[미국특허]
Antihelminthic anthraquinones and method of use thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01K-043/04
A61K-031/70
A61K-031/545
A61K-031/52
출원번호
US-0317906
(2002-12-12)
발명자
/ 주소
Cichewicz, Robert H.
Nair, Muraleedharan G.
McKerrow, James H.
출원인 / 주소
Board of Trustees of Michigan State University, The Regent of the University of California, The United States of America as represented by the Department of Veterans Affairs
대리인 / 주소
McLeod Ian C.
인용정보
피인용 횟수 :
3인용 특허 :
5
초록▼
Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula:wherein R 1 , R 2 , R 3 , and R 4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, a
Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula:wherein R 1 , R 2 , R 3 , and R 4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
대표청구항▼
1. A method of inhibiting a Schistosoma sp. which comprises:exposing the Schistosoma sp. to an inhibitory amount of at least one anthraquinone of the formula:wherein R 1 , R 2 , R 3 , and R 4 are each selected from the group consisting of hydrogen, hydroxy, halogen, alkyl, acetyl, alkene, alkyne
1. A method of inhibiting a Schistosoma sp. which comprises:exposing the Schistosoma sp. to an inhibitory amount of at least one anthraquinone of the formula:wherein R 1 , R 2 , R 3 , and R 4 are each selected from the group consisting of hydrogen, hydroxy, halogen, alkyl, acetyl, alkene, alkyne, aryl, cyclic, acid group, carbohydrate, and combinations thereof, R is selected from the group consisting of methyl, alkyl, aldehyde, hydroxymethyl, acid and carbohydrate groups each R containing 1 to 12 carbon atoms, and the halogen is selected from the group consisting of I, F, Br, and Cl. 2. The method of claim 1 wherein the anthraquinone has the formula:wherein R is selected from the group consisting of methyl, alkyl, acetyl, aldehyde, hydroxymethyl, acid and carbohydrate groups each R containing 1 to 12 carbon atoms. 3. The method of claim 1 wherein the anthraquinone is 1,2,8-trihydroxy-3-methyl anthraquinone. 4. The method of claim 1 wherein the anthraquinone is 1,2,8-trihydroxy-3-hydroxymethyl anthraquinone. 5. The method of claim 1 wherein the anthraquinone is inhibitory at a dosage of 1 to 1,000 micrograms per milliliter or gram of the carrier administered. 6. The method of claim 1 wherein the inhibition is in vitro. 7. The method of claim 1 wherein the inhibition is in vivo.
Gulliya Kirpal S. (Dallas TX) Pervaiz Shazib (Dallas TX) Matthews J. Lester (Dallas TX) Dowben Robert M. (Dallas TX) Newman Jospeh T. (Dallas TX) Forest Edward (Dallas TX), Method of treating with therapeutic composition comprising photoactive compound.
Gulliya Kirpal S. (Dallas TX) Pervaiz Shazib (Dallas TX) Matthews J. Lester (Dallas TX) Dowben Robert M. (Dallas TX) Newman Joseph T. (Dallas TX) Forest Edward (Dallas TX), Pre-activated therapeutic agents derived from photoactive compounds.
Gulliya Kirpal S. (Dallas TX) Pervaiz Shazib (Dallas TX) Matthews J. Lester (Dallas TX) Dowben Robert M. (Dallas TX) Newman Joseph T. (Dallas TX) Forest Edward (Dallas TX), Therapeutic compositions derived from photoactive compounds.
Nair, Muraleedharan G.; Dhananjeyan, Mugunthu R.; Kron, Michael A.; Milev, Youli P., Anthraquinones and process for the preparation and method of use thereof.
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