[특허]Filter apparatus and methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses

[미국특허] Filter apparatus and methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01L-011/00
출원번호	US-0269220 (2002-10-11)
발명자 / 주소	Ferguson, Gary William
출원인 / 주소	G6 Science Corp.
대리인 / 주소	Trexler, Bushnell, Giangiorgi, Blackstone &
인용정보	피인용 횟수 : 12 인용 특허 : 52

초록 ▼

The present invention is a filter apparatus with methods to capture a desired amount of material suspended in a liquid or gas for monolayer deposition, analysis or other uses. Novel filter devices are employed to capture material which may be used for the purification or enrichment of various sample constituents or captured material may be observed or analyzed. Alternatively, particulate material may be used as a transport mechanism for proteins or chemicals which in turn may be assessed or used. The filter device employs sensors to sense pressure and adjust, halt or otherwise control sample flow. The pressure sensor essentially monitors the flow rate of sample suspension through a filter, typically responding at a predetermined pressure associated with capture of a desired amount of material on the filter. A separate valve or valve integrated with pressure sensing provides a means to adjust sample flow. Typically, pressure is used to cause the sample suspension to flow through the filter, which is preferably a membrane filter for monolayer deposition. In some embodiments a novel syringe provides this pressure, functioning as a vacuum source. The filter apparatus may be further automated to process a plurality of samples, simultaneously.

대표청구항 ▼

1. An apparatus for capturing a desired quantity of material from a sample suspension, comprising:a body member having an inlet port and an outlet port forming a single pathway through said apparatus for flow of sample suspension; a filter housed in said body member in said pathway; means for creating a flow of sample suspension through said filter by negative pressure; a sensor to measure a pressure differential across said filter; a flow control element in said body member downstream of said filter and in mechanical communication with said sensor, whereby said sensor activates said flow control element to vent said single pathway when a desired amount of material has been captured by said filter, to stop said flow of said sample suspension through said apparatus; and means for removing said captured material for subsequent analysis. 2. The apparatus of claim 1, wherein said sensor and said flow control element are integrated.3. The apparatus of claim 2, wherein said sensor and said flow control element comprise at least one poppet valve.4. The apparatus of claim 3, wherein said at least one poppet valve is adjustable.5. The apparatus of claim 2, wherein said sensor and said flow control element comprise at least one pressure-sensitive check valve.6. The apparatus of claim 5, wherein said at least one pressure-sensitive check valve is adjustable.7. The apparatus of claim 1, further comprising a surface for receiving material captured on said filter.

