IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0016614
(2001-10-30)
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발명자
/ 주소 |
- Kim, Enoch
- Xia, Younan
- Mrksich, Milan
- Jackman, Rebecca J.
- Zhao, Xiao-Mei
- Smith, Stephen P.
- Prentiss, Mara G.
- Whitesides, George M.
- Marzolin, Christian
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출원인 / 주소 |
- President and Fellows of Harvard College
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대리인 / 주소 |
Wolf, Greenfield & Sacks, P.C.
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인용정보 |
피인용 횟수 :
15 인용 특허 :
34 |
초록
▼
Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active
Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraries, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of identical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.
대표청구항
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1. A method of creating a pattern of a species at a defined region proximate a substrate surface, comprising:providing an article having a contoured surface including at least one indentation defining a pattern;forming at a first region proximate a substrate surface, in a pattern corresponding to th
1. A method of creating a pattern of a species at a defined region proximate a substrate surface, comprising:providing an article having a contoured surface including at least one indentation defining a pattern;forming at a first region proximate a substrate surface, in a pattern corresponding to the indentation pattern, a fluid precursor of the species; andallowing the fluid precursor, comprising a solution or suspension of an inorganic compound, to harden at the first region of the substrate surface, in a pattern corresponding to the indentation pattern and in an area including a portion having a lateral dimension of less than about 1 mm, while leaving a second region proximate the substrate surface, contiguous with the first region, free of the species. 2. A method as in claim 1, wherein the fluid precursor comprises a suspension of particles in a fluid carrier and the allowing step comprises allowing the fluid carrier to dissipate thereby depositing the particles at the first region of the substrate surface. 3. A method as in claim 2, wherein the particles are microbeads. 4. A method as in claim 1, wherein the fluid precursor comprises a chemically active agent that is capable of promoting deposition of a metal. 5. A method as in claim 1, wherein the fluid precursor is a prepolymeric species, and the forming step comprises positioning the contoured surface of the article proximate the substrate surface thereby creating a channel defined by the at least one indentation and the first region of the substrate surface and allowing the prepolymeric species to flow into the channel via capillary action, and the allowing step comprises forming a polymeric article from the prepolymeric species. 6. A method as in claim 5, wherein the allowing step comprises allowing the prepolymeric species to form a polymeric article in an area including a portion having a lateral dimension of less than about 500 microns. 7. A method of promoting a chemical reaction at a defined region proximate a substrate surface, comprising:positioning an article proximate a substrate surface and applying, to a first region proximate the substrate surface via capillary action involving the article, a chemically active agent; andallowing a chemical reaction involving the chemically active agent to take place at the first region proximate the substrate surface. 8. A method as in claim 7, wherein the chemically active agent is a prepolymeric species and the allowing step comprises forming a polymeric article from the prepolymeric species. 9. A method as in claim 7, wherein the chemically active agent is coupled to a particulate carrier that is applied, in a fluid carrier via capillary action involving the article, to the first region proximate the substrate surface. 10. A method as in claim 9, wherein the particulate carrier comprises microbeads. 11. A method as in claim 7, the allowing step comprising allowing a chemical reaction to take place at the first region in an area including a portion having a lateral dimension of less than about one millimeter. 12. A method as in claim 11, the allowing step comprising allowing a chemical reaction to take place at the first region in an area including a portion having a lateral dimension of less than about 500 microns. 13. A method as in claim 12, wherein the allowing step comprises allowing a chemical reaction to take place at the first region in an area including a portion having a lateral dimension of less than about 100 microns. 14. A method as in claim 13, the allowing step comprising allowing a chemical reaction to take place at the first region in an area including a portion having a lateral dimension of less than about 50 microns. 15. A method as in claim 14, the allowing step comprising allowing a chemical reaction to take place at the first region in an area including a portion having a lateral dimension of less than about 20 microns. 16. A method as in claim 7, wherein the chemically active agent is a prepolym eric species and the allowing step comprises allowing the prepolymeric species to form a polymeric article at the first region in an area including a portion having a lateral dimension of less than about one millimeter. 17. A method as in claim 16, wherein the allowing step comprises allowing the prepolymeric species to form a polymeric article at the first region in an area including a portion having a lateral dimension of less than about 500 microns. 18. A method as in claim 7, the positioning step comprising positioning an article having a contoured surface including at least one indentation defining a pattern with the contoured surface proximate the substrate surface so as to form a channel defined by the at least one indentation and the first region and allowing the chemically active agent to enter the channel via capillary action so as to be positioned proximate the first region. 19. A method of creating a pattern of a species at a defined region proximate a substrate surface comprising:positioning a forming article proximate a substrate surface and applying, to a first region proximate the substrate surface via capillary action involving the article, a fluid precursor of the species;allowing the fluid precursor to harden to the extent that the species is self-supporting at the first region proximate the substrate surface; andremoving the forming article from the substrate surface. 20. A method of creating a pattern of a species at a defined region proximate a substrate surface, comprising:providing an article having a contoured surface including at least one indentation defining a pattern;transferring a fluid precursor of the species from the contoured surface of the article to a first region proximate a substrate surface to form at the first region, in a pattern corresponding to the indentation pattern, a fluid precursor of the species;allowing the fluid precursor to harden at the first region of the substrate surface, in a pattern corresponding to the indentation pattern, while leaving a second region proximate the substrate surface, contiguous with the first region, free of the species; andthen removing the article from the substrate surface. 21. A method as in claim 1, wherein the fluid precursor is a precursor of a reactive ion etch mask. 22. A method as in claim 21, the allowing step including allowing the fluid precursor to harden and to form a reactive ion etch mask at the first region of the substrate surface, the method further comprising exposing the substrate to reactive ion etch conditions and allowing at least a portion of the substrate surface at the second region to be etched by reactive ion etching. 23. A method comprising:providing an article having a contoured surface including at least one indentation defining a pattern;forming at a first region proximate a substrate surface, in a pattern corresponding to the indentation pattern, a fluid precursor of a reactive ion etch mask; andallowing the fluid precursor to harden to form a reactive ion etch mask at the first region of the substrate surface while leaving a second region proximate the substrate surface, contiguous with the first region, free of the species. 24. A method as in claim 23, involving allowing the fluid precursor to harden to form a reactive ion etch mask at the first region of the substrate surface in a pattern corresponding to the indentation pattern and in an area including a portion having a lateral dimension of less than about 1 mm. 25. A method as in claim 23, comprising forming the fluid precursor in the pattern on the surface by providing an amount of the fluid precursor on the substrate surface and pressing the contoured surface of the article into the precursor against the substrate surface. 26. A method as in claim 23, further comprising exposing the substrate to reactive ion etch conditions and allowing at least a portion of the substrate surface at the second region to be etched by reactive ion etching. 27. A method as in cl aim 23, wherein the surface is nonplanar. 28. A method as in claim 1, wherein the forming step comprises applying a vacuum in a channel, defined by the at least one indentation and the first region, to urge the fluid processor to flow therein.
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