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The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels

The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

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1. A method for screening catalysts for a reaction of interest, the method comprisingfeeding one or more reactants through one or more distribution valves to six or more reaction vessels, the one or more reactants being fed simultaneously to at least two of the reaction vessels, each of the six or m

1. A method for screening catalysts for a reaction of interest, the method comprisingfeeding one or more reactants through one or more distribution valves to six or more reaction vessels, the one or more reactants being fed simultaneously to at least two of the reaction vessels, each of the six or more vessels comprising an inlet in fluid communication with an entrance control volume, an outlet in fluid communication with an exit control volume, and a different candidate catalyst in the reaction vessel, the one or more distribution valves providing selective fluid communication between the entrance control volume and the six or more reaction vessels, contacting the six or more different candidate catalysts with the one or more reactants in the six or more reaction vessels under reaction conditions for the reaction of interest, at least two different candidate catalysts being contacted simultaneously with the one or more reactants in the at least two reaction vessels into which the one or more reactants are fed simultaneously, discharging reaction products and unreacted reactants, if any, from the six or more reaction vessels, through one or more selection valves to one or more detectors, the one or more selection valves providing selective fluid communication between the six or more reaction vessels and the one or more detectors, reaction products or unreacted reactants being discharged simultaneously from the at least two reaction vessels into which the one or more reactants are fed simultaneously, controlling the contact time to be about the same for each of the six or more candidate catalysts by synchronized operation of one or more distribution valves and the one or more selection valves, and detecting resulting reaction products or unreacted reactants to determine the efficacy of the six or more catalyst candidates, the resulting reaction products or unreacted reactants discharged simultaneously from the at least two vessels being detected simultaneously. 2. The method of claim 1 further comprising controlling the flowrate of the one or more reactants to be about the same in the six or more reaction vessels.3. The method of claim 1 further comprising controlling the flowrate of the one or more reactants to be about the same in the six or more reaction vessels by flowing the one or more reactants through six or more flow restrictors, each of six or more flow restrictors providing fluid communication between one of the six or more vessels and (i) the one or more distribution valves, or alternatively, (ii) the one or more selection valves.4. The method of claim 3 wherein the resistance to fluid flow within a given flow channel is greatest in the flow restrictor, and the resistance to flow in each of the six or more flow restrictors is approximately the same, such that maintaining a higher pressure in the entrance control volume than in the exit control volume results in fluid flow through the at least six vessels that is apportioned approximately equally between each of the at least six vessels.5. The method of claim 3 wherein each of the six or more flow restrictors provide fluid communication between one of the six or more reaction vessels and the one or more distribution valves.6. The method of claim 1 further comprising controlling the flowrate of the one or more reactants to be about the same in the six or more reaction vessels by flowing the one or more reactants through one or more flow regulators.7. A method for screening catalysts for a reaction of interest, the method comprisingsimultaneously feeding one or more reactants through six or more reaction vessels, each of the six or more vessels comprising an inlet in fluid communication with an entrance control volume, an outlet in fluid communication with an exit control volume, and a different candidate catalyst in the reaction vessel, simultaneously flowing the one or more reactants through six or more flow restrictors, each of the six or more flow restrictors providing fluid communication between one of the six or more vessels and the entrance control volume, the resistance to fluid flow being greatest and approximately the same in each of the six or more flow restrictors so that the flowrate of the one or more reactants through each of the six or more reaction vessels is approximately the same, contacting the six or more different candidate catalysts with the one or more reactants in the six or more reaction vessels under reaction conditions for the reaction of interest, and detecting the reaction products or unreacted reactants to determine the efficacy of the six or more catalyst candidates. 8. A method for screening members of a combinatorial library, the method comprisingsimultaneously flowing a test fluid through six or more vessels, each of the six or more vessels comprising a member of the combinatorial library, simultaneously flowing the test fluid through six or more flow restrictors, each of the six or more flow restrictors providing fluid communication between one of the six or more vessels and (i) an entrance control volume, or alternatively, (ii) an exit control volume, the resistance to fluid flow being greatest and approximately the same in each of the six or more flow restrictors so that the flowrate of the test fluid through each of the six or more vessels is approximately the same, simultaneously contacting at least six of the six or more library members with the test fluid in the six or more vessels, simultaneously detecting changes in the test fluid following contact with each of the six or more library members, and correlating the changes in the test fluid to a property of each of the six or more library members. 