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A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation is described. Warming the air of an aerosol makes it possible to reduce the size of aerosol particles produced by an aerosol generation device. Additionally, warming the air forces the si

A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation is described. Warming the air of an aerosol makes it possible to reduce the size of aerosol particles produced by an aerosol generation device. Additionally, warming the air forces the size of the aerosol particles to be in the range required for systemic drug delivery independent of ambient conditions. Smaller particles can be more precisely targeted to different areas of the respiratory tract.

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1. A method, comprising:aerosolizing a liquid formulation comprised of a pharmaceutically active drug; supplying the current from a battery having a physical sign equivalent to or smaller than two standard D size electric cells; heating the aerosol by application of the current from the battery to a

1. A method, comprising:aerosolizing a liquid formulation comprised of a pharmaceutically active drug; supplying the current from a battery having a physical sign equivalent to or smaller than two standard D size electric cells; heating the aerosol by application of the current from the battery to a wire coil comprising copper and a metal chosen from chromium and iron, the wire having a total heat capacity of about 0.2 to 4.35 J/° C. and a gauge in a range of from about 16 to about 36 and weighting from about 0.5 gram to about 10 grams and having a surface area of about 10 cm2. 2. The method of claim 1, further comprising:drawing the aerosol through a channel comprising an air flow path and an opening into which air is inhaled. 3. The method of claim 2, further comprising:sensing ambient conditions and adjusting current supplied based on sensed ambient conditions. 4. A drug delivery device, comprising:a channel comprising an air flow path, a first opening into which air can be inhaled and a second opening comprising a mouthpiece from air can be drawn; a heating element comprising a wire coil with a total heat capacity of about 0.2 to 4.35 J/° C. and having a mass of about 0.5 gram to about 10 grams and a surface area of about 10cm2 to about 150 cm2, and a resistance in a range of from about 0.5 ohm to about 5 ohms the heating element positioned in the flow path of the channel. 5. The device of claim 4, wherein the heating element has a mass of about 2 to 4 grams.6. The device of claim 4, further comprising:a portable source of power capable of supplying sufficient power to the heating element, over a period of less than or equal to one minute to enable the heating element to deliver about 150 to 350 Watts of energy to surrounding air in about 0.5 to 4.0 seconds. 7. The device of claim 6, where the portable power source comprises a battery capable of supplying a voltage within the range of about 1 to 20 Volts.8. The device of claim 4, wherein the heating element is configured to deliver about 150 to 350 Watts of energy to surrounding air in about 0.5 to 4.0 seconds.9. The device of claim 8, wherein the heating element is configured to deliver about 250 Watts of energy to surrounding air in about 1 to 2 seconds.10. The device of claim 4, wherein the heating element comprises nickel chromium wire and has a mass of about 3 to 7 grams.11. The device of claim 10, wherein the heating element has a mass about 5 grams.12. The device of claim 4, wherein the heating element is capable of generating at least 20 joules of heat energy when connected with a portable power source over a period of less than or equal to one minute.