A composition for an infant formula which comprises a low threonine content; a method of producing the composition; use of the composition in the manufacture of a medicament or nutritional product for addressing the nutritional needs and providing healthy growth of an infant; and a method of address
A composition for an infant formula which comprises a low threonine content; a method of producing the composition; use of the composition in the manufacture of a medicament or nutritional product for addressing the nutritional needs and providing healthy growth of an infant; and a method of addressing the nutritional needs and providing healthy growth of an infant which comprises administering an effective amount of the composition. A preferred embodiment of the composition comprises all of: i) acid whey protein or sweet whey protein from which caseino-glyco-macropeptide has been removed; and ii) free arginine; and iii) free histidine; and iv) free tyrosine or free tryptophan or tryptophan rich milk protein or a mixture thereof.
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1. A composition for an infant formula comprising a protein which has a low threonine content, the composition comprising:a whey component selected from the group consisting of acid whey protein and sweet whey protein from which caseino-glyco-macropeptide has been removed;free arginine;free histidin
1. A composition for an infant formula comprising a protein which has a low threonine content, the composition comprising:a whey component selected from the group consisting of acid whey protein and sweet whey protein from which caseino-glyco-macropeptide has been removed;free arginine;free histidine; anda component selected from the group consisting of free tyrosine, free tryptophan, tryptophan based milk protein and mixtures thereof, wherein the low threonine content comprises less than about 8 g threonine/16 g nitrogen. 2. A composition according to claim 1 which comprises from about 9.0 to about 10.0 w/w % of protein. 3. A composition according to claim 1, wherein the protein comprises casein protein. 4. A composition according to claim 3, wherein the protein comprises about 6% to about 50% by weight of whey protein and about 20% to about 40% casein protein. 5. A composition according to claim 1, wherein the whey component is substantially free of lactose, wherein the level of lysine blockage is less than 10% in said protein. 6. A composition according to claim 1, wherein the protein has less than 10% blocked lysine. 7. A composition according to claim 1, wherein the protein comprises hydrolyzed protein. 8. A composition according to claim 7, wherein the protein comprises about 98.5% to about 97% by weight of hydrolyzed sweet whey protein and about 1.5% to about 3% by weight of arginine, tyrosine, and histidine. 9. A composition according to claim 1 which comprises:about 0.1% to about 3% by weight of free arginine;about 0.2% to about 1% by weight of a component selected from the group consisting of free tryptophan and free tyrosine; andabout 0.1% to about 1.5% by weight of histidine. 10. A composition according to claim 1 which comprises a lipid and a carbohydrate. 11. A composition according to claim 10, wherein the lipid comprises medium chain triglycerides. 12. A composition according to claim 10, wherein the carbohydrate includes lactose. 13. An infant formula comprising a protein having a low threonine content and comprising:a whey component selected from the group consisting of acid whey protein and sweet whey protein from which cascino-glyco-macropeptide has been removed;a component selected from the group consisting of free tyrosine, free tryptophan, tryptophan based milk protein and mixtures thereof;up to about 1.5% by weight histidine; andabout 0.1% to about 2% by weight arginine, wherein the low threonine content comprises less than about 8 g threonine/16 g nitrogen. 14. An infant formula according to claim 13, wherein the protein source comprises about 0.2% to about 0.4% by weight histidine, about 1% to about 2% by weight arginine, and about 0.2% to about 0.4% by weight tryptophan. 15. An infant formula according to claim 13, wherein the protein source comprises about 1% to about 1.5% by weight histidine, about 0.6% to about 0.9% by weight arginine, and about 0.3% to about 0.5% by weight tyrosine. 16. An infant formula according to claim 13, wherein the protein source comprises about 0.2% to about 0.4% by weight histidine, about 1% to about 2% by weight arginine, and about 0.2% to about 0.4% by weight tyrosine. 