9. A method for screening catalysts for a reaction of interest, the method comprisingsimultaneously feeding one or more reactants through six or more reaction vessels, each of the six or more vessels comprising a different candidate catalyst, simultaneously flowing the one or more reactants through six or more flow restrictors, each of the six or more flow restrictors providing fluid communication between one of the six or more reaction vessels and (i) an entrance control volume, or alternatively, (ii) an exit control volume, the resistance to fluid flow being greatest and approximately the same in each of the six or more flow restrictors so that the flowrate of the one or more reactants through each of the six or more reaction vessels is approximately the same, simultaneously contacting the candidate catalysts with the one or more reactants in the six or more reaction vessels under reaction conditions for the reaction of interest, and simultaneously detecting resulting reaction products or unreacted reactants to determine the efficacy of the six or more catalyst candidates. 10. The method of claim 8 or 9 wherein each of the six or more flow restrictors provide fluid communication between one of the six or more reaction vessels and an entrance control volume.11. The method of claim 8 wherein the time from initial contact of a library member with the test fluid to detection of changes in the test fluid is approximately the same for each of the six or more library members.12. The method of claim 8 wherein the detecting step determines changes in the composition of the test fluid.13. The method of claim 8 wherein the detecting step determines changes in the composition of the test fluid using gas chromatography, mass spectrometry, visible spectrometry, ultraviolet spectrometry, ultraviolet spectrometry or infrared spectrometry.14. The method of claim 8 wherein the six or more library members are at least forty-eight library members.15. The method of claim 8 wherein the total time to screen the six or more library members is less than about six minutes.16. The method of claim 8 wherein the total time to screen the six or more library members is less than about three minutes.17. The method of claim 8 wherein the six or more library members are at least forty-eight library members and the total time to screen the at least forty-eight library members is less than about forty-eight minutes.18. The method of claim 8 wherein the six or more library members are at least forty-eight library members and the total time to screen the at least forty-eight library members is less than about twenty-four minutes.19. The method of claim 8 wherein the six or more library members are exposed to a uniform temperature or a temperature gradient during the test.20. The method of claim 8 wherein about the same amount of each of the six or more library members are present in the respective vessels.21. The method of claim 8 wherein the test fluid is a gaseous test fluid.22. The method of claim 8 wherein the test fluid is a liquid test fluid.23. The method of claim 8 wherein the library member is a solid.24. The method of claim 8 wherein the library member is a liquid.25. The method of claim 8 wherein the test fluid is a gaseous test fluid and the library member is a solid.26. The method of claim 8 wherein the test fluid is a gaseous test fluid and the library member is a liquid.27. A method for screening catalysts for a reaction of interest, the method comprisingsimultaneously feeding one or more reactants through six or more reaction vessels, each of the six or more vessels comprising a different candidate catalyst, simultaneously flowing the one or more reactants through six or more flow restrictors, the flow restrictors being capillary tubes or micromachined channels, each of the six or more flow restrictors providing fluid communication between one of the six or more reaction vessels and (i) an entrance control volume, or alternatively, (ii) an exit control volume, the resistance to fluid flow being greatest and approximately the same in each of the six or more flow restrictors so that the flowrate of the one or more reactants through each of the six or more reaction vessels is approximately the same, contacting the candidate catalysts with the one or more reactants in the six or more reaction vessels under reaction conditions for the reaction of interest, and detecting resulting reaction products or unreacted reactants to determine the efficacy of the six or more catalyst candidates. 28. The method of claim 7 or 27 further comprisingdischarging reaction products and unreacted reactants, if any, from the six or more reaction vessels, and sampling the discharged reaction products or unreacted reactants with a sampling probe, the sampling probe being in fluid communication with one or more detectors. 29. The method of claim 9, 7 or 27 wherein the time from initial contact of a catalyst with the one or more reactants to detection of the reaction products or unreacted reactants is approximately the same for each of the six or more catalysts.30. The method of claim 9, 7 or 27 wherein the detecting step determines the reaction products or unreacted reactants using gas chromatography, mass spectrometry, visible spectrometry, ultraviolet spectrometry, ultraviolet spectrometry or infrared spectrometry.31. The method of claim 9, 7 or 27 wherein the six or more catalysts are exposed to a uniform temperature or a temperature gradient.32. The method of claim 9, 7 or 27 wherein the six or more catalysts are confined in the reaction vessels in the form of fixed beds.33. The method of claim 7 or 27 wherein the fluid handling system comprisesa selection valve providing selective fluid communication between a selected vessel and the detector, such that the reaction products or unreacted reactants can be sequentially directed from the selected vessel to the detector, and a fluid distribution valve providing selective fluid communication between the entrance control volume and the inlet of a selected vessel, such that the one or more reactants can be directed into the selected vessel, the method further comprising synchronizing the fluid distribution valve and the selection valve such that a time interval between the initial contact of the one or more reactants with one of the six or more catalysts and detection of reaction products or unreacted reactants is approximately the same for each of the six or more catalysts.