IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0898006
(2001-07-05)
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발명자
/ 주소 |
- Badejo, Ibraheem
- Hedgpeth, Daniel L.
- Narang, Upvan
- Nicholson, William S. C.
- Rivera, Andres
- Rivera, Mary Jo S.
- Sherbondy, Anthony
- Szabo, Gabriel N.
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출원인 / 주소 |
- Closure Medical Corporation
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
35 인용 특허 :
68 |
초록
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A method of treating or preventing tinea pedis, commonly known as Athlete's Foot, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea pedis, optionally with at least one of an additional anti-fungal agent or a foot care additive, a
A method of treating or preventing tinea pedis, commonly known as Athlete's Foot, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea pedis, optionally with at least one of an additional anti-fungal agent or a foot care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.
대표청구항
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1. A method of treating tinea pedis, comprising: a) applying an adhesive composition comprising a polymerizable monomer to an area of skin, wherein said area of skin is afflicted with tinea pedis; and b) allowing said polymerizable monomer composition to polymerize to form a polymer film over s
1. A method of treating tinea pedis, comprising: a) applying an adhesive composition comprising a polymerizable monomer to an area of skin, wherein said area of skin is afflicted with tinea pedis; and b) allowing said polymerizable monomer composition to polymerize to form a polymer film over said area of skin wherein said polymerizable composition comprises an α-cyanoacrylate monomer. 2. The method of claim 1, wherein said polymerizable monomer composition is an α-cyanoacrylate monomer.3. The method of claim 1, wherein said monomer composition comprises at least one member selected form the group consisting of ethyl cyanoacrylate, butyl cyanoacrylate, and 2-octyl cyanoacrylate.4. The method of claim 1, further comprising combining at least one of an anti-fungal agent or a foot care additive wit the polymerizable monomer composition on the area so that the at least one agent or additive serves as a polymerization initiator for said polymerizable monomer composition.5. The method of claim 1, wherein said composition further comprises at least one stabilizing agent for said polymerizable monomer.6. The method of claim 5, wherein said stabilizing agent is also at least one of an anti-fungal agent or a foot care additive.7. The method of claim 1, wherein said composition comprises at least one plasticizer.8. The method of claim 7, wherein the plasticizer is selected from the group consisting of tributyl citrate, acetyl tributyl citrate, polymethylmethacrylate, polydimethylsiloxane and hexadimethylsilazane.9. The method of claim 1, wherein the composition further comprises at least one of an anti-fungal agent or a foot care additive.10. The method of claim 9, wherein the composition further comprises said at least one anti-fungal agent and said at least one anti-fungal agent is selected from the group consisting of parabens, cresols, azoles, allylamines, pollyenes, acidics, mercurials, quaternary ammonium compounds, and non-polymer-stabilized compounds.11. The method of claim 9, wherein the composition further comprises said at least one anti-fungal agent and said at least one anti-fungal agent is a paraben selected from the group consisting of alkyl parabens having an alkyl group of from 1-4 carbon atoms.12. The method of claim 9, twherein the composition further comprises said at least one anti-fungal agent and said at least one anti-fungal agent is selected from the group consisting of cresol, clotrimazole, tolnaftate, terbinafine and tioconazole.13. The method of claim 9, wherein the composition further comprises said at least one foot car additive and said at least one foot care additive is selected from the group consisting of miconazoler nitrate, providone iodine complex, eliquinol, haloprogin, tolnaftate and undercylenic acid and mixtures thereof.14. The method of claim 9, wherein the at least one anti-fungal agent or foot care additive is mixed with the polymerizable monomer composition immediately prior to applying the polymerizable monomer composition to the area of skin.15. The method of claim 9, wherein the at least one anti-fungal agent or foot care additive is mixed with the polymerizable monomer composition during manufacture of the polymerizable monomer composition.16. The method of claim 9, wherein the composition further comprises said at least one anti-fungal agent and said anti-fungals agent is a phenolic antioxidant.17. The method of claim 16, wherein said antioxidant is a stablizing agent for said monomer.18. The method of claim 9, wherein