17. A method of producing an infant formula composition comprising the steps of:blending whey protein and casein protein together with free arginine, free histidine, and a component selected from the group consisting of free tyrosine, free tryptophan, tryptophan based milk protein and mixtures thereof, and homogenizing the blended mixture. 18. A method of providing a medicament to an infant comprising the step of administering to an infant a formula comprising:a protein source which has a threonine content less than about 8 g threonine/16 g nitrogen and comprising a whey component selected from the group consisting of acid whey protein and sweet whey protein from which caseino-glyco-macropeptide has been removed, free arginine, free histidine, a component selected from the group consisting of free tyros ine, free tryptophan, tryptophan based milk protein and mixtures thereof, and a medicament. 19. A method of providing nutrition to an infant comprising the step of administering to an infant a formula comprising:a protein source which has a threonine content less than about 8 g threonine/16 g nitrogen and comprising a whey component selected from the group consisting of acid whey protein and sweet whey protein from which caseino-glyco-macropeptide has been removed, free arginine, free histidine, a component selected from the group consisting of free tyrosine, free tryptophan, tryptophan based milk protein and mixtures thereof, and a nutritional agent. 20. An infant formula according to claim 13, wherein the protein source comprises up to about 0.1% by weight histidine, about 0.1% to about 0.3% by weight arginine, and about 0.3 to about 0.5% by weight tryptophan. 21. A method according to claim 17, wherein the whey component is substantially free of lactose, wherein the level of lysine blockage is less than 10% in said protein. 22. A method according to claim 17, wherein the infant formula comprises:about 0.1% to about 3% by weight of arginine;about 0.2% to about 1% by weight of a component selected from the group consisting of tryptophan and tyrosine; andabout 0.1 to about 1.5% by weight of histidine. 23. A method according to claim 17, wherein the infant formula comprises a lipid and a carbohydrate. 24. A method according to claim 18, wherein the protein source comprises casein protein. 25. A method according to claim 18, wherein the whey component is substantially free of lactose, wherein the level of lysine blockage is less than 10% in said protein. 26. A method according to claim 18, wherein the protein source comprises:about 0.1% to about 3% by weight of arginine;about 0.2% to about 1% by weight of a component selected from the group consisting of tryptophan and tyrosine; andabout 0.1% to about 1.5% by weight of histidine. 27. A method according to claim 18, wherein the formula comprises a lipid and a carbohydrate. 28. A method according to claim 19, wherein the protein source comprises casein protein. 29. A method according to claim 19, wherein the whey component is substantially free of lactose, wherein the level of lysine blockage is less than 10% in said protein. 30. A method according to claim 19, wherein the protein source comprises:about 0.1% to about 3% by weight of arginine;about 0.2% to about 1% by weight of a component selected from the group consisting of tryptophan and tyrosine; andabout 0.1% to about 1.5% by weight of histidine. 31. A method according to claim 19, wherein the formula comprises a lipid and a carbohydrate. 32. A method according to claim 19, wherein the protein source comprises about 0.2% to about 0.4% by weight histidine, about 1% to about 2% by weight arginine, and about 0.2% to about 0.4% by weight tryptophan. 33. A method according to claim 19, wherein the protein source comprises about 1% to about 1.5% by weight histidine, about 0.6% to about 0.9% by weight arginine, and about 0.3% to about 0.5% by weight tyrosine. 34. A method according to claim 19, wherein the protein source comprises about 0.2% to about 0.4% by weight histidine, about 1% to about 2% by weight arginine, and about 0.2% to about 0.4% by weight tyrosine. 35. A method according to claim 19, wherein the protein source comprises up to about 0.1% by weight histidine, about 0.1% to about 0.3% by weight arginine, and about 0.3% to about 0.5% by weight tryptophan.
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이 특허에 인용된 특허 (2)
Gaull Gerald E. (1107 Fifth Ave. New York NY 10028), Infant milk formula.
Martinez Sarah B. (Evansville IN) Leary ; Jr. H. Lee (Evansville IN) Nichols Debra J. (Evansville IN), Milk protein partial hydrolysate and infant formula containing same.
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