IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0752910
(2004-01-07)
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발명자
/ 주소 |
- Chickering, III, Donald E.
- Narasimhan, Sridhar
- Altreuter, David
- Kopesky, Paul
- Keegan, Mark
- Straub, Julie A.
- Bernstein, Howard
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
60 인용 특허 :
33 |
초록
▼
Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to for
Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.
대표청구항
▼
1. A method for making a dry powder blend comprising:(a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material, through an atomizer and into a primary drying chamber having a drying gas inlet, a discharge outlet, and a drying gas flowing therethrough, to form d
1. A method for making a dry powder blend comprising:(a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material, through an atomizer and into a primary drying chamber having a drying gas inlet, a discharge outlet, and a drying gas flowing therethrough, to form droplets comprising the solvent and the bulk material, wherein the droplets are dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in the drying gas, the particles dispersed in the drying gas being a feedstream; (c) adding a dry powder material to the feedstream to form a combined feedstream; and (d) flowing the combined feedstream through an inline jet mill to deagglomerate or grind the particles and dry powder material of the combined feedstream, wherein the jet mill comprises a spiral jet mill or other fluid energy impact mill. 2. The method of claim 1, wherein after step (b) and before step (c) the feedstream is directed through a particle concentration means to separate and remove at least a portion of the drying gas from the feedstream.3. The method of claim 2, wherein the particle concentration means comprises at least one cyclone separator.4. The method of claim 3, wherein the at least one cyclone separator separates between about 50 and 100 vol. % of the drying gas from the particles.5. The method of claim 1, wherein the combined feedstream after step (c) and before step (d) is directed through a particle concentration means to separate and remove at least a portion of the drying gas from the combined feedstream.6. The method of claim 5, wherein the particle concentration means comprises at least one cyclone separator.7. The method of claim 1, wherein step (d) deagglomerates at least a portion of agglomerated particles, if any, while substantially maintaining the size and morphology of the individual particles.8. The method of claim 1, wherein the particles comprise a pharmaceutical agent and the dry powder material is selected from the group consisting of an excipient material, a second pharmaceutical agent, and combinations thereof.9. The method of claim 1, wherein the particles are microparticles comprising a pharmaceutical agent and the dry powder material is in the form of microparticles having a size that is larger than the size of the microparticles which comprise the pharmaceutical agent.10. The method of claim 1, further comprising after step (b) and before step (c) flowing the feedstream through a jet mill to deagglomerate or grind the particles.11. A method for making a dry powder pharmaceutical blend comprising:(a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material which comprises a pharmaceutical agent, through an atomizer and into a primary drying chamber having a drying gas inlet, a discharge outlet, and a drying gas flowing therethrough, to form droplets comprising the solvent and the bulk material, wherein the droplets are dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form microparticles dispersed in the drying gas, the microparticles dispersed in the drying gas together forming a feedstream; (c) adding a dry powder material to the feedstream to form a combined feedstream, the dry powder material being selected from the group consisting of an excipient material, a second pharmaceutical agent, and combinations thereof; and (d) flowing the combined feedstream through an inline jet mill to deagglomerate or grind the microparticles and dry powder material of the combined feedstream, wherein the jet mill comprises a spiral jet mill or other fluid energy impact mill. 12. The method of claim 11, wherein step (d) deagglomerates at least a portion of agglomerated microparticles, if any, while substantially maintaining the size and morphology of the individual particles.13. The method of claim 11, wherein the dry powder material is in the form of microparticles having a size that is larger than the size of the microparticles which comprise the pharmaceutical agent.14. An in-line process for making a dry powder blend comprising:(a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material, through an atomizer and into a primary drying chamber having a drying gas inlet, a discharge outlet, and a drying gas flowing therethrough, to form droplets comprising the solvent and the bulk material, wherein the droplets are dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in the drying gas, the particles dispersed in the drying gas being a feedstream; (c) flowing the feedstream through a first inline jet mill to deagglomerate or grind the particles, wherein the first jet mill comprises a spiral jet mill or other fluid energy impact mill; (d) adding a dry powder material to the feedstream to form a combined feedstream; and (e) optionally flowing the combined feedstream through a second inline jet mill to deagglomerate or grind the particles and dry powder material of the combined feedstream. 15. The process of claim 14, wherein the feedstream after step (b) and before step (c) is directed through a particle concentration means to separate and remove at least a portion of the drying gas from the feedstream.16. The process of claim 15, wherein the particle concentration means comprises at least one cyclone separator.17. The process of claim 14, wherein the combined feedstream after step (d) and before step (e) is directed through a particle concentration means to separate and remove at least a portion of the drying gas from the combined feedstream.18. The process of claim 17, wherein the particle concentration means comprises at least one cyclone separator.19. The process of claim 14, wherein step (c) or step (e) deagglomerate at least a portion of agglomerated particles, if any, while substantially maintaining the size and morphology of the individual particles.20. The process of claim 14, wherein the particles comprise a pharmaceutical agent and the dry powder material is selected from the group consisting of an excipient material, a second pharmaceutical agent, and combinations thereof.21. The process of claim 14, wherein the particles are microparticles comprising a pharmaceutical agent and the dry powder material is in the form of microparticles having a size that is larger than the size of the microparticles which comprise the pharmaceutical agent.22. A pharmaceutical composition comprising a dry powder blend made the method of claim 1.23. A pharmaceutical blend made by claim 11.24. A pharmaceutical composition comprising a dry powder blend made the process of claim 14.
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