Substantially linear olefin polymers having a melt flow ratio, I10/I2, ≧5.63, a molecular weight distribution, Mw/Mn, defined by the equation: Mw/Mn≦(I10/I2)−4.63, and a critical shear stress at onset of gross melt fracture of greater than about 4×106dyne/cm2and their method of manufactu
Substantially linear olefin polymers having a melt flow ratio, I10/I2, ≧5.63, a molecular weight distribution, Mw/Mn, defined by the equation: Mw/Mn≦(I10/I2)−4.63, and a critical shear stress at onset of gross melt fracture of greater than about 4×106dyne/cm2and their method of manufacture are disclosed. The substantially linear olefin polymers preferably have at least about 0.01 long chain branches/1000 carbons and a molecular weight distribution from about 1.5 to about 2.5. The new polymers have improved processability over conventional olefin polymers and are useful in producing fabricated articles such as fibers, films, and molded parts.
대표청구항▼
Substantially linear olefin polymers having a melt flow ratio, I10/I2, ≧5.63, a molecular weight distribution, Mw/Mn, defined by the equation: Mw/Mn≦(I10/I2)−4.63, and a critical shear stress at onset of gross melt fracture of greater than about 4×106dyne/cm2and their method of manufactu
Substantially linear olefin polymers having a melt flow ratio, I10/I2, ≧5.63, a molecular weight distribution, Mw/Mn, defined by the equation: Mw/Mn≦(I10/I2)−4.63, and a critical shear stress at onset of gross melt fracture of greater than about 4×106dyne/cm2and their method of manufacture are disclosed. The substantially linear olefin polymers preferably have at least about 0.01 long chain branches/1000 carbons and a molecular weight distribution from about 1.5 to about 2.5. The new polymers have improved processability over conventional olefin polymers and are useful in producing fabricated articles such as fibers, films, and molded parts. Gly-Phe-X2n(SEQ ID NO:2) wherein X 1and X2are each selected from the group consisting of L- or D-Arg, His, Lys and Tyr, and m and n are each 0, 1, 2 or 3 with the proviso that at least m or n is 1; a cyclic disulfide thereof or an organic or inorganic acid addition salt thereof. 2. A pharmaceutical composition for use in the treatment of obesity in an animal, which comprises an effective amount of a peptide according to claim 1, together with one or more pharmaceutically acceptable carriers and/or diluents.3. A peptide which is selected from the group consisting of Lau Arg Ile Val Gln Pen Arg Ser Val Glu Gly Ser Pen Gly Phe (SEQ ID NO: 15), CH 3CO-Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 8), H—leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 12), Lou Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe—CONH 2(SEQ ID NO: 7), Leu Arl Ile Val Gln Cys Lys Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 10), Leu Arg Ile Val Gln Cys Lys Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 11), Tyr Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 19), Lys Leu Arg Ile Val Gln Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 20), Lys Lys Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 33), Ala Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 22), Leu Lys Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 21), Leu Arg Ala Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 23), Leu Arg Lys Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 6), Leu Arg Ile Ala Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 24), Leu Arg Ile Val Ala Cys Arg Ser Val Glu Gly Ser Cys Gly Phe (SEQ D NO: 25), Leu Arg Ile Val Gln Cys Arg Ala Val Glu Gly Ser Cys Gly Phe (SEQ ID NO: 27), Leu Arg Ile Val Gln Cys Arg Ser Ala Glu Gly Ser Cys Gly Phe (SEQ ID NO: 28), Leu Arg Ile Val Gln Cys Arg Ser Val Glu Ala Ser Cys Gly Phe (SEQ ID NO: 30), Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ala Cys Gly Phe (SEQ ID NO: 31), Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Ala Phe (SEQ ID NO: 17), Leu Arg Ile Val Gln Cys Arg Ser Val Glu D-Ala Ser Cys D-Ala Phe (SEQ ID NO: 14), and Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Ala (SEQ ID NO: 16), wherein all amino acids, except for glycine, are of the L-absolute configuration, unless indicated as D-absolute configuration, and the peptide has a cyclic disulfide bond between Cys(182) and Cys(189) or Pen(182) and Pen(189) as appropriate, or an organic or inorganic acid addition salt thereof. 4. A pharmaceutical composition for use in the treatment of obesity in an animal, which comprise an effective amount of a peptide according to claim 3, together with one or more pharmaceutically acceptable carries and/or diluents.5. A peptide which comprises an analogue of the carboxyl-terminal sequence of a growth hormone, said analog comprising the amino acid sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (SEQ ID NO:19) wherein all amino acids, except for glycine, are of the L-absolute configuration, unless indicated as D-absolute configuration, and the peptide has a cyclic disulfide bond between Cys(182) and Cys(189) or an organic or inorganic acid addition salt thereof. 6. A peptide according to claim 5, sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (SEQ ID NO:19). 7. A pharmaceutical composition for use in the treatment of obesity in an animal, which comprises an effective amount of a peptide according to claim 6, together with one or more pharmaceutically acceptable carriers and diluents.8. A pharmaceutical composition for use in the treatment of obesity in an animal, which comprises an effective amount of a peptide according to claim 5, together with one or more pharmaceutically acceptable carriers and diluents.
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