[미국특허]
Iodine/resin disinfectant and a procedure for the preparation thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/74
A61K-031/785
출원번호
US-0161102
(2002-05-31)
발명자
/ 주소
Messier, Pierre Jean
출원인 / 주소
Triosyn Holding Inc.
대리인 / 주소
Goodwin Procter LLP
인용정보
피인용 횟수 :
4인용 특허 :
45
초록▼
The present invention relates to iodine demand disinfectants. It relates in particular to a process for preparing a polyiodide-resin for use as an iodine demand disinfectant wherein a porous strong base anion exchange resin in a salt form, is contacted with a material capable of donating a member ab
The present invention relates to iodine demand disinfectants. It relates in particular to a process for preparing a polyiodide-resin for use as an iodine demand disinfectant wherein a porous strong base anion exchange resin in a salt form, is contacted with a material capable of donating a member absorbable by the resin so as to convert the resin to the polyiodide-resin. The adsorbable member is selected from the group comprising I2 and polyiodide ion having a valence of ?1. The process is characterized in that conversion of the anion exchange resin to the polyiodide-resin is effected at elevated temperature and elevated pressure, the elevated temperature being 100 degrees C. or higher, the elevated pressure being greater than atmospheric pressure. The present invention also relates to disinfectant substance comprising an iodine (impregnated) resin as produced by the above process.
대표청구항▼
1. A sterilisation dressing, for being applied to a lesion, said dressing comprisinga demand disinfectant component and a carrier component, said demand disinfectant component comprising of an iodinated anion exchange resin, said demand disinfectant component being held to said carrier component suc
1. A sterilisation dressing, for being applied to a lesion, said dressing comprisinga demand disinfectant component and a carrier component, said demand disinfectant component comprising of an iodinated anion exchange resin, said demand disinfectant component being held to said carrier component such that microorganisms are able to be brought into contact with said particles and be devitalized thereby, said carrier component is a polymer.2. A dressing as defined in claim 1 wherein said carrier component is flexible and has an outer surface and wherein particles of said demand disinfectant are fixed to at least a portion of said outer surface.3. A dressing as defined in claim 1 wherein said carrier component is flexible and comprises a porous cellular polymeric matrix, wherein said demand disinfectant is dispersed in said polymeric matrix.4. A dressing as defined in claim 1 wherein said iodinated anion exchange resin comprises an anion exchange resin component which represents from 25 to 90 percent by weight of the total weight of the iodinated resin.5. A dressing as defined in claim 1 wherein said iodinated anion exchange resin comprises an anion exchange resin component which represents from 45 to 65 percent by weight of the total weight of the iodinated resin.6. A dressing as defined in claim 1 wherein said iodinated strong base anion exchange resin is an iodinated anion exchange resin prepared in accordance with a process comprising a conversion step, the conversion step comprising contacting a porous anion exchange resin in a salt form with a sufficeint amount of an iodine-substance absorbable by the anion exchange resin such that the anion exchange resin absorbs said iodine-substance so as to convert the anion exchange resin to the demand disinfectant resin, said iodine-substance being selected from the group consisting of I2 and polyiodide ions having a valence of ?1, characterized in that for the conversion step of at least a portion of the absorbtion of iodine-substance is effected at elevated temperature and at elevated pressure, said elevated temperature being higher that 100° C., said elevated pressure being greater than atmospheric pressure.7. A dressing as defined in claim 1 wherein said iodinated anion exchange resin is an iodinated anion exchange resin prepared in accordance with a process comprising a conversion step, the conversion step comprising contacting a porous anion exchange resin in a salt form other than the iodide form I?, with a sufficient amount of an iodine-substance absorbable by the anion exchange resin such that the anion exchange resin absorbs said iodine substance so as to convert the anion exchange resin to the demand disinfectant resin, said iodine being selected from the group consisting of polyiodide ions having a valence of ?1, characterized in that said conversion step comprises an initial conversion stage followed by a second conversion stage, in that said initial conversion stage comprises contacting the anion exchange resin with the iodine-substance at a temperature of 100° C. or lower so as to obtain an intermediate composition, said intermediate composition comprising residual absorbable iodine-substance and an intermediate iodinated resin, and in that said second conversion stage comprises subjecting the intermediate composition to elevated temperature and elevated pressure, said elevated temperature is a temperature of 102° C. or higher, said elevated pressure is a pressure of from 2 psig to 35 psig and wherein said iodine-substance comprises triiodide ions of formula I3, and wherein said anion exchange resin is in the hydroxyl from OH?; wherein the anion exchange resin is contacted with a composition consisting of a mixture of KI, I2 and a minor amount of water, the mole ratio of KI to I2 initially being about 1.8. A dressing as defined in claim 3 wherein said iodinated anion exchange resin is a iodinated anion exchange resin prepared in accordance with a process comprising a conversion step, the conversion step comprising contacting a porous anion exchange resin in a salt form other than the iodide form I?, with a sufficient amount of an iodine-substance absorbable by the anion exchange resin such that the anion exchange resin absorbs said iodine substance so as to convert the anion exchange resin to the demand disinfectant resin, said iodine-substance being selected from the group consisting of polyiodide ions having a valence of ?1, characterized in that said conversion step comprises an initial conversion stage followed by a second conversion stage, in that said initial conversion stage comprises contacting the anion exchange resin with the iodine-substance at a temperature of 100° C. or lower so as to obtain an intermediate composition, said intermediate composition comprising residual absorbable iodine-substance and an intermediate iodinated resin, and in that said second conversion stage comprises subjecting the intermediate composition to elevated temperature and elevated pressure, said elevated temperature is a temperature of 102° C. or higher, said elevated pressure is a pressure of from 2 psig to 35 psig and wherein said iodine-substance comprises triiodide ions of formula I3?, and wherein said anion exchange resin is in the hydroxyl form OH?, wherein the anion exchange resin is contacted with a composition consisting of a mixture of KI, I2 and a minor amount of water, the mole ratio of KI to I2 initially being about 1.9. A sterilization dressing, for being applied to a lesion, said dressing comprising a disinfectant component and a carrier component, said disinfectant component comprising an iodinated resin, said carrier component being configured so as to bold onto said disinfectant component such that microorganisms are able to be brought into contact with said particles and be devitalised thereby, said carrier component is a polymer.10. A method for disinfecting a body fluid containing microorganisms, said method comprising contacting said body fluid with a demand disinfectant resin such that microorganisms therein contact said resin and are deactivated thereby, said disinfectant resin being an iodinated strong base anion exchange resin.11. A method for disinfecting a body fluid as defined in claim 10 wherein said iodinated strong base anion exchange resin comprises a strong base anion exchange resin component which represents from 25 to 90 percent by weight of the total weight of the iodinated resin.12. A method for disinfecting a body fluid as defined in claim 10 wherein said iodinated strong base anion exchange resin comprises a strong base anion exchange resin component which represents from 45 to 65 percent by weight of the total weight of the iodinated resin.
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