초록 ▼

Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate t

Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.

대표청구항 ▼

1. A microncedle device comprising:a substrate comprising a first major surface; at least one microneedle projecting from the first major surface of the subsrrate, the at least one microneedle comprising a base proximate the first major surface of the substrate and a tip distal from the base; a cove

1. A microncedle device comprising:a substrate comprising a first major surface; at least one microneedle projecting from the first major surface of the subsrrate, the at least one microneedle comprising a base proximate the first major surface of the substrate and a tip distal from the base; a cover comprising a first side facing the first major surface of the substrate and a second side facing away from the substrate, wherein the at least one microneedle penetrates through the first side and the second side of the cover; a capillary volume located between the first major surface of the substrate and the first side of the cover; wherein the capillary volume contacts at least a portion of the base of the at least one microneedle, and a channel formed in an outer surface of the at least one microneedle wherein the channel extends from the base towards the tip of the at least one microneedle. 2. The device according to claim 1, wherein the at least one microneedle comprises a plurality of microneedles.3. The device according to claim 1, wherein the cover comprises a liquid impermeable polymeric film.4. A device according to claim 1, further comprising a hydrophilic surface within the capillary volume.5. The device according to claim 4, wherein the hydrophilic surface comprises a coating.6. The device according to claim 1, wherein the channel is in fluid communication with the capillary volume.