylate-based composition comprising a cyanoacrylate-capped heterochain polymer having at least two cyanoacrylate ester groups per chain. 2. A curable, liquid, cyanoacrylate-based composition as in claim 1 wherein the heterochain polymer is selected from the group consisting of absorbable polyester, polyester-carbonate, polyether-carbonate, and polyether-ester. 3. A curable, liquid, cyanoacrylate-based composition as in claim 1 wherein the heterochain polymer is a polyether selected from the group consisting of polyethylene glycol, polypropylene glycol, and a block copolymer of polyethylene glycol and polypropylene glycol. 4. A curable, liquid, cyanoacrylate-based composition as in claim 1 admixed with a monomer selected from the group consisting of alkyl-cyanoacrylate and alkoxyalkyl-cyanoacrylate. 5. A curable, liquid, cyanoacrylate-based composition as in claim 1 wherein the cyanoacrylate-capping is achieved with greater than 10 ppm of pyrophosphoric or polyphosphoric acid. 6. A curable, liquid, cyanoacrylate-based composition as in claim 2 wherein the cyanoacrylate-capping is achieved with greater than 10 ppm of pyrophosphoric or polyphosphoric acid. 7. A curable, liquid, cyanoacrylate-based composition as in claim 3 wherein the cyanoacrylate-capping is achieved with greater than 10 ppm of pyrophosphoric or polyphosphoric acid. 8. A curable, liquid, cyanoacrylate-based composition as in claim 4 wherein the cyanoacrylate-capping is achieved with greater than 10 ppm of pyrophosphoric or polyphosphoric acid. 9. A curable, liquid, cyanoacrylate-based composition as in claim 1 colored with an organic dye. 10. A curable, liquid, cyanoacrylate-based composition as in claim 6 colored with an organic dye. 11. A curable, liquid, cyanoacrylate-based composition as in claim 1 wherein the cyanoacrylate-capped heterochain polymer having at least two hydroxy end groups per chain is made by a method comprising the step of reacting a heterochain polymer with a member selected from the group consisting of an alkyl cyanoacrylate and a substituted alkyl cyanoacrylate in the presence of pyrophosphoric or polyphosphoric acid. 12. A curable, liquid, cyanoacrylate-based composition as in claim 11 wherein the heterochain polymer is reacted with an alkyl cyanoacrylate. 13. A curable, liquid, cyanoacrylate-based composition as in claim 12 wherein the alkyl cyanoacrylate comprises ethyl cyanoacrylate. 14. A curable, liquid, cyanoacrylate-based composition as in claim 11 wherein the heterochain polymer is reacted with an alkyl substituted cyanoacrylate. 15. A curable, liquid, cyanoacrylate-based composition as in claim 14 wherein the alkyl substituted cyanoacrylate comprises methoxypropyl cyanoacrylate. 16. A curable, liquid, cyanoacrylate-based composition as in claim 1 employed for topical application as a tissue adhesive or sealant. 17. A curable, liquid, cyanoacrylate-based composition as in claim 1 that is radiochemically sterilized for use as a sterile adhesive or sealant in repairing compromised internal organs or tissues.
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