Cationic alkyd polyesters for medical applications
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
B32B-007/02
A61K-031/70
출원번호
US-0323367
(2002-12-19)
발명자
/ 주소
Nathan, Aruna
출원인 / 주소
Ethicon, Inc.
인용정보
피인용 횟수 :
23인용 특허 :
48
초록
The present invention is directed to medical devices or pharmaceutical composition, each containing a synthetic, biodegradable, biocompatible polymer that is the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.
대표청구항▼
1. A medical device, comprising: a synthetic, biodegradable, biocompatible polymer comprising the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.2. The medical device of claim 1 wherein said polybasic acid or derivative thereof is selected from the
1. A medical device, comprising: a synthetic, biodegradable, biocompatible polymer comprising the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.2. The medical device of claim 1 wherein said polybasic acid or derivative thereof is selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid, diglycolic anhydride, glutaric acid, glutaric anhydride, adipic acid, pimelic acid, suberic acid, sebacic acid, fumaric acid, maleic acid, maleic anhydride, mixed anhydrides, esters, activated esters and acid halides.3. The medical device of claim 1 wherein said monoglyceride is selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauroyl glycerol, monolinoleoyl glycerol and monoolcoyl glycerol.4. The medical device of claim 3 wherein said polybasic acid derivative is succinic anhydride.5. The medical device of claim 3 wherein said polybasic acid is succinic acid.6. The medical device of claim 1 wherein said cationic polyol is selected from the group consisting of N-methyl diethanolamine, and 3-dimethylamino-1,2 propanediol.7. The medical device of claim 1 wherein said polymer is branched.8. The medical device of claim 1 wherein said polymer comprises the reaction product of said monoglyceride, said cationic polyol, and at least two of said polybasic acids or derivatives thereof selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid and diglycolic anhydride.9. The medical device of claim 1 wherein said polymer comprises the reaction product of said polybasic acid or derivative thereof, said cationic polyol, and at least two monoglycerides selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauroyl glycerol, monolinoleoyl glycerol and monooleoyl glycerol.10. The medical device of claim 1 wherein said polymer comprises the reaction product of said monoglyceride, said polybasic acid or derivative thereof, N-methyl diethanolamine, and 3-dimethylamino-1,2 propanediol.11. The medical device of claim 1 further comprising an effective amount of a bioactive agent.12. The medical device of claim 1 further comprising end capping moieties selected from the group consisting of alkyls, alkenyls, alkynyls, acrylates, methacrylates, amines, isocyanates and isothiocyanates.13. The medical device of claim 1 further comprising an aliphatic polyester prepared from monomers selected from the group consisting of glycolide, L-lactide, D-lactide, meso-lactide, rac-lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, 1,4-dioxanone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and substituted derivatives thereof.14. The medical device of claim 1 comprising a coating of said polymer.15. The medical device of claim 14 further comprising an aliphatic polyester prepared from the group of monomers selected from the group consisting of glycolide, L-lactide, D-lactide, meso-lactide, rac-lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, 1,4-dioxanone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and substituted derivatives thereof.16. The medical device of claim 1 selected from the group consisting of sutures, stents, vascular grafts, stent-graft combinations, meshes, tissue engineering scaffolds, pins, clips, staples, films, sheets, foams, anchors, screws and plates.17. The device of claim 1 wherein said polymer is a polymeric wax having a melting point between about 25° C. and about 70° C.18. The device of claim 1 wherein said polymer is a liquid polymer having a melting point below about 25° C.19. A composition, comprising: an effective amount of a bioactive agent, and a polymer comprising the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.20. The composition of claim 19 wherein said polybasic acid or derivative thereof is selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid, diglycolic anhydride, glutaric acid, glutaric anhydride, adipic acid, pimelic acid, suberic acid, sebacic acid and derivatives thereof.21. The composition of claim 19 wherein said monoglyceride is selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl, monolauroyl glycerol, monolinoleoyl glycerol and monooleoyl glycerol.22. The composition of claim 21 wherein said polybasic acid derivative is succinic anhydride.23. The composition of claim 21 wherein said polybasic acid is succinic acid.24. The composition of claim 19 wherein said polymer is branched.25. The composition of claim 19 wherein said copolymer comprises the reaction product of said monoglyceride, said cationic polyol, and at least two of said polybasic acids or derivatives thereof selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid and diglycolic anhydride.26. The composition of claim 19 wherein said copolymer comprises the reaction product of said polybasic acid or derivative thereof, said cationic polyol, and at least two monoglycerides selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauroyl glycerol, monolinoleoyl glycerol and monooleoyl glycerol.27. The composition of claim 19 wherein said copolymer comprises the reaction product of said monoglyceride, said polybasic acid or derivative thereof, N-methyl diethanolamine, and 3-dimethylamino-1,2 propanediol.28. The composition of claim 19 wherein said bioactive agent is selected from the group consisting of antiinfectives, analgesics, anorexics, antihelmintics, antiarthritics, antiasthmatics, anticonvulsants, antidepressants, antidiuretics, antidiarrheals, antihistamines, antiinflammatory agents, antimigraine preparations, antinauseants, antineoplastics, antiparkinsonism drugs, antipruritics, antipsychotics, antipyretics, antispasmodics, anticholinergics, sympathomimetics, xanthine derivatives, calcium channel blockers, beta-blockers, antiarrhythmics, antihypertensives, diuretics, vasodilators, central nervous system stimulants, decongestants, hormones, steroids, hypnotics, immunosuppressives, muscle relaxants, parasympatholytics, psychostimulants, sedatives, tranquilizers, naturally derived or genetically engineered proteins, growth factors, polysaccharides, glycoproteins, or lipoproteins, oligonucleotides, antibodies, antigens, cholinergics, chemotherapeutics, hemostatics, clot dissolving agents, radioactive agents and cystostatics.29. The composition of claim 19 further comprising an aliphatic polyester prepared from the group of monomers selected from the group consisting of glycolide, L-lactide, D-lactide, meso-lactide, rac-lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, 1,4-dioxanone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and substituted derivatives thereof.30. The composition of claim 19 wherein said polymer is a polymeric wax having a melting point between about 25° C. and about 70° C.31. The composition of claim 19 wherein said polymer is a liquid polymer having a melting point below about 25° C.32. A microdispersion comprising: a blend of a polymeric wax and a liquid polymer, wherein said polymeric wax and said liquid polymer comprise the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.33. The microdispersion of claim 32 wherein said polybasic acid or derivative thereof is selected from the group consisting of succinic acid, succinic anhydride, malic acid, tantaric acid, citric acid, diglycolic acid, diglycolic anhydride, glutaric acid, glutaric anhydride, adipic acid, pimelic acid, suberic acid, sebacic acid, fumaric acid, maleic acid, maleic anhydride, mixed anhydrides, esters, activated esters and acid halides.34. The microdispersion of claim 32 wherein said monoglyceride is selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauroyl glycerol, monolinoleoyl glycerol and monooleoyl glycerol.35. The microdispersion of claim 34 wherein said polybasic acid derivative is succinic anhydride.36. The microdispersion of claim 34 wherein said polybasic acid is succinic acid.37. The microdispersion of claim 34 wherein said cationic is selected from the group consisting of N-methyl diethanolamine, and 3-dimethylamino-1,2 propanediol.38. The microdispersion of claim 32 further comprising an effective amount of a bioactive agent.
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