IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0397623
(2003-03-26)
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발명자
/ 주소 |
- KenKnight, Bruce H.
- Warren, Jay A.
- Hahn, Stephen John
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출원인 / 주소 |
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대리인 / 주소 |
Schwegman, Lundberg, Woessner &
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인용정보 |
피인용 횟수 :
159 인용 특허 :
71 |
초록
▼
A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical
A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
대표청구항
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1. A method comprising:positioning a first electrode near an implanted intravascular stent; positioning a second electrode at a different position from the first electrode; and delivering at least one pulse of electrical energy between the first and second electrodes at a repetition rate that is les
1. A method comprising:positioning a first electrode near an implanted intravascular stent; positioning a second electrode at a different position from the first electrode; and delivering at least one pulse of electrical energy between the first and second electrodes at a repetition rate that is less than or equal to the order of a frequency between heart depolarizations. 2. The method of claim 1, wherein the positioning the second electrode includes positioning the second electrode at a remote position outside a lumen of the stent.3. The method of claim 2, wherein the positioning the second electrode includes positioning the second electrode external to a patient.4. The method of claim 3, wherein the positioning the second electrode includes positioning the second electrode on a dermal surface.5. The method of claim 1, wherein the positioning the first electrode includes positioning the first electrode within a blood vessel.6. The method of claim 5, wherein the positioning the first electrode includes positioning at least a portion of the first electrode within a lumen of stent.7. The method of claim 5, wherein the positioning the first electrode includes positioning the first electrode within a lumen of the stent such that first and second electrode ends substantially align with respective first and second stent ends.8. The method of claim 1, wherein positioning the first electrode includes positioning the first electrode on a catheter, and wherein the positioning the second electrode includes positioning the second electrode on the same catheter.9. The method of claim 1, wherein at least one of the positioning the first electrode and the positioning the second electrode includes contacting one of the first and second electrodes with the stent.10. The method of claim 1, further including sensing a cardiac signal, and wherein the delivering at least one pulse includes delivering the at least one pulse during a predetermined portion of a cardiac cycle.11. The method of claim 1, in which the delivering at least one pulse includes discharging a capacitor.12. The method of claim 1, in which the delivering at least one pulse includes delivering at least one substantially constant current pulse.13. The method of claim 1, in which the delivering at least one pulse includes delivering at least one substantially direct current (DC) pulse.14. The method of claim 1, in which the delivering at least one pulse includes delivering at least one pulse having a current density between about 1 ampere/cm2 and about 4 amperes/cm2.15. The method of claim 1, in which the positioning the first electrode includes contacting the first electrode with the stent.16. A method comprising:positioning a first electrode near an implanted intravascular stent; positioning a second electrode at a different position from the first electrode; measuring an impedance between the first and second electrodes; determining a desired energy level, using the measured impedance, for inhibiting or reducing stenosis; and delivering electrical energy at the desired energy level between the first electrode and the second electrode to inhibit or reduce stenosis. 17. The method of claim 16, wherein the positioning the second electrode includes positioning the second electrode at a remote position outside a lumen of the stent.18. The method of claim 17, wherein the positioning the second electrode includes positioning the second electrode external to a patient.19. The method of claim 18, wherein the positioning the second electrode includes positioning the second electrode on a dermal surface.20. The method of claim 16, wherein the positioning the first electrode includes positioning the first electrode within a blood vessel.21. The method of claim 20, wherein the positioning the first electrode includes positioning at least a portion of the first electrode within a lumen of stent.22. The method of claim 20, wherein the positioning the first electrode includes positioning the first electrode within a lumen of the stent such that first and second electrode ends substantially align with respective first and second stent ends.23. The method of claim 16, wherein positioning the first electrode includes positioning the first electrode on a catheter, and wherein the positioning the second electrode includes positioning the second electrode on the same catheter.24. The method of claim 16, wherein at least one of the positioning the first electrode and the positioning the second electrode includes contacting one of the first and second electrodes with the stent.25. The method of claim 16, further including sensing a cardiac signal, and wherein the delivering electrical energy includes delivering at least one pulse during a predetermined portion of a cardiac cycle.26. The method of claim 16, in which the delivering electrical energy includes discharging a capacitor.27. The method of claim 16, in which the delivering electrical energy includes delivering at least one substantially constant current pulse.28. The method of claim 16, in which the delivering electrical energy includes delivering at least one substantially direct current (DC) pulse.29. The method of claim 16, in which the delivering electrical energy includes delivering at least one pulse having a current density between about 1 ampere/cm2 and about 4 amperes/cm2.30. The method of claim 16, in which the positioning the first electrode includes contacting the first electrode with the stent.31. A method comprising:positioning a first electrode near an implanted intravascular stent; positioning a second electrode at a different position from the first electrode; measuring an impedance between the first and second electrodes; determining a desired energy level, using the measured impedance, wherein the desired energy level is appropriate for inhibiting or reducing stenosis without affecting nearby myocardial tissue; delivering electrical energy at the desired energy level between the first and second electrodes. 