[미국특허]
Methods for concurrently processing multiple biological chip assays
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12Q-001/68
C12M-001/34
C07H-021/04
출원번호
US-0157252
(2002-05-28)
발명자
/ 주소
Rava, Richard P.
Fodor, Stephen P. A.
Trulson, Mark
Norviel, Vernon A.
출원인 / 주소
Affymetrix, Inc.
대리인 / 주소
Hamilton, Brook, Smith & Reynolds, P.C.
인용정보
피인용 횟수 :
20인용 특허 :
19
초록▼
Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a molecular probe array; introducing samples into the test wells; subjecting the biological chip plate to mani
Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a molecular probe array; introducing samples into the test wells; subjecting the biological chip plate to manipulation by a fluid handling device that automatically performs steps to carry out reactions between target molecules in the samples and probes; and subjecting the biological chip plate to a biological chip plate reader that interrogates the probe arrays to detect any reactions between target molecules and probes.
대표청구항▼
Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a molecular probe array; introducing samples into the test wells; subjecting the biological chip plate to mani
Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a molecular probe array; introducing samples into the test wells; subjecting the biological chip plate to manipulation by a fluid handling device that automatically performs steps to carry out reactions between target molecules in the samples and probes; and subjecting the biological chip plate to a biological chip plate reader that interrogates the probe arrays to detect any reactions between target molecules and probes. Hoogenboom, H.R., et al., "Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains," Nucl. Acids Res. 19:4133-4137 (1991). Jaffe, A., et al., "Effects of the ccd Function of the F Plasmid on Bacterial Growth," J. Bacteriol. 163:841-849 (1985). Kanaar, R., et al., "Gin-Mediated Recombination of Catenated and Knotted DNA Substrates: Implications for the Mechanism of Interaction Between Cis-Acting Sites," Cell 58:147-159 (1989). Kilby, N. J., et al., "Site-specific recombinases: tools for genome engineering," Trends in Genetics 9:413-421 (1993). Kim, et al., "Lambda Int protein between higher complexes at two distant chromosomal loci attL and attR," Science 256:198-263 (1992). Kozak, M., "Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles," Microbiol. Rev. 47:1-45 (1983). Kozak, M., "An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs," Nucl. Acids res. 15:8125-8132 (1987). Kozak, M., "Structural features in eukaryotic mRNAs that modulate the initiation of translation," J. Biol. Chem 266:19867-19870 (1991). Kuhn, R., et al., "Inducible Gene Targeting in Mice," Science 269:1427-1429 (Sep. 1995). Lafontaine, D., and Tollervey, D., "One-step PCR mediated strategy for the construction of conditionally expressed and epitope tagged yeast proteins," N
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