이 특허에 인용된 특허 (52) 인용/피인용 타임라인 분석

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Barnard ; Jr. George B. (Newbury Park CA), Bypass valve with indicator.
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Grimes Michael (Hayling Island GB2), Cylindrical filters and their manufacture.
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Kelley Thomas F. (Canton MA) Floyd Alton D. (Edwardsburg MD), Cytology centrifuge apparatus.
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Kelley Thomas F. (Canton MA) Petithory Henry A. (Southborough MA) Soares Todd W. (Milford MA), Cytology centrifuge apparatus.
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Powell Walter W. (13911 Emerald Forest Sugarland TX 77478), Direct spring pressure operated valve.
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Alchas Paul G. (Wayne NJ) Augello Frank A. (Cedar Knolls NJ) Brooks Christopher J. (Glen Cove NY) Cutshall Tony A. (Boonton NJ) DiPisa ; Jr. Joseph A. (Wyckoff NJ) Williams Stuart K. (Wilmington DE) , Endothelial cell procurement and deposition kit.
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Guirguis Raouf A. (Rockville MD), Environmental sample collection and membrane testing device.
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Vincent Monty E. (Ann Arbor MI) Vizulis Karlis (Ann Arbor MI), Filter with initially flat membrane and curved membrane support.
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Pope ; Jr. J. Lee (Baltimore MD) Scott James W. (Lindenhurst IL), Flexible membrane filter assembly.
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Zias Arthur R. (Los Altos CA) Block Barry (Los Altos Hills CA) Mapes Kenneth W. (San Jose CA) Nystrom Norman L. (Sunnyvale CA) Cadwell Robert M. (Los Altos CA), High sensitivity miniature pressure transducer.
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Clapham William Stephen,GB2 ; Warren John Joseph,GB2, Hydraulic circuit.
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Guirguis Raouf A., Liquid specimen container and attachable testing modules.
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Guirguis Raouf A., Liquid specimen container and attachable testing modules.
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Guirguis Raouf A. (Rockville MD), Liquid specimen container and attachable testing modules.
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Klein Vernon W. (Kansas City MO), Manual vacuum filtration device.
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Hermann Manfred P. (Numberg DEX) Bonn Heinz (Numberg DEX), Membrane filter plate.
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Klinkau Werner (Berg am Starnbergersee DEX) Stanik Reinmund (Marktoberdorf DEX), Membrane filter plate having improved bending characteristics of the membrane.
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James V. Bacus ; James W. Bacus, Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope.
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Douglass James W. ; Riding Thomas J. ; Ring James E., Method and apparatus for automated image analysis of biological specimens.
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Guirguis Raouf A., Method and apparatus for automatically separating particulate matter from a fluid.
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Gordon Julian, Method and apparatus for collecting a cell sample from a liquid specimen.
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Lapidus Stanley N., Method and apparatus for controlled instrumentation of particles with a filter device.
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Lapidus Stanley N., Method and apparatus for controlled instrumentation of particles with a filter device.
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Alex Urich ; Michael Curtis, Method and apparatus for controlling vacuum as a function of ultrasonic power in an ophthalmic phaco aspirator.
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Guirguis Raouf A. (11836 Dinwiddie Dr. Rockville MD 20852), Method and apparatus for obtaining a cytology monolayer.
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Guirguis Raouf A., Method and apparatus for preparing substances for optical analysis.
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Olin John G. (Carmel Valley CA) Ahlquist Norman C. (Seattle WA), Method and apparatus for sampling of a particle-bearing gas.
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Hofmann Frieder (Kriftel DEX), Method and device for testing the permeability of membrane filters.
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Degen Peter J. (Huntington NY), Method of preparing a supported microporous filtration membrane.
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Ferguson Gary W.,CAX ITX V5G 3V7, Microscope slide with removable layer and method.
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Guirguis Raouf A. (Gaithersburg MD), Modular fluid sample preparation assembly.
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Zahniser David J. (Wellesley MA) Garcia Gerardo L. (Harvard MA), Monolayer device using filter techniques.
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Bowman Larry L. (Kalamazoo County MI), Poppet valve assembly.
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Sternberger Joe E. (Wichita KS), Pressure activated check valve.
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Von Rauch Moriz,DEX, Pressure differential measuring transducer.
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Stenkvist Bjrn G. (Dbelnsgatan 13 S-752 37 Uppsala SEX), Process and device for preparation of cell samples for cytological tests.
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Romanyszyn, Michael T.; Bosko, Robert S., Self-cleaning pre-filter system.
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Weissman Mark (Wayland MA), Slide analysis system with slide having self contained microscope analysis information.
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Leif Robert C. (1030 Mariposa Ave. Coral Gables FL 33146), Swinging buckets.
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Guirguis Amin A.,EGX ; Guirguis Raouf A., System for processing multiple specimens of biological fluid.
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Radcliffe Gail E. ; Lapen Daniel C. ; Festel Charles A., Systems for collecting fluid samples having select concentrations of particles.
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Kraus Menahem A. (Yavne ILX) Yonath Jacob (Rehovot MI ILX) Vitkuske Dan (Ypsilanti MI), Vacuum filter assembly.
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Clark Phillip ; Foley Brian D. ; Pitt Aldo M., Vacuum filter device.
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[미국특허] Filter apparatus and methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses 원문보기

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[미국특허] Filter apparatus and methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses 원문보기

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