the composition further comprises said at least one anti-fungal agent and said anti-fungal agent is butylparaben.19. The method of claim 1, wherein said composition has a Sterility Assurance Level (SAL) of 10−3-10−6.20. The method of claim 1, further comprising applying at least one of an anti-fungal agent or a foot care additive to the area of skin before applying the adhesive composition.21. The method of claim 20, further comprising allowing the at le ast one applied anti-fungal agent or foot care additive to substantially dry before applying the adhesive composition.22. The method of claim 20, wherein the anti-fungal agent is applied and is selected from the group consisting of parabens, cresols, and non-polymer-stabilized compounds.23. The method of claim 20, wherein the anti-fungal agent is applied and is selected from the group consisting of alkyl parabens having an alkyl group of from 1-4 carbon atoms.24. The method of claim 20, wherein the anti-fungal is applied and is selected from the group consisting of elemental metals and metal compounds.25. The method of claim 20, wherein the anti-fungal agent is applied and further comprises at least one of a diluent and a carrier.26. The method of claim 20, wherein the anti-fungal agent is applied and is in the form of a liquid, a solid, a powder, or a cream.27. The method of claim 20, wherein the foot care additive is applied and is selected from the group consisting of miconazole nitrate, povidone iodine complex, cliquinol, haloprogin, tolnaftate and undecylenic acid and mixtures thereof.28. The method of claim 1, wherein said adhesive composition is applied directly to said area of skin, and said adhesive composition does not include an anti-fungal agent or a foot care additive.29. The method of claim 28, wherein said polymer film has anti-fungal effects at said area of skin.30. A method of treating tinea pedis, the method comprising the steps of: a. applying at least one of an anti-fungal agent or a foot care additive to an area of skin, wherein said area of skin is afflicted with tinea pedis; b. applying a polymerizable monomer composition to said area of skin over the at least one applied anti-fungal agent or foot care additive, wherein said composition comprises a 1,1-disubstituted ethylene monomer; and c. allowing said polymerizable monomer composition to polymerize to form a polymer film over said area of skin and said at least one anti-fungal agent or foot care additive. 31. A method of treating tinea pedis, the method comprising: a. combining a polymerizable monomer composition comprising a 1,1-disubstituted ethylene monomer and at least one of an anti-fungal agent or foot care additive to form a mixture; b. applying said mixture to an area of skin, wherein said area of skin is afflicted with tinea pedis; and c. allowing said mixture to polymerize to form at least one of an anti-fungal containing polymer film or a foot care additive containing polymer film over said area of skin. 32. The method of claim 1 wherein the adhesive composition is applied to the area of skin using a roller-type applicator.33. The method of claim 32, wherein the roller-type applicator comprises a movable element that rolls over the skin to apply the adhesive composition.34. The method of claim 33, wherein the moveable element has a shape selected from the group consisting of spherical, ellipsoid, and cylindrical.35. The method of claim 33, wherein the moveable element is coated with at least one of an anti-fungal agent, a foot care additive and an initiator.36. The method of claim 33, wherein, prior to application, the moveable element is separated from the adhesive composition by a frangible membrane.37. The method of claim 36, wherein the frangible membrane is ruptured so that the adhesive composition can be applied to the skin.38. The method of claim 33, wherein the moveable element is perforated.39. The method of claim 33, wherein the moveable element is perforated and contains an initiator packet within the moveable element that releases initiator when the adhesive composition is applied to the skin.40. The method of claim 1, wherein the adhesive composition is applied to the area of skin using a roller-type applicator, by securing a roller-ball member to a container that contains the composition so that a frangible membrane sealing an opening of the container is ruptured by the roller ball allowing the roller-ball to come in contact with the contained composition; and rolling the roller-ball over the area of skin so tat a volume of the composition coating a peripheral surface of the roller-ball is applied to the area of skin.41. The method of claim 9, wherein the adhesive composition comprising at least one of an anti-fungal agent or a foot care additive is applied to the area of skin using a roller-type applicator.
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