초록 ▼

Methods for preserving ophthalmic compositions are disclosed. In one embodiment, such compositions include a liquid medium and an antimicrobial component which is preferably substantially non-oxidative. Compositions which include a liquid medium and antimicrobial peptide magainins, present in an amo

Methods for preserving ophthalmic compositions are disclosed. In one embodiment, such compositions include a liquid medium and an antimicrobial component which is preferably substantially non-oxidative. Compositions which include a liquid medium and antimicrobial peptide magainins, present in an amount effective as a preservative, are also disclosed. Preserved compositions useful for administering a therapeutic component to the eyes or caring for contact lenses are also included within the scope of the present invention.

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1. An ophthalmic composition comprising a carrier component, and a preservative component selected from the group consisting of magainin antimicrobial peptides, analogs of magainin antimicrobial peptides and mixtures thereof present in an amount effective as a preservative in said composition, where

1. An ophthalmic composition comprising a carrier component, and a preservative component selected from the group consisting of magainin antimicrobial peptides, analogs of magainin antimicrobial peptides and mixtures thereof present in an amount effective as a preservative in said composition, wherein said composition is an oil-containing emulsion or an oil-containing suspension.2. The composition of claim 1 wherein said preservative component is present in an effective amount less than about 10 milligrams per milliliter.3. The composition of claim 1 which further comprises an effective amount of a buffer component to provide said composition with a desired pH.4. The composition of claim 1 which further comprises an effective amount of a tonicity component to provide said composition with a desired osmolality.5. The composition of claim 1 wherein said preservative component is a magainin antimicrobial peptide.6. The composition of claim 1 wherein said preservative component is an analog of a magainin antimicrobial peptide comprising the amino acid sequence of SEQ ID NO: 4.7. An ophthalmic composition comprising a carrier component, said composition further comprising an antimicrobial peptide mimetic present in an amount effective as a preservative in said composition, wherein said composition is an oil-containing emulsion or an oil-containing suspension.8. The composition of claim 7 wherein said antimicrobial peptide mimetic is present in an effective amount less than about 10 milligrams per milliliter.9. The composition of claim 7 which further comprises water and an effective amount of a buffer component to provide said composition with a desired pH.10. The composition of claim 7 which further comprises an effective amount of a tonicity component to provide said composition with a desired osmolality.11. The composition of claim 7 wherein said composition further includes a therapeutically effective component.12. A method of preserving an ophthalmic composition comprising:contacting an ophthalmic composition with a magainin analog with an amino acid sequence comprising of SEQ ID NO: 4 in an amount effective as a preservative in said composition, wherein said composition is an oil-containing emulsion or an oil-containing suspension. 13. An ophthalmic composition comprising a magainin antimicrobial analog with an amino acid sequence comprising of SEQ ID NO: 4 present in an amount effective as a preservative in said composition, wherein said composition is provided in a multidose format and wherein said composition is an oil-containing emulsion or an oil-containing suspension.14. The composition of claim 1, further comprising an effective amount of a therapeutically effective component.15. The composition of claim 14, wherein the therapeutically effective component comprises an antibiotic.16. The composition of claim 15, wherein the antibiotic is cyclosporin.17. The composition of claim 14, wherein the therapeutically effective component comprises a steroid.18. The composition of claim 17, wherein the steroid is prednisolone acetate.19. The composition of claim 1, wherein the preservative component is the sole preservative in said composition.20. The composition of claim 1, wherein the composition is a surgical irrigant.21. The composition of claim 1, further comprising a second antimicrobial component.22. The composition of claim 21, wherein the second antimicrobial component is a substantially non-oxidative antimicrobial component.