Medical device having anti-infective and contraceptive properties
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-033/08
A61K-031/19
A61K-033/40
A01N-025/00
출원번호
US-0336392
(1999-06-18)
발명자
/ 주소
Green, Terrence R.
Fellman, Jack
출원인 / 주소
Oxibio, Inc.
대리인 / 주소
Heller Ehrman LLP
인용정보
피인용 횟수 :
65인용 특허 :
93
초록▼
There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to
There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to confer to the site microbicidal or virucidal activity. Devices in the disclosure designed as vaginal inserts also exhibit contraceptive spermicidal activity. The coated devices or devices having the inventive polymeric material interspersed throughout are formed into appropriate shapes according to their contemplated uses (such as catheters or Foley catheters). Further, the present invention provides devices for providing therapeutic anti-microbial activity into an infected body cavity or on an infected wound site.
대표청구항▼
1. An implantable anti-infective medical device selected from the group consisting of catheters, prostheses, shunts, stents, and leadwires, said device comprising a solid polymeric matrix selected from the group selected from a two component elastomer formulation, room temperature vulcanization elas
1. An implantable anti-infective medical device selected from the group consisting of catheters, prostheses, shunts, stents, and leadwires, said device comprising a solid polymeric matrix selected from the group selected from a two component elastomer formulation, room temperature vulcanization elastomers, thermoplastic polymers, and hydrogels, containing within the matrix solid particles of an oxidant-producing component comprising a reducing agent, an oxidizing agent consisting of anhydrous alkali iodine oxide salts, inorganic and organic peracids, iodine pentoxide, an oxidase enzyme, and combinations thereof, that, when wetted, causes the formation of an oxidant and sustained release of the thus-formed oxidant into and about the polymeric matrix so that the matrix serves as an anti-infective reservoir;wherein the oxidant is iodine generated at a quantity sufficient so that free-iodine concentration near a surface of the device should reach a level of at least 5 ppm;wherein the polymeric matrix is formed from room temperature vulcanization elastomers when the oxidizing agent is selected to be the oxidase enzyme;wherein the device further comprises an iodide salt when the oxidizing agent is inorganic and organic peracids or the oxidase enzyme.2. The anti-infective medical device of claim 1 where the oxidant is elemental iodine.3. The anti-infective medical device of claim 1 where the oxidant-producing component further comprises a proton donor that, in combination with the reducing agent and the oxidizing agent, forms solid particles dispersed within the polymeric matrix in sufficient amount to provide anti-infective activity to the medical device.4. The anti-infective medical device of claim 3 where the proton donor is selected from the group consisting of organic acids, inorganic acids, iodine pentoxide, and other acid anhydrides.5. The anti-infective medical device of claim 4 where the proton donor is selected from the group consisting of perborates and organoperoxy acids.6. The anti-infective medical device of claim 5 where the proton donor has a concentration of from about 0.01% to about 16% by weight of the polymeric material.7. The anti-infective medical device of claim 3 wherein the polymeric matrix is the room temperature vulcanization elastomers and where the proton donor is a hydrogen peroxide-generating oxidase enzyme selected from the group consisting of glucose oxidase and diamine oxidase.8. The anti-infective medical device of claim 7 where the glucose oxidase has a specific activity of from about 2,000 IU/g to about 200,000 IU/g, the diamine oxidase has a specific activity of from about 50 U/g to about 800 IU/g, and the concentration of the glucose oxidase or diamine oxidase is from about 0.01% to about 2.5% by weight of the polymeric material.9. The anti-infective medical device of claim 7 further comprising a peroxidase enzyme, where the glucose oxidase or diamine oxidase concentration is at least about 0.01% by weight of the polymeric matrix, the peroxidase enzyme is present at a concentration of at least about 0.01% by weight of the polymeric matrix, and the sum concentration of the oxidase and peroxidase enzymes is from of about 0.02% to about 2.5% by weight of the polymeric matrix.10. The anti-infective medical device of claim 1 where the reducing agent is a water soluble iodide salt.11. The anti-infective medical device of claim 10 where the reducing agent is an alkali iodide salt.12. The anti-infective medical device of claim 11 where the alkali iodide salt has a concentration of about 0.01% to about 16% by weight of the polymeric matrix.13. The anti-infective medical device of claim 1 where the oxidizing agent is selected from the group