[특허]System for effecting smoking cessation

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-016/00 A24F-047/00
출원번호	US-0147390 (2002-05-15)
발명자 / 주소	Farr, Stephen J.
출원인 / 주소	Aradigm Corporation
대리인 / 주소	Bozicevic Karl
인용정보	피인용 횟수 : 32 인용 특허 : 25

초록 ▼

A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aerosolizing a formulation and contai

A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aerosolizing a formulation and containers of formulation. The formulation is comprised of nicotine in a pharmaceutically acceptable carrier. Preferably, a plurality of containers are produced wherein the concentration of nicotine in the different containers or different groups of containers is reduced. The patient uses containers with the highest concentration initially and gradually moves towards using containers with lower and lower concentrations of nicotine until the patient's dependence on nicotine is eliminated.

대표청구항 ▼

1. A method of treatment, comprising the steps of:(a) providing a system comprising:a device for creating aerosolized particles and configured to receive a container containing a pharmaceutical formulation to be aerosolized;a plurality of groups of containers for use with the device, wherein each co

1. A method of treatment, comprising the steps of:(a) providing a system comprising:a device for creating aerosolized particles and configured to receive a container containing a pharmaceutical formulation to be aerosolized;a plurality of groups of containers for use with the device, wherein each container within a group of containers contains a pharmaceutical formulation having the same concentration of nicotine and wherein each group of containers contains a pharmaceutical formulation having concentration of nicotine different from each of the other groups of containers;(b) over a first period of time, repeatedly using the device with a first group of containers to aerosolize the pharmaceutical formulation; and(c) over a second period of time, repeatedly using the device with a second group of containers to aerosolize the pharmaceutical formulation, wherein the concentration of nicotine in the second group of containers is less than the concentration of nicotine in the first group of containers. 2. The method of claim 1, further comprising:over any number of subsequent periods of time, using the device with successive groups of containers wherein the concentration of nicotine in the subsequently used groups of containers is gradually reduced with each group of containers used. 3. The method of claim 1 wherein the concentration of nicotine used during the first period of time is sufficient to produce an arterial nicotine plasma concentration within the patient which substantially corresponds to that achieved during cigarette smoking. 4. The method of claim 1 wherein the particles have a size in the range from about 0.5 to 12 μm. 5. A method of treatment, comprising the steps of:(a) providing a system comprising:a device for creating aerosolized particles and configured to receive a container containing a pharmaceutical formulation to be aersolized;a plurality of groups of containers for use with the device, wherein each container within a group of containers contains a pharmaceutical formulation having the same concentration of nicotine and wherein each group of containers contains a pharmaceutical formulation having concentration of nicotine different from each of the other groups of containers;(b) using the device with a first container of a first group of containers containing a pharmaceutical formulation having a first concentration of nicotine to aerosolize the pharmaceutical formulation;(c) allowing the patient to inhale the aerosolized particles of (b) thereby causing nicotine to directly enter the patient's arterial system from the patient's lungs;(d) repeating steps (b) and (c) once for any number of other containers of the first group of containers; and(e) repeating step (d) for any number of other groups of containers wherein the concentration of nicotine in the subsequently used groups of containers is gradually reduced. 6. The method of claim 5 wherein the concentration of nicotine used during the first occurrence of step (b) is sufficient to produce an arterial nicotine plasma concentration within the patient which substantially corresponds to that achieved during cigarette smoking. 7. The method of claim 5 wherein the particles have a size in the range from about 0.5 to 12 μm.

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이 특허에 인용된 특허 (25) 인용/피인용 타임라인 분석

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Albrechtsen Sten,DKX ; Orup-Jacobsen Lene,DKX ; Hansen Jens,DKX ; Mollgaard Birgitte,DKX, Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the ma.
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Gerth Donald L. (Cincinnati OH) Muckenfuhs Delmar R. (Middletown OH), Dosing device to provide vaporized medicament to the lungs as a fine aerosol.
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Ray Jon P. (12544 Judson Rd. San Antonio TX 78233) Turner James E. (307 Wayside San Antonio TX 78213) Ellis Michael P. (811 River Rd. San Antonio TX 78212) Oldham Ronald G. (1410 Tarton San Antonio T, Nicotine dispenser with polymeric reservoir of nicotine.
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Ray J. Philip (2929 Mossrock ; Ste. 130 San Antonio TX 78230), Nicotine dispensing device and method for the manufacture thereof.
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Hill Ira D. (Clay Court Locust NJ 07760), Nicotine dispensing device and methods of making the same.
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Hill Ira D. (Locust NJ), Nicotine impact modification.
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Hill Ira (Locust NJ) Malmborg Bengt E. (Helsingborg TX SEX) Oldham Ronald G. (San Antonio TX) Turner James E. (Atascosa TX) Ellis Michael P. (San Antonio TX) Andersson Sven-Brje (dAkra SEX), Nicotine-impermeable container and method of fabricating the same.
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Turner James E. (Atascosa TX) Ellis Michael P. (San Antonio TX) Oldham Ronald G. (San Antonio TX) Hill Ira (Locust NJ) Malmborg Bengt E. (Helsingborg SEX) Andersson Sven-Brje (dkra SEX), Nicotine-impermeable container and method of fabricating the same.
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Turner James E. (Atascosa TX) Ellis Michael P. (San Antonio TX) Oldham Ronald G. (San Antonio TX) Hill Ira (Locust NJ) Malmborg Bengt E. (Helsingborg SEX) Andersson Sven-Brje (dkra SEX), Nicotine-impermeable container and method of fabricating the same.
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Honeycutt Rufus H. (Macon GA), Non-combustible simulated cigarette device.
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Voges Robert Martin,AUX, Piezo inhaler.
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Von Wielligh Johannes Luow Kotze,ZAX, Product for assisting a smoker in giving up the habit.
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Ray Jon P. (12544 Judson Rd. San Antonio TX 78233), Simulated smoking device.
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Steiner Pierre G. (417 Sea Ridge Dr. La Jolla CA 92037), Tar-free smoking devices.
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Stenzler, Alex; Zamel, Noe; Slutsky, Arthur; Ellis, Steven, Inhalable nicotine formulations and methods of making and using the same.
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