초록 ▼

An ablation catheter stores a platelet inhibitor substance within a plurality of pockets or recesses of its shaft. The substance is adapted to elute upon contact with biological fluid. In the pocket configuration, the platelet inhibitor substance is in a capsule positioned within the pocket. In the

An ablation catheter stores a platelet inhibitor substance within a plurality of pockets or recesses of its shaft. The substance is adapted to elute upon contact with biological fluid. In the pocket configuration, the platelet inhibitor substance is in a capsule positioned within the pocket. In the recess configuration, the platelet inhibitor substance is in a hydrogel or silicone-based porous/semi-porous matrix positioned within the recess. Elution of the platelet inhibitor substance prevents or at least substantially minimizes the adhesion of blood platelets on the catheter surface during ablation. In another configuration, the catheter includes an internal lumen network having apertures terminating at the surface of the shaft. The lumen communicates with a source of platelet inhibitor fluid that is forced through the lumen by a variable pump.

대표청구항 ▼

1. A method of applying energy to biological tissue within a biological site having biological fluid therein, said method comprising:positioning a catheter having at least one electrode and at least one pocket having a length from about 0.5 mm to about 2 mm carried by die catheter and having an open

1. A method of applying energy to biological tissue within a biological site having biological fluid therein, said method comprising:positioning a catheter having at least one electrode and at least one pocket having a length from about 0.5 mm to about 2 mm carried by die catheter and having an opening terminating at the outside surface of the catheter, within the biological site so that the electrode is adjacent the tissue to be ablated; andapplying RF energy to the at least one electrode;wherein the pocket is filled with a platelet inhibitor substance adapted to elute upon contact with the biological fluid. 2. The method of claim 1 wherein the at least one pocket is carried by a tubular wall of the catheter. 3. The method of claim 2 wherein the at least one pocket is within the tubular wall. 4. The method of claim 2 wherein the at least one pocket is within the lumen defined by the tubular wall. 5. The method of claim 1 wherein the at least one pocket is carried by the at least one electrode. 6. The method of claim 1 further comprising depositing the platelet inhibitor substance in the pockets under pressure using an extrusion process. 7. The method of claim 1 wherein the platelet inhibitor substance comprises a tablet-like capsule. 8. The method of claim 7 wherein the tablet-like capsule comprises 100% of a platelet inhibitor drug. 9. The method of claim 1 wherein the at least one pocket comprises an elongate aperture. 10. The method of claim 1 wherein the at least one pocket comprises a plurality of pockets each having an aperture, the apertures for the plurality of pockets being substantially the same size. 11. The method of claim 1 wherein the at least one pocket comprises a plurality of pockets each having an aperture, the apertures for the plurality of pockets decreasing in size along the length of the catheter. 12. The method of claim 1 further comprising depositing a layer of a mixture of heparin and sugar-based solution over the platelet inhibitor substance. 13. A method of applying energy to biological tissue within a biological site having biological fluid therein, said method comprising:positioning a catheter having at least one electrode and at least one recess having a length from about 0.5 mm to about 2 mm carried by the catheter and having an opening terminating at the outside surface of the catheter, within the biological site so that the electrode is adjacent the tissue to be ablated; andapplying energy to the at least one electrode;wherein the recess is filled with a matrix having a platelet inhibitor substance dispersed therein that is adapted to elute upon contact with the biological fluid. 14. The method of claim 13 wherein the matrix is a porous/semi-porous silicone. 15. The method of claim 13 wherein the platelet inhibitor substance is uniformly dispersed in a porous/semi-porous hydrogel matrix. 16. The method of claim 13 further comprising depositing the platelet inhibitor substance in the recess under pressure using an extrusion process. 17. The method of claim 13 wherein the platelet inhibitor substance comprises a tablet-like capsule. 18. The method of claim 17 wherein the tablet-like capsule comprises 100% of a platelet inhibitor drug. 19. The method of claim 13 wherein the at least one recess comprises an elongate aperture. 20. The method of claim 13 wherein the at least one recess comprises a plurality of recesses each having an aperture, the apertures for the plurality of recesses being substantially the same size. 21. The method of claim 13 wherein the at least one recess comprises a plurality of recesses each having an aperture, the apertures for the plurality of recesses decreasing in size along the length of the catheter. 22. The method of claim 13 further comprising depositing a layer of a mixture of heparin and sugar-based solution over the platelet inhibitor substance.