consisting of anhydrous alkali iodate salts, iodine pentoxide, and mixtures thereof.14. The anti-infective medical device of claim 1 where the polymeric matrix comprises a hydrophobic polymer selected from the group consisting of polyureas, polyurethanes, poly(ethylene/-vinyl acetate), polyvinylchloride, polyesters, polyamides, polycarbonate, polyethylene, polypropylene, polystyrenes, polytetrafluoroethylene, and silicone polymers.15. The anti-infective medical device of claim 14 where the oxidant is elemental iodine.16. The anti-infective medical device of claim 14 where the oxidant-producing component further comprises a proton donor that, in combination with the reducing agent and the oxidizing agent, forms solid particles dispersed within the polymeric matrix in sufficient amount to provide anti-infective activity to the medical device.17. The anti-infective medical device of claim 14 where the reducing agent is a water soluble iodide salt.18. The anti-infective medical device of claim 17 where the reducing agent is an alkali iodide salt.19. The anti-infective medical device of claim 18 where the alkali iodide salt has a concentration of about 0.01% to about 16% by weight of the polymeric matrix.20. The anti-infective medical device of claim 14 where the oxidizing agent is selected from the group consisting of anhydrous alkali iodine oxide salts, iodine pentoxide, inorganic and organic peracids, and combinations thereof.21. The anti-infective medical device of claim 20 where the oxidizing agent is selected from the group consisting of anhydrous alkali iodate salts, iodine pentoxide, and mixtures thereof.22. The anti-infective medical device of claim 16 where the proton donor is selected from the group consisting of organic acids, inorganic acids, iodine pentoxide, and other acid anhydrides.23. The anti-infective medical device of claim 22 where the proton donor is selected from the group consisting of perborates and organoperoxy acids.24. The anti-infective medical device of claim 23 where the proton donor has a concentration of from about 0.01% to about 16% by weight of the polymeric material.25. The anti-infective medical device of claim 16 where the polymeric matrix is the room temperature vulcanization elastomers when the proton donor is a hydrogen peroxide-generating oxidase enzyme selected from the group consisting of glucose oxidase and diamine oxidase.26. The anti-infective medical device of claim 25 where the glucose oxidase has a specific activity of from about 2,000 IU/g to about 200,000 IU/g, the diamine oxidase has a specific activity of from about 50 IU/g to about 800 IU/g, and the concentration of the glucose oxidase or diamine oxidase is from about 0.01% to about 2.5% by weight of the polymeric material.27. The anti-infective medical device of claim 25 further comprising a peroxidase enzyme, where the glucose oxidase or diamine oxidase concentration is at least about 0.01% by weight of the polymeric matrix, the peroxidase enzyme is present at a concentration of at least about 0.01% by weight of the polymeric matrix, and the sum concentration of the oxidase and peroxidase enzymes is from of about 0.02% to about 2.5% by weight of the polymeric matrix.28. The anti-infective medical device of claim 1 selected from the group consisting of catheters and prostheses.29. An implantable anti-infective medical device selected from the group consisting of catheters, prostheses, shunts, stents, and leadwires, comprising a solid polymeric matrix, comprising a solid polymeric matrix selected from the group consisting of room temperature vulcanization elastomers that contain within the matrix solid particles of an oxidant-producing component comprising an iodide salt and an oxidizing agent consisting of substrate oxidoreductases which, when allowed to contact oxidoreductase substrates in body fluids causes the formation of an oxidant and sustained release of the thus-formed oxidant into and about the polymeric matrix so that the matrix serves as an anti-infective reservoir;wherein the oxidant is iodine generated at a quantity sufficient so that free-iodine concentration near a surface of the device should reach a level of at least 5 ppm.30. An implantable anti-infective medical device selected from the group consisting of catheters, prostheses, shunts, stents, and leadwires, comprising a solid polymeric matrix selected from the group consisting of thermoplastic polymers and thermosetting polymers, containing within the matrix solid particles of a non-enzyme, oxidant-producing component comprising an oxidizing agent and an iodide salt which, when allowed to contact body fluids, generates an oxidant and sustained release of the thus-formed oxidant into and about the polymeric matrix so that the matrix serves as an anti-infective reservoir, wherein the oxidant is iodine generated at a quantity sufficient so that free-iodine concentration near a surface of the device should reach a level of at least 5 ppm.
