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A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium pho

A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.

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1. A method of applying coating having a therapeutic agent to an implant comprising:coating the implant with a layer of crystalline hydroxyapatite by precipitating the hydroxyapatite from solution;drying the coated implant;sterilizing the coated implant;packaging the coated implant;removing the impl

1. A method of applying coating having a therapeutic agent to an implant comprising:coating the implant with a layer of crystalline hydroxyapatite by precipitating the hydroxyapatite from solution;drying the coated implant;sterilizing the coated implant;packaging the coated implant;removing the implant from the package and then coating the implant with bone morphogenic protein solution; andthereafter implanting the implant coated with the bone morphogenic protein solution. 2. The method as set forth in claim 1 further including implanting the implant in its wetted state. 3. The method as set forth in claim 1 wherein the BMP is dissolved in a solution. 4. The method as set forth in claim 1 wherein the BMP is suspended in a solution. 5. The method as set forth in claim 1 wherein the implant is immersed in the bone morphogenic protein solution. 6. The method as set forth in claim 1 wherein the bone morphogenic protein solution is added to the dried coating drop wise. 7. The method as set forth in claim 1 wherein the hydroxyapatite coating comprises at least two layers. 8. A method for providing a bone morphogenic protein to an implant comprising:providing an implant having a dry coating of crystalline calcium phosphate minerals;packaging the implant;sterilizing the implant;removing the implant from the package;coating the crystalline calcium phosphate implant after removing it from the package with a bone morphogenic protein solution by adding the solution to the dried coating drop wise; andimmediately implanting the implant coated with the bone morphogenic solution. 9. The method as set forth in claim 8 wherein the bone morphogenic protein is dissolved in the solution. 10. The method as set forth in claim 8 wherein the bone morphogenic protein is suspended in the solution. 11. The method as set forth in claim 8 wherein the coating of crystalline calcium phosphate has more than one layer. 12. A method of applying a coating having bone morphogenic protein to an implant comprising:coating the implant with a layer of hydroxyapatite by precipitating the hydroxyapatite from solution;drying the coated implant;packaging the dried coated implant;sterilizing the packaged coated implant;removing the dried implant from the package;coating the dried hydroxyapatite coated implant with a solution of bone morphogenic protein; andimmediately implanting the implant after coating it with the bone morphogenic protein. 13. The method as set forth in claim 12 further including implanting the implant in its wetted state. 14. The method as set forth in claim 12 wherein the bone morphogenic protein is dissolved in the solution. 15. The method as set forth in claim 12 wherein the bone morphogenic protein is suspended in the solution. 16. The method as set forth in claim 12 wherein the implant is immersed in the bone morphogenic protein solution. 17. The method as set forth in claim 12 wherein the bone morphogenic protein solution is added to the dried coating drop wise. 18. The method as set forth in claim 12 wherein the hydroxyapatite coating comprises at least two layers.