Automated system adaptable for use with different fluid circuits
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-037/00
C02F-001/44
출원번호
US-0800206
(2001-03-06)
발명자
/ 주소
Brown, Richard I.
Min, Kyungyoon
Vishnoi, Rohit
Thom, Sandra
Farrell, Liam
Westberg, Tom
출원인 / 주소
Baxter International Inc.
인용정보
피인용 횟수 :
18인용 특허 :
86
초록▼
Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit selected from one of two or more circuits. The circuits are mounted on a re-usable hardware component or module. The system includes a programmable controller
Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit selected from one of two or more circuits. The circuits are mounted on a re-usable hardware component or module. The system includes a programmable controller including programs for use with the fluid circuits.
대표청구항▼
1. An automated system for processing fluids from a human subject comprising a reusable module adapted to cooperatively receive a disposable fluid circuit for carrying out a selected procedure, including:(a) said reusable module including: (1) means for effecting separation of whole blood into two o
1. An automated system for processing fluids from a human subject comprising a reusable module adapted to cooperatively receive a disposable fluid circuit for carrying out a selected procedure, including:(a) said reusable module including: (1) means for effecting separation of whole blood into two or more components; and (2) a programmable controller and a computer readable medium including preprogrammed instructions for: (i) carrying out a procedure comprising withdrawing whole blood from the vascular system of said human subject, separating said whole blood into two or more components, collecting a separated blood component having at least one known biological function, determining the amount of replacement fluid capable of providing said biological function to be infused to said subject, reinfusing said replacement fluid to said subject, and (ii) carrying out a procedure comprising withdrawing extra-vascular, shed blood from said human subject, separating said blood into two or more components, infusing a separated blood component to said subject; (b) said disposable fluid circuit comprising a flow control cassette having pre-formed flow path segments therein separated by valve stations for controlling fluid communication between said flow path segments. 2. The system of claim 1 wherein said fluid circuit comprises means for accessing the vascular system of a human subject.3. The system of claim 1 wherein said fluid circuit comprises suction means for withdrawing whole blood from a human subject during a surgical procedure.4. The system of claim 1 including means for determining an effective amount of a first replacement fluid to be administered to said subject based at least in part on the amount of said collected fraction, said first replacement fluid being capable of substantially providing said biological function.5. The system of claim 1 comprising a portable case for housing said re-usable module.6. The system of claim 1 wherein said replacement fluid comprises an intravenous oxygen carrier.7. The system of claim 1 wherein said replacement fluid comprises a solution selected from the group consisting of a crystalline, colloidal or albumin solution.8. The system of claim 7 wherein said replacement fluid comprises saline.9. The system of claim 1 wherein said controller directs the delivery of an effective amount of said replacement fluid to be administered to said subject based at least in part on at least one of the amount of said collected blood components, or on the amount of whole blood withdrawn, or on subject information.10. The system of claim 9 wherein said replacement fluid comprises saline.11. The system of claim 1 wherein said fluid circuit comprises a separation chamber wherein said blood is separated into said components.12. The system of claim 1 wherein said replacement fluid comprises dextran.13. The system of claim 1 wherein said fluid circuit further comprises a solution for contacting said extra-vascular blood.14. An automated system for processing fluids from a human subject comprising a reusable module adapted to cooperatively receive a disposable fluid circuit for carrying out a selected procedure,(a) said re-usable module including: (1) means for effecting separation of whole blood into two or more components; and (2) a programmable controller and a computer readable medium including preprogrammed instructions for: (i) carrying out a procedure comprising withdrawing whole blood from the vascular system of said human subject, separating said whole blood into two or more components, collecting a separated blood component having at least one known biological function, determining the amount of replacement fluid capable of providing said biological function to be infused to said subject, reinfusing a replacement fluid to the human subject, wherein said replacement fluid provides said biological function; and (ii) carrying out a procedure comprising withdrawing whole blood from the vascular system of said subject, separating said blood into two or more components, determining the amount of a treating agent to be combined with a separated component, combining at least one of said separated components with a treating agent; (b) said disposable fluid circuit comprising a flow control cassette having pre-formed flow path segments therein separated by valve stations for controlling fluid communication between said flow path segments. 