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Domb Abraham J. (Baltimore MD) Shikani Alain (Baltimore MD) Haffer Andrew S. T. (Baltimore MD) Maniar Manoj (Baltimore MD), Anti-infective and anti-inflammatory releasing systems for medical devices.
Galley Edward (Nottinghamshire GB2) Godfrey Dene C. (Nottinghamshire GB2) Guthrie Walter G. (Nottinghamshire GB2) Hodgkinson Darren M. (Nottinghamshire GB2) Linnington Helen L. (Nottinghamshire GB2), Anti-microbial compositions.
Sawan Samuel P. (Tyngsboro MA) Dollinger Harli M. (Dracut MA) Horne ; Jr. Herbert W. (Framingham MA), Contraceptive intracervical device and novel nonsystemic agents for the prevention of conception and disease.
Leveen Harry H. (321 Confederate Cir. Charleston SC 29407) Leveen Robert F. (312 Lombard St. Philadelphia PA 19147) Leveen Eric G. (19 Palmetto Rd. Charleston SC 29407), Contraceptive sponge and tampon.
Bettinger George E. (Wilmington DE) Pohland Hermann W. (Wilmington DE) Applegate Lynn E. (Wilmington DE), Control of biological growth in reverse osmosis permeators.
Moench Thomas R. (703 Stags Head Rd. Baltimore MD 21286-1446) Cone Richard A. (225 W. Lafayette Ave. Baltimore MD 21217), Device for acidic buffering and method for inactivation of pathogens.
Gutnick Morton (8329 Fairview Rd. Elkins Park PA 19117), Devices and methods for the prevention of transmission of venereal disease and non-gonococcal genital infections.
Cyprien Guy (L\Hay les Roses FRX) Fisch Alain (Paris FRX) Haggiage Johnny (Lyons FRX) Porte Hugues (Caluire FRX) Prazuck Thierry (Paris FRX) Torres Ghislaine (Lyons FRX), Diorganopolysiloxane dosage forms for the controlled release of iodine values.
Schlitzer Ronald L. (Fort Worth TX) Dassanayake N. L. (Arlington TX) Bhatia Rajkumar P. (Arlington TX), Double redox system for disinfecting contact lenses.
Eury Robert P. (Cupertino CA) Garguilo Darlene (Fremont CA) Villareal Plaridel (San Jose CA), Drug loaded polymeric material and method of manufacture.
Terrence R. Green ; Jack H. Fellman, Electrolytic generation of nascent iodine as a method of treatment and for the prevention of infections associated with medical implant devices.
Sampson Richard L. ; Sampson Allison Hawkins, Electrolytic process and apparatus for the controlled oxidation and reduction of inorganic and organic species in aqueou.
Sampson Richard L. (San Antonio TX) Sampson Allison H. (San Antonio TX), Electrolytic process and apparatus for the controlled oxidation of inorganic and organic species in aqueous solutions.
Dresdner ; Jr. Karl P. (235 W. 48th St. ; Apt. #18N New York City NY 10036) Dangman Kenneth H. (400 Riverside Dr. ; Apt. #1A New York City NY 10032) Jazlowiecki Edward A. (15 Sachems Trail West Simsb, Flexible protective medical gloves and methods for their use.
Herweck Steve A. (Nashua NH) Karwoski Theodore (Hollis NH) Martakos Paul (Pelham NH), Implantable prosthetic device for the delivery of a bioactive material.
Kessler Jack H. (335 Montclair Ave. Glen Ellyn IL 60137) Rosenbaum Robert S. (69 Grayfield Ave. West Roxbury MA 02132), In situ sporicidal disinfectant.
Fox ; Jr. Charles L. (New York NY) Modak Shanta M. (River Edge NJ) Sampath Lester A. (Nyack NY), Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same.
Cohen Robert S. (New York NY) Pierce James M. (Coral Gables FL) Kinsey William H. (Coral Gables FL), Intra-vaginal device and method for sustained drug release.
Brodman Michael L. (Great Neck NY) Kirschbaum Warren (Kemah TX) Weinberg Steven L. (League City TX), Intravaginal device and method for delivering a medicament.