32. The method of claim 31, wherein the positioning the second electrode includes positioning the second electrode at a remote position outside a lumen of the stent.33. The method of claim 32, wherein the positioning the second electrode includes positioning the second electrode external to a patient.34. The method of claim 33, wherein the positioning the second electrode includes positioning the second electrode on a dermal surface.35. The method of claim 31, wherein the positioning the first electrode includes positioning the first electrode within a blood vessel.36. The method of claim 35, wherein the positioning the first electrode includes positioning at least a portion of the first electrode within a lumen of stent.37. The method of claim 35, wherein the positioning the first electrode includes positioning the first electrode within a lumen of the stent such that first and second electrode ends substantially align with respective first and second stent ends.38. The method of claim 31, wherein positioning the first electrode includes positioning the first electrode on a catheter, and wherein the positioning the second electrode includes positioning the second electrode on the same catheter.39. The method of claim 31, wherein at least one of the positioning the first electrode and the positioning the second electrode includes contacting one of the first and second electrodes with the stent.40. The method of claim 31, further including sensing a cardiac signal, and wherein the delivering electrical energy includes delivering at least one pulse during a predetermined portion of a cardiac cycle.41. The method of claim 31, in which the delivering electrical energy includes discharging a capacitor.42. The method of claim 31, in which the delivering electrical energy includes delivering at least one substantially constant current pulse.43. The method of claim 31, in which the delivering electrical energy includes delivering at least one substantially direct current (DC) pulse.44. The method of claim 31, in which the delivering electrical energy includes delivering at least one pulse having a current density between about 1 ampere/cm2 and about 4 amperes/cm2.45. The method of claim 31, in which the measuring the impedance includes:delivering a test current between the first and second; and measuring a resulting voltage between the first and second electrodes, the resulting voltage resulting from the delivering the test current. 46. The method of claim 31, in which the determining the desired energy level of the electrical energy includes determining a voltage amplitude of the electrical energy.47. The method of claim 46, in which the determining the voltage amplitude of the electrical energy includes calculating the voltage amplitude using the measured impedance and a predetermined critical current density value.48. The method of claim 47, in which the calculating the voltage amplitude includes multiplying the predetermined critical current density value by a surface area of at least one of the first and second electrodes.49. The method of claim 31, in which the positioning the first electrode includes contacting the first electrode with the stent.50. A method comprising:positioning a first electrode near an implanted intravascular stent; positioning a second electrode at a different position from the first electrode; measuring an impedance using the first and second electrodes; determining a desired energy level, using the measured impedance, in which the desired energy level is determined using a predetermined desired current density between the first and second electrodes; and delivering electrical energy between the first and second electrodes at the desired energy level to inhibit or reduce stenosis. 51. The method of claim 50, wherein the positioning the second electrode includes positioning the second electrode at a remote position outside a lumen of the stent.52. The method of claim 51, wherein the positioning the second electrode includes positioning the second electrode external to a patient.53. The method of claim 52, wherein the positioning the second electrode includes positioning the second electrode on a dermal surface.54. The method of claim 50, wherein the positioning the first electrode includes positioning the first electrode within a blood vessel.55. The method of claim 54, wherein the positioning the first electrode includes positioning at least a portion of the first electrode within a lumen of stent.56. The method of claim 54, wherein the positioning the first electrode includes positioning the first electrode within a lumen of the stent such that first and second electrode ends substantially align with respective first and second stent ends.57. The method of claim 55, wherein positioning the first electrode includes positioning the first electrode on a catheter, and wherein the positioning the second electrode includes positioning the second electrode on the same catheter.58. The method of claim 50, wherein at least one of the positioning the first electrode and the positioning the second electrode includes contacting one of the first and second electrodes with the stent.59. A method comprising:positioning a first electrode near an implanted intravascular stent; positioning a second electrode at a different position from the first electrode; and delivering a substantially constant DC current between the first electrode and the second electrode; measuring an impedance using the substantially constant DC current; determining a desired energy level, using the measured impedance, for inhibiting or reducing stenosis; and delivering electrical energy between the first and second electrodes at the desired energy level to inhibit or reduce stenosis. 60. The method of claim 59, wherein the positioning the second electrode includes positioning the second electrode at a remote position outside a lumen of the stent.61. The method of claim 59, wherein the positioning the second electrode includes positioning the second electrode external to a patient.62. The method of claim 61, wherein the positioning the second electrode includes positioning the second electrode on a dermal surface.63. The method of claim 59, wherein the positioning the first electrode includes positioning the first electrode within a blood vessel.64. The method of claim 63, wherein the positioning the first electrode includes positioning at least a portion of the first electrode within a lumen of stent.65. The method of claim 63, wherein the positioning the first electrode includes positioning the first electrode within a lumen of the stent such that first and second electrode ends substantially align with respective first and second stent ends.66. The method of claim 59, wherein positioning the first electrode includes positioning the first electrode on a catheter, and wherein the positioning the second electrode includes positioning the second electrode on the same catheter.67. The method of claim 59, wherein at least one of the positioning the first electrode and the positioning the second electrode includes contacting one of the first and second electrodes with the stent.68. The method of claim 59, in which the positioning the first electrode includes contacting the first electrode with the stent.69. The method of claim 16, in which the determining the desired energy level includes establishing the desired energy at a level that is sufficient to inhibit or reduce stenosis without impairing nearby myocardial cells.70. The method of claim 16, in which the determining the desired energy level includes establishing the desired energy at an energy that is sufficient to affect smooth muscle cells in a medial layer of a blood vessel without impairing nearby myocardial cells.71. The method of claim 16, in which the measuring the impedance includes delivering a test current, measuring a resulting voltage, and calculating the impedance using the test current and the measured resulting voltage.72. The method of claim 71, in which the delivering the test current includes delivering a subthreshold alternating current.73. The method of claim 72, in which the delivering the subthreshold alternating current includes delivering the subthreshold alternating current at a frequency between about 5 kiloHertz and about 50 kiloHertz.74. The method of claim 71, in which the delivering the test current includes delivering a test current having an amplitude between about 10 microamperes and about 50 microamperes.75. The method of claim 16, in which the positioning the first electrode includes positioning an electrode on a balloon portion of a catheter.76. The method of claim 16, in which the positioning the first electrode includes positioning a coil spring electrode.
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