Triterpene compositions and methods for use thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/78
A61K-007/42
A61K-031/74
A01N-043/04
출원번호
US-0992837
(2001-11-16)
발명자
/ 주소
Arntzen, Charles J.
Gutterman, Jordan U.
출원인 / 주소
Research Development Foundation
대리인 / 주소
Fulbright & Jaworski L.L.P.
인용정보
피인용 횟수 :
15인용 특허 :
13
초록▼
The invention provides novel saponin mixtures and compounds which are isolated from the speciesAcacia victoriaeand methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures
The invention provides novel saponin mixtures and compounds which are isolated from the speciesAcacia victoriaeand methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
대표청구항▼
1. A method of inhibiting deleterious effects of ultraviolet light exposure to skin, comprising applying a safe and effective amount of a topical composition comprising a plant extract from Acacia victoriaewherein the plant extract comprises a triterpene moiety attached to a monoterpene moiety havin
1. A method of inhibiting deleterious effects of ultraviolet light exposure to skin, comprising applying a safe and effective amount of a topical composition comprising a plant extract from Acacia victoriaewherein the plant extract comprises a triterpene moiety attached to a monoterpene moiety having the molecular formula:or a pharmaceutical formulation thereof, wherein a) R 1and R2are selected from the group consisting of hydrogen, C1-C5 alkyl, and an oligosaceharide; b) R 3is selected from the group consisting of hydrogen, hydroxyl, C1-C5 alkyl, C1-C5 alkylene, C1-C5 alkyl carbonyl, a sugar, and a monoterpene group; and c) the formula further comprises R 4, wherein R4is selected from the group consisting of hydrogen, hydroxyl, C1-C5 alkyl, C1-C5 alkylene, C1-C5 alkyl carbonyl, a sugar, C1-C5 alkyl ester, and a monoterpene group, and wherein R4may be attached to the triterpene moiety or the monoterpene moiety.2. The method of claim 1, wherein the plant extract is obtained from the pods or seeds ofAcacia victoriae.3. The method of claim 1, wherein R3is a sugar.4. The method of claim 3, wherein the sugar is selected from the group consisting of glucose, fucose, rhamnose, arabinose, xylose, quinovose, maltose, glucuronic acid, ribose, N-acetyl glucosamine, and galactose.5. The method of claim 3, wherein a monoterpene moiety is attached to the sugar.6. The method of claim 5, wherein R3has the following formulawherein R5 is selected from the group consisting of hydrogen, hydroxyl, C1-C5 alkyl, C1-C5 alkylene, C1-C5 alkyl carbonyl, a sugar, C1-C5 alkyl ester, and a monoterpene group. 7. The method of claim 6, wherein R5is a hydrogen or a hydroxyl.8. The method of claim 1, wherein R1and R2each comprise an oligosaccharide.9. The method of claim 8, wherein R1and R2each comprise a monosaccharide, a disaccharide, a trisaccharide or a tetrasaccharide.10. The method of claim 9, wherein R1and R2each comprise an oligosaccharide comprising sugars which are separately and independently selected from the group consisting of glucose, fucose, rhamnose, arabinose, xylose, quinovose, maltose, glucuronic acid, ribose, N-acetyl glucosamine, and galactose.11. The method of claim 10, wherein at least one sugar is methylated.12. The method of claim 1, wherein R4is attached to the triterpene moiety through one of the methylene carbons attached to the triterpene moiety.13. The method of claim 1, wherein the triterpene moiety is oleanolic acid instead of acacic acid.14. The method of claim 1, wherein the pharmaceutical composition comprises a triterpene glycoside having the molecular formula:or a pharmaceutical formulation thereof, wherein a) R 1is an oligosaccharide comprising N-acetyl glucosamine, fucose and xylose; and b) R 2is an oligosaccharide comprising glucose, arabinose and rhamnose.15. The method of claim 14, wherein the triterpene glycoside has molecular formula:or a pharmaceutical formulation thereof.
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