Anti-infective compositions, methods and systems for treating disordered tissue
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/155
A61K-031/24
A61K-031/045
출원번호
US-0200897
(2002-07-22)
발명자
/ 주소
Johnson, B. Ron
대리인 / 주소
Workman Nydegger
인용정보
피인용 횟수 :
8인용 특허 :
97
초록▼
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention relates to the use of an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitat
The present invention relates to the treatment of disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The invention relates to the use of an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and/or antimicrobial active agent comprises an organohalide, such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.
대표청구항▼
1. A treatment composition for application to and penetration into disordered tissue, the treatment composition comprising:at least two anti-infective quaternary ammonium halide compounds in a carrier, andwherein the treatment composition is a liquid comprising a tissue penetrating component for pen
1. A treatment composition for application to and penetration into disordered tissue, the treatment composition comprising:at least two anti-infective quaternary ammonium halide compounds in a carrier, andwherein the treatment composition is a liquid comprising a tissue penetrating component for penetrating skin in a rapid manner without rapidly diffusing beyond the skin. 2. A treatment composition as recited in claim 1, wherein the at least two quatemary ammonium compounds comprise at least one benzalkonium chloride compound. 3. A treatment composition as recited in claim 2, wherein said at least one benzalkonium chloride compound composes benzalkonium chloride with an n-alkyl chain length distribution of about 60% C 14 , about 30% C 16 , about 5% C 12 , and about 5% C 18 . 4. A treatment composition as recited in claim 1, wherein the carrier comprises isopropyl alcohol. 5. A treatment composition as recited in claim 1, wherein the carrier comprises isopropyl alcohol and water. 6. A treatment composition as recited in claim 1, wherein the carrier consists essentially of isopropyl alcohol and water. 7. A treatment composition as recited in claim 1, wherein the carrier comprises isopropyl alcohol and water, the water being in an amount ranging form about 20% to about 40% by volume of the carrier. 8. A treatment composition as recited in claim 1, wherein the carrier comprises an aqueous solution of isopropyl alcohol at a concentration of about 70% of isopropyl alcohol by volume of the carrier. 9. A treatment composition as recited in claim 1, wherein the carrier comprises an aqueous solution of isopropyl alcohol such that the isopropyl alcohol is present at a concentration by volume in the range from about 20% to about 80% of the carrier. 10. A treatment composition as recited in claim 1, wherein the treatment composition does not include any penetration inhibiting components. 11. A treatment composition as recited in claim 1, wherein the treatment composition penetrates into disordered tissue in a manner so that the treatment composition is no longer visibly detectable on the disordered tissue within about two minutes after application of the treatment composition onto the disordered tissue. 12. A treatment composition as recited in claim 1, wherein said at least two quatemary ammonium compounds comprise at least one n-dialkyl methyl benzyl ammonium halide. 13. A treatment composition as recited in claim 1, wherein said at least two quaternary ammonium compounds comprise at least one n-alkyl dimethyl ethylbenzyl ammonium halide. 14. A treatment composition as recited in claim 12, wherein said halide is a chloride. 15. A treatment composition as recited in claim 13, wherein said halide is a chloride. 16. A method for treating disordered tissue, comprising:identifying disordered tissue that comprises lesions caused by at least one of genital herpes, chicken pox and Herpes Zoster; andapplying to said disordered tissue a treatment composition for application to and penetration into said disordered tissue, wherein said treatment composition comprises:at least two anti-infective quaternary ammonium halide compounds in a carrier, andwherein the treatment composition is a liquid comprising a tissue penetrating agent for penetrating skin in a rapid manner without rapidly diffusing beyond the skin. 17. A method as recited in claim 16, wherein the at least two anti-infective quaternary ammonium halide compounds comprise at least one benzalkonium chloride compound. 18. A method as recited in claim 16, wherein the carrier comprises isopropyl alcohol. 19. A method as recited in claim 16, wherein the carrier comprises a hydroalcoholic solution of isopropyl alcohol at a concentration of about 70% of isopropyl alcohol by volume in the carrier. 20. A method as recited in claim 16, wherein said treatment composition does not include any penetration inhibiting components. 21. A method as recited in claim 16, wherein the treatment composition into disordered tissue in a manner so that the treatment composition is no longer visibly detectable on the disordered tissue within about two minutes after application of the treatment composition onto the disordered tissue. 22. A method as recited in claim 16, wherein said treatment composition is applied to said disordered tissue by rubbing. 23. A method as recited in claim 16, wherein said treatment composition is applied to said disordered tissue by vigorously agitating said disordered tissue. 24. A method as recited in claim 16, wherein the disordered tissue comprises genital herpes caused by herpes type 1 virus (HSV1). 25. A method as recited in claim 16, wherein the disordered tissue comprises genital herpes caused by herpes type 2 virus (HSV2). 26. A treatment composition for application to and penetration into disordered tissue, the treatment composition comprising:at least two anti-infective quatemary ammonium halide compounds in a carrier that have a combined concentration that is less than about 0.5% by weight of the treatment composition, andwherein the treatment composition is a liquid comprising a tissue penetrating component for penetrating skin in a rapid manner without rapidly diffusing beyond the skin. 27. A treatment composition for application to and penetration into disordered tissue, the treatment composition comprising:at least two anti-infective quaternary ammonium halide compounds in a carrier,the at least two anti-infective quatemary ammonium halide compounds comprising at least two members selected from the group consisting of benzalkonium chloride compounds, benzethonium chloride, methyl benzethonium chloride, cetyl pyridinium chloride, chloroxylenol, hexachlorophene, triclosan, chlorhexidine, alkylbenzyl dimethylammonium chloride, alkyldimetheyl ethyl benzylammonium chloride, n-alkyldimethylbenzylammonium chloride, n-alkyldimethylethylbenzyl ammonium chloride, n-dialkyl methylbenzylammonium chloride, diisobutyl phenoxyethoxy ethyldimethyl benzylammonium chloride, n-(C 12 C 14 C 16 ) alkyl dimethyl benzylammonium chloride, didecyldimethyl ammonium chloride, dioctyldimethyl ammonium chloride dialkyldimethyl ammonium chloride, dialkylmethylbenzyl ammonium chloride, octyldecyl dimethylammonium chloride, lauryldimethyl benzyl ammonium chloride, o-benzyl-p-chlorophenol, dideryldimethylammonium, dioctyl dimethyl ammonium chlorite, alkyl (C 14 C 12 C 16 ) dimethylbenzylammonium chloride, andwherein the treatment composition is a liquid comprising a tissue penetrating component for penetrating skin in a rapid manner without rapidly diffusing beyond the skin.
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