15. The system of claim 14 wherein said replacement fluid comprises an intravenous oxygen carrier.16. The system of claim 14 wherein said replacement fluid comprises a solution selected from the group consisting of a crystalline, colloidal or albumin solution.17. The system of claim 14 wherein said replacement fluid comprises saline.18. The system of claim 14 wherein said controller directs the delivery of an effective amount of said replacement fluid to be administered to said subject based at least in part on at least one of the amount of said collected blood components, or on the amount of whole blood withdrawn, or on subject information.19. The system of claim 18 wherein said replacement fluid comprises saline.20. The system of claim 14 wherein said fluid circuit comprises a separation chamber wherein said blood is separated into said components.21. The system of claim 14 wherein said replacement fluid comprises dextran.22. The system of claim 14 wherein said treating agent comprises a solvent for extracting lipids from at least said blood portion.23. The system of claim 14 wherein said second fluid circuit comprises means for returning at least one of said components to said patient.24. The system of claim 14 wherein said treating agent comprises an enzyme for converting red blood cells from a first type selected from the group consisting of A, B or AB to an O-type.25. An automated system for processing fluids from a human subject comprising a reusable module adapted to cooperatively receive a disposable fluid circuit for carrying out a selected procedure,(a) said reusable module including: (1) means for effecting separation of whole blood into two or more components; and (2) a programmable controller and a computer readable medium including preprogrammed instructions for: (i) carrying out a procedure comprising withdrawing extra-vascular, shed blood from said human subject, separating said blood into two or more components, infusing a separated blood component to said subject; and (ii) carrying out a procedure comprising withdrawing whole blood from the vascular system of said subject, separating said blood into two or more components, determining the amount of a treating agent to be combined with a separated component, combining at least one of said separated components with a treating agent; (b) said disposable fluid circuit comprising a flow control cassette having pre-formed flow path segments therein separated by valve stations for controlling fluid communication between said flow path segments. 26. The system of claim 25 wherein said treating agent comprises a solvent for extracting lipids from at least said blood portions.27. The system of claim 25 wherein said treating agent comprises an enzyme for converting red blood cells from a first type selected from the group consisting of A, B or AB to an O-type.28. The system of claim 25 wherein said fluid circuit further comprises a solution for contacting said extra-vascular, shed blood.29. An automated system for processing fluids from a human subject comprising a reusable module adapted to cooperatively receive a disposable fluid circuit for carrying out a selected procedure,(a) said re-usable module including: (1) means for effecting separation of whole blood into two or more components; and (2) a programmable controller and a computer readable medium including preprogrammed instructions for: (i) carrying out a procedure comprising withdrawing whole blood from the vascular system of said human subject, separating said whole blood into two or more components, collecting a separated blood component having at least one known biological function, determining the amount of replacement fluid capable of providing said biological function to be infused to said subject, reinfusing a replacement fluid to the subject, (ii) carrying out a procedure comprising withdrawing extra-vascular, shed blood from said human subject, separating said blood into two or more components, infusing a separated blood component to said subject; and (iii) carrying out a procedure comprising withdrawing whole blood from the vascular system of said subject, separating said blood into two or more components, determining the amount of a treating agent to be combined with a separated component, combining at least one of said separated components with a treating agent; (b) said disposable fluid circuit comprising a flow control cassette having pre-formed flow path segments therein separated by valve stations for controlling fluid communication between said flow path segments. 30. The system of claim 29 wherein said treating agent comprises a solvent adapted for extracting a selected compound from said blood.31. The system of claim 29 wherein said treating agent comprises an enzyme for converting red blood cells from a first type selected from the group consisting of A, B or AB to an O-type.32. The system of claim 29 wherein said flow control cassette further comprises pump stations for pumping fluid through said flow path segments.33. The system of claim 29 wherein said replacement fluid comprises an intravenous oxygen carrier.34. The system of claim 29 wherein said replacement fluid comprises a solution selected from the group consisting of a crystalline, colloidal or albumin solution.35. The system of claim 34 wherein said solution comprises saline.36. The system of claim 29 wherein said replacement fluid comprises saline.37. The system of claim 29 wherein said controller directs the delivery of an effective amount of said replacement fluid to be administered to said subject based at least in part on at least one of the amount of said collected blood components, or on the amount of whole blood withdrawn, or on subject information.38. The system of claim 29 wherein said fluid circuit comprises a separation chamber wherein said blood is separated into said components.39. The system of claim 29 wherein said replacement fluid comprises dextran.
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