Dry powders of metal-containing compounds are disclosed. Methods of preparing and using the dry powders, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti
Dry powders of metal-containing compounds are disclosed. Methods of preparing and using the dry powders, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
대표청구항▼
1. A method of treating a human or animal subject having a condition, the method comprising:contacting an area of the subject having the condition with an antimicrobial nanocrystalline metal-containing compound by dry inhaling a safe and therapeutically effective amount of a free-standing powder of
1. A method of treating a human or animal subject having a condition, the method comprising:contacting an area of the subject having the condition with an antimicrobial nanocrystalline metal-containing compound by dry inhaling a safe and therapeutically effective amount of a free-standing powder of the antimicrobial nanocrystalline metal-containing compound, wherein: the condition is selected from the group consisting of bacterial respiratory conditions, microbial respiratory conditions, fungal respiratory conditions and viral respiratory conditions, the antimicrobial nanocrystalline metal-containing compound contains a metal selected from the group consisting of silver, gold, platinum and palladium, and the free-standing powder of the antimicrobial nanocrystalline metal-containing compound has an average particle size of less than about two microns. 2. The method of claim 1, wherein the antimicrobial nanocrystalline metal-containing compound is selected from the group consisting of silver, gold, platinum, palladium, and alloys thereof.3. The method of claim 1, wherein the antimicrobial nanocrystalline metal-containing compound is an oxide, nitride, boride, halide or hydride of silver, gold, platinum or palladium.4. The method of claim 1, wherein the antimicrobial nanocrystalline metal-containing compound comprises silver.5. The method of claim 1, antimicrobial nanocrystalline metal-containing compound comprises an ionic compound of silver, gold, platinum or palladium.6. The method of claim 1, wherein the antimicrobial nanocrystalline metal-containing compound comprises atoms, molecules or clusters of silver, gold, platinum or palladium.7. The method of claim 1, wherein the antimicrobial nanocrystalline metal-containing compound comprises an atomically disordered, crystalline compound of silver, gold, platinum or palladium.8. The method of claim 1, wherein the condition is selected from the group consisting of bronchitis, tuberculosis, pneumonia, sinusitis, and pharyngitis.9. The method of claim 1, wherein the free-standing powder is inhaled with a dry powder inhaler.10. The method of claim 1, wherein the free-standing powder has an average particle size of about one micron or less.11. The method of claim 1, wherein the condition is a bacterial respiratory condition.12. The method of claim 1, wherein the condition is a microbial respiratory condition.13. The method of claim 1, wherein the condition is a fungal respiratory condition.14. The method of claim 1, wherein the condition is a viral respiratory condition.15. The method of claim 1, wherein the condition is bronchitis.16. The method of claim 1, wherein the condition is tuberculosis.17. The method of claim 1, wherein the condition is pneumonia.18. The method of claim 1, wherein the condition is sinusitis.19. The method of claim 1, wherein the condition is pharyngitis.20. The method of claim 1, wherein the condition is pneumonia and the antimicrobial nanocrystalline metal-containing compound comprises silver.
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