Freezing and thawing bag, mold, apparatus and method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B29C-043/02
C12M-001/24
출원번호
US-0672074
(2000-09-28)
발명자
/ 주소
Coelho, Philip Henry
Rubinstein, Pablo
출원인 / 주소
ThermoGenesis Corp.
대리인 / 주소
Bernhard Kreten, Esq. & Associates
인용정보
피인용 횟수 :
37인용 특허 :
82
초록▼
A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the const
A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed with their larger planar surfaces in contact with each other.
대표청구항▼
1. A method for forming a bag, the steps including:forming a first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to sai
1. A method for forming a bag, the steps including:forming a first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface, whereby a portal formed by said portal-shaped recess passes into an interior of the bag,placing a blank of sheet material over said first mold, and causing the blank to conform to the mold and retain its conformation, whereby a conformed sheet includes a recess that includes a planar surface, radiused periphery and peripheral ledge,removing the conformed sheet from the mold,closing the recess formed in the conformed sheet with another sheet parallel to the planar surface andcontaining within said bag thermolabile substances;forming a portal in the mold and bag and sealing at the portal the thermolabile substances in the bag; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 2. A method for forming a medical bag which is resistant to forces engendered by medical fluid undergoing a phase change within the bag, the steps including:forming a first mold having a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface,placing a blank of sheet material over said mold, and causing the blank to conform to the mold and retain its conformation, including a planar surface, radiused periphery and peripheral ledge,removing the conformed sheet from the mold,closing the recess formed in the sheet with another sheet parallel to the planar surface such that the radiused periphery dissipates forces during phase change;forming at least one closeable portal in the bag; andfilling the bag with a thermolabile biological fluid and freezing the fluid in the bag. 3. A method for forming a bag, the steps including:forming a first mold having a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface,placing a blank of sheet material over said first mold and causing the blank to conform to the mold and retain its conformation, whereby a conformed sheet includes a recess that includes a planar surface, radiused periphery and peripheral ledge, the sheet material composed of a material having a shape memory, whereby a conformed sheet retains a conformed shape after a conformation occurs, the conformed shape being flexible without brittleness or resistance to deformation,removing the conformed sheet from the mold, andclosing the recess formed in the conformed sheet with another sheet parallel to the planar surface; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 4. A method for forming a bag, the steps including:forming a first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface, whereby a portal formed by said portal-shaped recess passes into an interior of the bag,placing a blank of sheet material over said first mold, and causing the blank to conform to the mold and retain its conformation, whereby a conformed sheet includes a recess that includes a planar surface, radiused periphery and peripheral ledge, the sheet material composed of a material having a shape memory, whereby a conformed sheet retains a conformed shape which includes a planar surface, radiused periphery and peripheral ledge after a conformation occurs, the conformed shape being flexible without brittleness or resistance to deformation,removing the confor med sheet from the mold, andclosing the recess formed in the conformed sheet with another sheet parallel to the planar surface; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 5. A method for forming a medical bag from a material having a shape memory, the steps including:forming a first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface, whereby a portal formed by said portal-shaped recess passes into an interior of the bag,placing a blank of sheet material over said first mold, and causing the blank to conform to the mold and retain its conformation, whereby a conformed sheet includes a recess that includes a planar surface, radiused periphery and peripheral ledge, wherein the conformed sheet retains a conformed shape which includes a planar surface, radiused periphery and peripheral ledge after a conformation occurs, the conformed shape being flexible without brittleness or resistance to deformation,removing the conformed sheet from the mold, andclosing the recess formed in the conformed sheet with another sheet parallel to the planar surface; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 6. A method for forming a flexible, memory-retaining medical bag, the steps including:forming a first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface, whereby a portal formed by said portal-shaped recess passes into an interior of the bag,placing a blank of sheet material over said first mold, and causing the blank to conform to the mold and retain its conformation, whereby a conformed sheet includes a recess that includes a planar surface, radiused periphery and peripheral ledge, the sheet material including a shape memory, whereby a conformed sheet retains a conformed shape which includes a planar surface, radiused periphery and peripheral ledge after a conformation occurs, the conformed shape being flexible without brittleness or resistance to deformation,removing the conformed sheet from the mold, andclosing the recess formed in the conformed sheet with another sheet parallel to the planar surface; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 7. A method for forming a bag, the steps including:conforming a sheet material to a first mold, said first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface, whereby a portal formed by said portal-shaped recess passes into an interior of the bag, said material having a shape memory of a post-conformation shape,removing the conformed sheet from the mold, andclosing the recess formed in the conformed sheet with another sheet parallel to the planar surface; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 8. A method for forming a bag, the steps including:forming a first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface, whereby a portal formed by said portal-shaped recess passes into an interior of the bag,placing a blank of sheet material over said first mold, and causing the blank to conform to the mold an d retain its conformation, whereby a conformed sheet includes a recess that includes a planar surface, radiused periphery and peripheral ledge,removing the conformed sheet from the mold, andclosing the recess formed in the conformed sheet with another sheet parallel to the planar surface;containing within said bag thermolabile substances; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 9. A method for forming a bag, the steps including:forming a first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface, whereby a portal formed by said portal-shaped recess passes into an interior of the bag,placing a blank of sheet material over said first mold, and causing the blank to conform to the mold and retain its conformation, whereby a conformed sheet includes a recess that includes a planar surface, radiused periphery and peripheral ledge,removing the conformed sheet from the mold, andclosing the recess formed in the conformed sheet with another sheet parallel to the planar surface;containing within said bag cellular biological substances;forming a portal in the mold and the bag and sealing at the portal the cellular biological substances within the bag; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 10. A method for forming a bag, the steps including:forming a first mold having at least one portal-shaped recess and a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface, whereby a portal formed by said portal-shaped recess passes into an interior of the bag,placing a blank of sheet material over said first mold, and causing the blank to conform to the mold and retain its conformation, whereby a conformed sheet includes a recess that includes a planar surface, radiused periphery and peripheral ledge,removing the conformed sheet from the mold, andclosing the recess formed in the conformed sheet with another sheet parallel to the planar surface;wherein enclosing the bag is performed by forming a second mold having a mirror image of the first mold and placing a blank of sheet material over said second mold causing the blank to conform to the mold and forming the bag by registering the formed sheet from the first mold and formed sheet from the second mold together; andsubsequently freezing the bag whereby the radiused periphery of the bag dissipates forces due to freezing within the bag. 11. A method for forming a medical bag which is resistant to forces engendered by medical fluid undergoing a phase change within the bag, the steps including:forming a first mold having a recess including a planar surface, a radiused periphery circumscribing said planar surface and a peripheral ledge circumscribing said radiused periphery and oriented parallel to said planar surface,placing a blank of sheet material over said mold, and causing the blank to conform to the mold and retain its conformation, including a planar surface, radiused periphery and peripheral ledge,removing the conformed sheet from the mold, andclosing the recess formed in the sheet with another sheet parallel to the planar surface such that the radiused periphery dissipates forces during phase change, andfilling the bag with a thermolabile biological fluid and freezing the fluid in the bag.
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