Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-008/00
A61B-005/055
A61K-051/00
출원번호
US-0573265
(2000-05-18)
발명자
/ 주소
Unger, Evan C.
출원인 / 주소
Bristol-Myers Squibb Pharma Company
대리인 / 주소
Woodcock Washburn LLP
인용정보
피인용 횟수 :
19인용 특허 :
260
초록▼
Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous
Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combination with a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.
대표청구항▼
1. A method for diagnosing the presence of a disease of the coronary arteries in a patient comprising (i) administering to the patient by continuous intravenous infusion a vesicle composition comprising, in an aqueous carrier, vesicles and a gas or gaseous precursor, wherein said vesicles are select
1. A method for diagnosing the presence of a disease of the coronary arteries in a patient comprising (i) administering to the patient by continuous intravenous infusion a vesicle composition comprising, in an aqueous carrier, vesicles and a gas or gaseous precursor, wherein said vesicles are selected from the group consisting of liposomes and micelles, and comprise a phospholipid selected from the group consisting of dioleoylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine, dioleoylphosphatidylethanolamine, N-succinyldioleoylphosphatidylethanolamine, 1-hexadecyl-2-palmitoylglycerophosphoethanolamine, and phosphatidic acids, (ii) scanning the patient using diagnostic imaging to obtain a visible image of the myocardium, (iii) administering to the patient a coronary vasodilator, (iv) continuing said scanning, and (v) evaluating the degree of myocardial perfusion from a videodensity versus time relationship in the images obtained in steps (ii) through (iv), wherein said vesicle composition is administered for a time period of at least about 30 seconds or longer to maintain the concentration of vesicles in the cardiovascular region at about a constant level, said constant level being of sufficient time to provide a measurement of a baseline videodensitometry.2. A method according to claim 1 wherein said vesicles comprise unilamellar vesicles.3. A method according to claim 2 wherein said vesicles comprise one monolayer.4. A method according to claim 1 wherein said vesicles comprise one bilayer.5. A method according to claim 1 wherein said vesicles are selected from the group consisting of oligolamellar and multilamellar vesicles.6. A method according to claim 1 wherein said phosphatidic acid comprises dipalmitolylphosphatidic acid.7. A method according to claim 1 wherein said lipid further comprises a polymer.8. A method according to claim 7 wherein said polymer comprises a hydrophilic polymer.9. A method according to claim 8 wherein said hydrophilic polymer comprises polyethylene glycol.10. A method according to claim 1 wherein said gas comprises a fluorinated gas.11. A method according to claim 10 wherein said fluorinated gas is selected from the group consisting of a perfluorocarbon, sulfur hexafluoride and heptafluoropropane.12. A method according to claim 11 wherein said fluorinated gas comprises a perfluorocarbon.13. A method according to claim 12 wherein said perfluorocarbon gas is selected from the group consisting of perfluoromethane, perfluoroethane, perfluoropropane, perfluorobutane and perfluorocyclobutane.14. A method according to claim 1 wherein said diagnostic imaging is selected from the group consisting of ultrasound imaging and computed tomography imaging.15. A method according to claim 14 wherein said diagnostic imaging comprises ultrasound imaging.16. A method according to claim 1 wherein said coronary vasodilator is selected from the group consisting of arterial vasodilators, venous vasodilators, preload reducers and preload/afterload reducers.17. A method according to claim 16 wherein said coronary vasodilator is selected from the group consisting of nitroprusside, nitroglycerin, isosorbide dinitrate, isosorbide tetranitrate, nifedipine and dipyridamole.18. A method according to claim 17 wherein said coronary vasodilator is dipyridamole.19. A method according to claim 1 wherein said coronary vasodilator enhances brightness in the diagnostic image.20. A method according to claim 1 wherein said coronary vasodilator substantially eliminates diagnostic artifacts in the diagnostic image.21. A method according to claim 1 wherein said vesicle composition further comprises an additional bioactive agent.22. A method according to claim 1 wherein said step of administering said vesicular composition by continuous infusion comprises the use of a constant infusion device.23. A method according to claim 22 wherein said constant infusion device comprises a power injector.24. A method for evaluating coronary reserve in a patient comprising (i) administering to the patient by continuous intravenous infusion a vesicle composition comprising, in an aqueous carrier, vesicles and a gas or gaseous precursor, wherein said vesicles are selected from the group consisting of liposomes and micelles, and comprise a phospholipid selected from the group consisting of dioleoylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine, dioleoylphosphatidylethanolamine, N-succinyldioleoylphosphatidylethanolamine, 1-hexadecyl-2-palmitoylglycerophosphoethanolamine, and phosphatidic acids, (ii) scanning the patient using diagnostic imaging to obtain a visible image of the myocardium, (iii) administering to the patient a coronary vasodilator, (iv) continuing said scanning, (v) evaluating the difference in myocardial perfusion from a videodensity versus time relationship in the images obtained in steps (ii) through (iv), wherein said vesicle composition is administered for a time period of at least about 30 seconds or longer to maintain the concentration of vesicles in the cardiovascular region at about a constant level, said constant level being of sufficient time to provide a measurement of a baseline videodensitometry.25. A method according to claim 24 wherein said vesicles comprise unilamellar vesicles.26. A method according to claim 25 wherein said vesicles comprise one monolayer.27. A method according to claim 25 wherein said vesicles comprise one bilayer.28. A method according to claim 24 wherein said vesicles are selected from the group consisting of oligolamellar and multilamellar vesicles.29. A method according to claim 24 wherein said phosphatidic acid comprises dipalmitolylphosphatidic acid.30. A method according to claim 24 wherein said lipid further comprises a polymer.31. A method according to claim 30 wherein said polymer comprises a hydrophilic polymer.32. A method according to claim 31 wherein said hydrophilic polymer comprises polyethylene glycol.33. A method according to claim 24 wherein said gas comprises a fluorinated gas.34. A method according to claim 33 wherein said fluorinated gas is selected from the group consisting of a perfluorocarbon, sulfur hexafluoride and heptafluoropropane.35. A method according to claim 34 wherein said fluorinated gas comprises a perfluorocarbon.36. A method according to claim 35 wherein said perfluorocarbon gas is selected from the group consisting of perfluoromethane, perfluoroethane, perfluoropropane, perfluorobutane and perfluorocyclobutane.37. A method according to claim 24 wherein said diagnostic imaging is selected from the group consisting of ultrasound imaging and computed tomography imaging.38. A method according to claim 37 wherein said diagnostic imaging comprises ultrasound imaging.39. A method according to claim 24 wherein said coronary vasodilator is selected from the group consisting of arterial vasodilators, venous vasodilators, preload reducers and preload/afterload reducers.40. A method according to claim 39 wherein said coronary vasodilator is selected from the group consisting of nitroprusside, nitroglycerin, isosorbide dinitrate, isosorbide tetranitrate, nifedipine and dipyridamole.41. A method according to claim 40 wherein said coronary vasodilator is dipyridamole.42. A method according to claim 24 wherein said coronary vasodilator enhances brightness in the diagnostic image.43. A method according to claim 24 wherein said coronary vasodilator substantially eliminates diagnostic artifacts in the diagnostic image.44. A method according to claim 24 wherein said vesicle composition further comprises an additional bioactive agent.45. A method according to claim 24 wherein said step of administering said vesicular composition by continuous infusion comprises the use of a constant infusion device.46. A method according to claim 45 wherein said constant infusion device comprises a power injector.
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이 특허에 인용된 특허 (260)
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