IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0120400
(2002-04-12)
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발명자
/ 주소 |
- Hickey, Timothy
- Stewart, Ubonwan A.
- Jonn, Jerry
- Bobo, John S.
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| 출원인 / 주소 |
- Closure Medical Corporation
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| 대리인 / 주소 |
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| 인용정보 |
피인용 횟수 :
31 인용 특허 :
39 |
초록
▼
A method of making a sterile adhesive composition includes placing a mixture of a polymerizable adhesive monomer and a thickening agent in a container, sealing the container, and sterilizing the mixture and the container. The method provides superior viscosity for the monomer composition. An adhesiv
A method of making a sterile adhesive composition includes placing a mixture of a polymerizable adhesive monomer and a thickening agent in a container, sealing the container, and sterilizing the mixture and the container. The method provides superior viscosity for the monomer composition. An adhesive composition includes 2-octyl cyanoacrylate and at least one thickener. The sterile adhesive composition is particularly useful as a medical adhesive and can comprise 1,1-disubstituted ethylene monomers, such as α-cyanoacrylates.
대표청구항
▼
1. A method of making a sterile adhesive composition comprising: (a) placing a mixture comprising a polymerizable 1,1-disubstituted ethylene monomer and a thickening agent in a container, wherein said thickening agent is soluble in said monomer at room temperature, (b) sealing said container, a
1. A method of making a sterile adhesive composition comprising: (a) placing a mixture comprising a polymerizable 1,1-disubstituted ethylene monomer and a thickening agent in a container, wherein said thickening agent is soluble in said monomer at room temperature, (b) sealing said container, and (c) sterilizing the mixture in the container. 2. The method of claim 1, wherein said monomer is at least one member selected from the group consisting of n-butyl cyanoacrylate, 2-octyl cyanoacrylate, and ethyl cyanoacrylate.3. The method of claim 1, wherein said thickening agent is selected from the group consisting of poly(2-ethylhexyl methacrylate), poly(2-ethylhexyl acrylate), cellulose acetate butyrate and lactic acid-caprolactone copolymer.4. The method of claim 3, wherein said thickening agent is poly(2-ethylhexyl methacrylate).5. The method of claim 3, wherein said thickening agent is poly(2-ethylhexyl acrylate).6. The method of claim 3, wherein said thickening agent is cellulose acetate butyrate.7. The method of claim 3, wherein said thickening agent is lactic acid-caprolactone copolymer.8. The method of claim 1, wherein said thickening agent is biodegradable.9. The method of claim 1, wherein said thickening agent is a lactic acid-caprolactone copolymer.10. The method of claim 1, wherein said thickening agent comprises from about 0.5-25.0% by weight of the composition.11. The method of claim 1, wherein said thickening agent comprises from about 1.0-10.0% by weight of the composition.12. The method of claim 1, wherein said thickening agent comprises from about 1.0-5.0% by weight of the composition.13. The method of claim 1, wherein said thickening agent has a molecular weight of at least 100,000.14. The method of claim 1, wherein said thickening agent has a molecular weight of at least 500,000.15. The method of claim 1, wherein said thickening agent has a molecular weight of at least 1,000,000.16. The method of claim 1, wherein said sterilizing is performed by dry heat, gamma irradiation, electron beam irradiation, or microwave irradiation.17. The method of claim 1, wherein said sterilizing is performed by dry heat.18. The method of claim 1, wherein said sterilizing is performed by gamma irradiation.19. The method of claim 1, wherein said sterilizing is performed by electron beam irradiation.20. The method of claim 1, wherein said composition has a viscosity of about 20-500 centipoise.21. The method of claim 1, wherein said composition has a viscosity of about 30-400 centipoise.22. The method of claim 1, wherein said mixture further comprises acidic stabilizing agents.23. The method of claim 1, wherein said mixture further comprises a plurality of stabilizing agents.24. The method of claim 1, wherein said mixture further comprises plasticizing agents.25. The method of claim 1, wherein said container is made from at least one material selected from the group consisting of glass, plastic, and metal.26. The method of claim 1, wherein said container is made from plastic.27. The method of claim 1, wherein said container is made from glass.28. The method of claim 1, wherein viscosity of the mixture after sterilization is greater than the viscosity of the mixture before sterilization.29. The method of claim 1, wherein viscosity of the mixture after sterilization is less than 100% greater than the viscosity before sterilization.30. The method of claim 1, wherein said monomer is an α-cyanoacrylate.31. The method of claim 1, wherein said monomer is an α-cyanoacrylate of the formulawherein R 2is hydrogen and R3is a group having the formulawherein R 7iswherein n is 1-10 and R 8is an organic moiety.32. The method of claim 1, wherein said thickening agent comprises poly(caprolactone+DL-lactide+glycolide).33. The method of claim 1, wherein said thickening agent is poly(vinyl acetate).34. The method of claim 33, wherein said monomer is 2-octyl cyanoacrylate.
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