Bioerodable polymeric adhesives for tissue repair
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/10
A61K-047/34
A61K-031/765
C08G-063/08
출원번호
US-0923118
(2001-08-06)
§371/§102 date
20010724
(20010724)
발명자
/ 주소
Peterson, Dale R.
Deng, Z. David
Glancy, Todd P.
출원인 / 주소
DePuy Orthopaedics, Inc.
대리인 / 주소
Barnes &
인용정보
피인용 횟수 :
13인용 특허 :
30
초록▼
Improved matrices and adhesives for tissue repair comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of
Improved matrices and adhesives for tissue repair comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
대표청구항▼
1. A pressure sensitive adhesive for tissue repair comprising a thermoplastic lactide-containing terpolymer consisting of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, said terpolymer having an average molecular weight of 1,000 to 3,000, exhibiting
1. A pressure sensitive adhesive for tissue repair comprising a thermoplastic lactide-containing terpolymer consisting of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, said terpolymer having an average molecular weight of 1,000 to 3,000, exhibiting an adhesive strength of about 600 to about 150,000 Pa, and having a water solubility of 0.01 to about 500 mg/ml at about 25° C.2. The pressure sensitive adhesive of claim 1 wherein terpolymer is poly(lactide/glycolide/caprolactone).3. The pressure sensitive adhesive of claim 1 wherein the terpolymer is poly(lactide/glycolide/valerolactone).4. The pressure sensitive adhesive of claim 3 wherein the terpolymer comprises about 35-45% lactide, about 35-45% glycolide, and about 10 to about 30% valerolactone.5. The pressure sensitive adhesive of claim 1 wherein the terpolymer has a glass transition temperature of less than 0° C.6. The pressure sensitive adhesive of claim 1 further comprising a filler.7. The pressure sensitive adhesive of claim 6 wherein the filler is selected from the group consisting of bone chips, tricalcium phosphate, hydroxylapatite, small intestine submucosa, bioglass granules, synthetic polymers, calcium carbonate, calcium sulfate and collagen.8. The pressure sensitive adhesive of claim 1 further comprising a bioactive agent.9. The pressure sensitive adhesive of claim 8 wherein the bioactive agent is a growth factor.10. The pressure sensitive adhesive of claim 9 wherein the growth factor is selected from the group consisting of a fibroblast growth factor, a transforming growth factor, a bone morphogenetic protein, an epidermal growth factor, a platelet-derived growth factor, and an insulin-like growth factor.11. A pressure sensitive adhesive for tissue repair comprising a thermoplastic lactide-containing terpolymer consisting of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, said terpolymer having an average molecular weight of 1,000 to 2,500, exhibiting an adhesive strength of about 600 to about 150,000 Pa and having a water solubility of 0.01 to about 500 mg/ml at about 25° C.12. A pressure sensitive adhesive for tissue repair comprising a thermoplastic lactide-containing terpolymer consisting of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, said terpolymer being a moldable putty, having an average molecular weight of 1,000 to 3,000, exhibiting an adhesive strength of about 600 to about 150,000 Pa and having a water solubility of 0.01 to about 500 mg/ml at about 25° C.13. A pressure sensitive adhesive for tissue repair comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, said terpolymer having an average molecular weight of 1,000 to 3,000, exhibiting an adhesive strength of about 600 to about 150,000 Pa, having a water solubility of 0.01 to about 500 mg/ml at about 25° C., and having a glass transition temperature of less than 0° C.14. A pressure sensitive adhesive for tissue repair comprisinga thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, said terpolymer having an average molecular weight of 1,000 to 3,000, exhibiting an adhesive strength of about 600 to about 150,000 Pa, and having a water solubility of 0.01 to about 500 mg/ml at about 25° C.; and a filler. 15. The pressure sensitive adhesive of claim 14 wherein the filler is selected from the group consisting of bone chips, tricalcium phosphate, hydroxylapatite, small intestine submucosa, bioglass granules, synthetic polymers, calcium carbonate, calcium sulfate and collagen.16. A pressure sensitive adhesive for tissue repair comprisinga thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, said terpolymer having an average molecular weight of 1,000 to 3,000, exhibiting an adhesive strength of about 600 to about 150,000 Pa, having a water solubility of 0.01 to about 500 mg/ml at about 25° C.; and a bioactive agent. 17. The pressure sensitive adhesive of claim 16 wherein the bioactive agent is a growth factor.18. The pressure sensitive adhesive of claim 17 wherein the growth factor is selected from the group consisting of a fibroblast growth factor, a transforming growth factor, a bone morphogenetic protein, an epidermal growth factor, a platelet-derived growth factor, and an insulin-like growth factor.
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이 특허에 인용된 특허 (30)
Bezwada Rao S. (Whitehouse Station NJ) Jamiolkowski Dennis D. (Long Valley NJ), Absorbable polyoxaesters.
Langer Robert S. (Somerville MA) Rosen Howard (Montara CA) Linhardt Robert J. (Iowa City IA) Leong Kam (Cambridge MA), Bioerodible polyanhydrides for controlled drug delivery.
Gerhart Tobin N. (Brockline MA) Laurencin Cato T. (Somerville MA) Domb Abraham J. (Baltimore MD) Langer Robert S. (Newton MA) Hayes Wilson C. (Lincoln MA), Bioerodible polymers for drug delivery in bone.
Kaplan Donald S. (Weston CT) Hermes Matthew (Steamboat Springs CO) Muth Ross R. (Brookfield CT) Kennedy John (Stratford CT), Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgi.
Langer Robert S. (Sommerville MA) Domb Abraham J. (Brookline MA) Laurencin Cato T. (Cambridge MA), Controlled drug delivery high molecular weight polyanhydrides.
Ron Eyal (Lexington MA) Schaub Robert G. (Pelham NH) Turek Thomas J. (Boston MA), Formulations of blood clot-polymer matrix for delivery of osteogenic proteins.
Wahlig Helmut (Darmstadt DEX) Dingeldain Elvira (Dreieich DEX) Braun Dietrich (Darmstadt-Arheilgen DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
English James P. (Birmingham AL) McNeely Gerald W. (Spartanburg SC) Dunn Richard L. (Birmingham AL), Method for making a biodegradable adhesive for soft living tissue.
Krepski Larry R. (White Bear Lake MN) Smith ; II Howell K. (Lauderdale MN) Rasmussen Jerald K. (Stillwater MN) Heilmann Steven M. (N. St. Paul MN), Method of preparing N-acryloyl-a
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Lin Steve T. (Hayward CA) Conjeevaram Seshadri (Stockton CA) Henderson Don J. (Danville CA), Moldable bone-implant material.
Badylak Stephen F. (West Lafayette IN) Geddes Leslie A. (West Lafayette IN) Lantz Gary (Lafayette IN) Coffey Arthur C. (Indianapolis IN), Tissue graft composition.
Badylak Stephen F. (West Lafayette IN) Geddes Leslie A. (West Lafayette IN) Lantz Gary (Lafayette IN) Coffey Arthur C. (Indianapolis IN), Tissue graft composition.
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