초록 ▼

A nueroprotectant composition wherein the active ingredient is pGLU-GLU-PRO-NH 2 or a combination of pGLU-GLU-PRO-NH 2 (EEP) and N-tert-Butyl-α-(2-sulfophenyl)nitrone (SPBN) or other nitrone. A method of treating and preventing diseases and injuries of the brain, spinal cord and retina is al

A nueroprotectant composition wherein the active ingredient is pGLU-GLU-PRO-NH 2 or a combination of pGLU-GLU-PRO-NH 2 (EEP) and N-tert-Butyl-α-(2-sulfophenyl)nitrone (SPBN) or other nitrone. A method of treating and preventing diseases and injuries of the brain, spinal cord and retina is also presented by administering the endogenous tripeptide EEP to a subject as a neuroprotectant or by administering EEP in combination with SPBN or other nitrone.

대표청구항 ▼

1. A pharmaceutical composition comprising pGLU-GLU-PRO-NH 2 and one or more nitrones as active ingredients. 2. A pharmaceutical composition comprising pGLU-GLU-PRO-NH 2 and N-tert-Butyl-α-(2-sulfophenyl)nitrone as active ingredients. 3. A method of reducing Glu induced neurotoxicity in brai

1. A pharmaceutical composition comprising pGLU-GLU-PRO-NH 2 and one or more nitrones as active ingredients. 2. A pharmaceutical composition comprising pGLU-GLU-PRO-NH 2 and N-tert-Butyl-α-(2-sulfophenyl)nitrone as active ingredients. 3. A method of reducing Glu induced neurotoxicity in brain, spinal cord and/or retina comprising administering to a patent a composition comprising a therapeutically effective amount of pGLU-GLU-PRO-NH 2 as an active ingredient under time and conditions to treat said Glu induced neurotoxicity. 4. The method of claim 3, wherein said administering comprises administering to said patient the composition via oral, parenteral, intravenous, intramuscular, subcutaneous, transdermal, intrathecal, rectal or intranasal routes. 5. A method of reducing Glu induced neurotoxicity in brain, spinal cord and/or retina comprising administering to a patient a composition comprising a therapeutically effective amount of (a) pGLU-GLU-PRO-NH 2 and (b) N-tert-Butyl-α-2-sulfophenyl) nitrone or a free radical scavenging nitrone that enhances the effects of pGLU-GLU-PRO-NH 2 under time and conditions to treat said Glu induced neurotoxicity. 6. The method of claim 5, wherein said administering comprises administering to said patient the composition via oral, parenteral, intravenous, intramuscular, subcutaneous, transdermal, intrathecal, rectal or intranasal routes. 7. A method of protecting against Glu induced neurotoxicity in the brain, spinal cord and/or retina comprising administering to a patient a composition comprising a therapeutically effective amount of pGLU-GLU-PRO-NH 2 as an active ingredient under time and conditions to protect against said Glu induced neurotoxicity.