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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0945704 (2001-09-05) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 489 인용 특허 : 67 |
The present invention relates in general to implantable, resorbable copolymers containing L-lactide and glycolide repeat units, and in particular to terpolymers containing L-lactide, glycolide, and one other type of repeat unit selected from the group consisting of D-lactide, D,L-lactide, and &egr;-
The present invention relates in general to implantable, resorbable copolymers containing L-lactide and glycolide repeat units, and in particular to terpolymers containing L-lactide, glycolide, and one other type of repeat unit selected from the group consisting of D-lactide, D,L-lactide, and &egr;-caprolactone. Medical devices for in vivo implantation applications containing such implantable, resorbable copolymers are also described, as well as methods for making such copolymers and devices.
1. An implantable medical device comprising a terpolymer having repeat units of L-lactide, D-lactide, and glycolide and that is made by the process comprising: contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, D-lactide, and glycolide
1. An implantable medical device comprising a terpolymer having repeat units of L-lactide, D-lactide, and glycolide and that is made by the process comprising: contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, D-lactide, and glycolide to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers; polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer. 2. The device of claim 1, which is fabricated into the form of a bone fixation plate, screw, tack, clip, staple, pin, rod, anchor, scaffold, sponge, implant for cell encapsulation, implant for tissue engineering, drug delivery device, monofilament or multifilament structure, sheet, membrane, and a foamed article.3. The device of claim 1, wherein from about 1% to about 20% of the repeat units of the terpolymer are D-lactide repeat units.4. The device of claim 3, wherein from about 4% to about 11% of the repeat units of the terpolymer are D-lactide repeat units.5. The device of claim 1, wherein from about 50% to about 95% of the repeat units of the terpolymer are L-lactide repeat units.6. The device of claim 5, wherein from about 75% to about 90% of the repeat units of the terpolymer are L-lactide repeat units.7. The device of claim 1, wherein from about 1% to about 30% of the repeat units of the terpolymer are glycolide repeat units.8. The device of claim 7, wherein from about 4% to about 18% of the repeat units of the terpolymer are glycolide repeat units.9. The device of claim 1, wherein the terpolymer comprises from about 75% to about 90% L-lactide repeat units, from about 4% to about 11% D-lactide repeat units, and from about 4% to about 18% glycolide repeat units.10. The device of claim 1, wherein the terpolymer consists essentially of about 85% L-lactide repeat units, about 5% D-lactide repeat units, and about 10% glycolide repeat units.11. The device of claim 1, wherein the terpolymer consists essentially of about 90% L-lactide repeat units, about 5% D-lactide repeat units, and about 5% glycolide repeat units.12. An implantable medical device comprising a terpolymer having repeat units of L-lactide, D,L-lactide, and glycolide and that is made by the process comprising: contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, D,L-lactide, and glycolide to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers; polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer. 13. The device of claim 12, wherein the terpolymer comprises at least about 50% L-lactide repeat units, from about 1% to about 20% D,L-lactide repeat units, and from about 1% to about 30% glycolide repeat units.14. The device of claim 12, wherein the terpolymer consists essentially of about 80% L-lactide repeat units, about 10% D,L-lactide repeat units, and about 10% glycolide repeat units.15. The device of claim 12, wherein the terpolymer consists essentially of about 80% L-lactide repeat units, about 5% D,L-lactide repeat units, and about 15% glycolide repeat units.16. An implantable medical device consisting essentially of a terpolymer having repeat units of about 80% L-lactide, about 10% &egr;-caprolactone, and about 10% glycolide and that is made by the process comprising: contacting a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, &egr;-caprolactone, and glycolide to form a monomer-dimer mixture; and polymerizing substantially all of the monomer-dimer mixture to form the terpolymer. 17. The device of claim 1, wherein the terpolymer has a heat of fusion from about 0.5 J/g to about 15 J/g.18. The device of claim 1, wherein the terpolymer has a heat of fusion f rom about 0.1 J/g to about 10 J/g.19. The device of claim 1, wherein the terpolymer has a heat of fusion from about 15 J/g to about 25 J/g.20. The device of claim 1, wherein the terpolymer has an inherent viscosity from about 2.5 dL/g to about 8 dL/g.21. The device of claim 1, wherein the terpolymer has an inherent viscosity from about 4 dL/g to about 6.5 dL/g.22. An implantable medical device comprising a terpolymer having repeat units depicted by the following formula: wherein the repeat unit having subscript x is an L-lactide repeat unit, the third component having subscript y is a D-lactide repeat unit; the molar percentages of the repeating units are such that x is from about 0.75 to about 0.9, y is from about 0.02 to about 0.16, and z is from about 0.04 to about 0.18; and x+y+z=1; and wherein the terpolymer is made by the process comprising: contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, glycolide, and either D-lactide or D,L-lactide, to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers;polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer.23. The device of claim 22, wherein x is from about 0.75 to about 0.9, y is from about 0.04 to about 0.11, and z is from about 0.05 to about 0.15.24. The device of claim 22, wherein x is essentially about 0.85, y is essentially about 0.05, and z is essentially about 0.1.25. The device of claim 22, wherein x is essentially about 0.9, y is essentially about 0.05, and z is essentially about 0.05.26. An implantable medical device comprising the terpolymer of claim 1 made by the process comprising: combining L-lactide dimer, D-lactide dimer, and glycolide dimer to form a dimer mixture; polymerizing substantially all of the dimer mixture to form the terpolymer. 27. An implantable medical device comprising the terpolymer of claim 12 made by the process comprising: combining L-lactide dimer, D,L-lactide dimer, and glycolide dimer to form a dimer mixture; polymerizing substantially all of the dimer mixture to form the terpolymer. 28. A terpolymer comprising from about 75% to about 90% L-lactide repeat units, from about 4% to about 11% D-lactide repeat units, and from about 4% to about 18% glycolide repeat units, wherein the terpolymer is made by the process comprising: contacting dimers or a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, D-lactide, and glycolide to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers; polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer. 29. The terpolymer of claim 28, which consists essentially of about 90% L-lactide repeat units, about 5% D-lactide at units, and about 5% glycolide repeat units.30. The terpolymer of claim 28, which consists essentially of about 85% L-lactide repeat units, about 5% D-lactide repeat units, and about 10% glycolide repeat units.31. A terpolymer comprising about 80% L-lactide repeat units, about 10% repeat units from &egr;-caprolactone, and about 10% glycolide repeat units, wherein the terpolymer is made by the process comprising: contacting a combination of monomers and dimers that correspond to repeat unit structures of L-lactide, &egr;-caprolactone, and glycolide to form a monomer-dimer mixture; polymerizing substantially all of the monomer-dimer mixture to form the terpolymer. 32. A terpolymer comprising at least about 50% L-lactide repeat units, from about 1% to about 20% D,L-lactide repeat units, and from about 1% to about 30% glycolide repeat units, wherein the terpolymer is made by the process comprising: contacting dimers or a combination of monomers and dimers that correspond to repeat unit structur es of L-lactide, D,L-lactide, and glycolide to form a dimer or monomer-dimer mixture, wherein at least a portion of the L-lactide repeat units are supplied by L-lactide dimers or by L-lactic acid monomers; polymerizing substantially all of the dimer or monomer-dimer mixture to form the terpolymer. 33. The terpolymer of claim 32, which consists essentially of about 80% L-lactide repeat units, about 10% D,L-lactide repeat units, and about 10% glycolide repeat units.34. The terpolymer of claim 32, which consists essentially of about 80% L-lactide repeat units, about 5% D,L-lactide repeat units, and about 15% glycolide repeat units.
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