LeVeen Harry H. (321 Confederate Cir. Charleston) LeVeen Eric G. (19 Palmetto Rd. Charleston SC 29407) LeVeen Robert F. (312 Lombard St. Philadelphia PA 19147), Iodine contraceptive sponge.
Piechocki Duane (Pleasantville NY) Bormann Thomas J. (Melville NY) Gsell Thomas C. (Glen Head NY) Pascale Frank R. (Glen Cove NY) Matkovich Vlado I. (Glen Cove NY), Iodine disinfection method using a gaseous iodine treated porous medium.
Messier Pierre Jean (14163E ; Route 117 ; Mirabel Saint-Janvier ; Quebec CAX J7J 1M3 ), Iodine/resin disinfectant and a procedure for the preparation thereof.
Buxton Ian R. (Cambridgeshire GB2) Leslie Stewart T. (Cambridge GB2) Malkowska Sandra T. A. (Cambridge GB2) Marchant Joanne (Cambridge GB2), Iodophor-containing suppository.
Cardarelli Nathan F. (Barberton OH), Method and composition for the long term controlled release of a non-persistent organotin pesticide from an inert monoli.
Cardarelli Nathan F. (Barberton OH), Method and composition for the long term controlled release of a non-persistent organotin pesticide from an inert monoli.
Shikani Alain H. (Ruxton MD) Domb Abraham J. (Efrat ILX), Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other s.
Domb Abraham J. (Efrat MD ILX) Shikani Alain H. (Ruxton MD), Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environ.
Moench Thomas R. (703 Stags Head Rd. Baltimore MD 21286-1446) Cone Richard A. (225 W. Lafayette Ave. Baltimore MD 21217), Method for acidifying an ejaculate of semen.
Shlenker Robin Renee Thill ; Lester David J. ; Solomons Clive C. ; Plamthottam Sebastian S., Method of forming a membrane especially a latex or polymer membrane including multiple discrete layers.
Shlenker Robin Renee Thill (Malibu CA) Lester David J. (Littleton CO) Solomons Clive C. (Denver CO) Plamthottam Sebastian S. (Upland CA), Method of forming a membrane, especially a latex or polymer membrane, including multiple discrete layers.
Strickman Robert L. (Lawrence Rd. ; R.D. 1 Bridgeton NJ 08302) Fournier Erick-Pierre (30 Park Ave. New York NY 10016) Strickman Melvyn B. (Lawrence Rd. ; R.D. 1 Bridgeton NJ 08302), Method of manufacturing a disposable contraceptive intravaginal cervical barrier.
Kessler Jack H. (Ashland MA), Method to clean and disinfect pathogens on the epidermis by applying a composition containing peroxidase, iodide compoun.
Garfield Robert E. (Friendswood TX) Balaban Alexandru T. (Galveston TX) Seitz William A. (Dickinson TX) Klein Douglas J. (Galveston TX) Lesko Melanie (Friendswood TX), N-nitroso-N-substituted hydroxylamines as nitric oxide donors.
Karakelle Mutlu (Spring Valley OH) Benson C. David (Waynesville OH) Taller Robert A. (Centerville OH) Lee Min-Shiu (Spring Valley OH) Khan Mohammad A. (Sandy UT), Polyurethane sponge having rapid iodine release.
LeVeen, Harry H.; Rubricius, Jeanette L.; LeVeen, Eric G.; LeVeen, Robert F., Thermoplastic polyurethane article treated with iodine for antibacterial use.
Sokal David C. ; Dorflinger Laneta J. ; Luukkainen J.V. Tapani,FIX ; Martin Parthena M., Vaginal device for preventing conception or the transmission of sexually transmitted diseases, or both.
Shaw, Wendy J.; Yonker, Clement R.; Fulton, John L.; Tarasevich, Barbara J.; McClain, James B.; Taylor, Doug, Medical implants and methods of making medical implants.
Siegel, Dan G.; Nelson, Kevin Philip; Pockat, Gregory Robert; Schell, Thomas Andrew; Berbert, Otacilio Teixeira; Michaud, Ryan Arthur; Mengel, Matthew LeRoy; Latreille, Douglas Mark, Method for distributing a myoglobin-containing food product.
Hoffman, Douglas Robert; Smiltneek, Andrea Jo; Carney, Sara Ann; Wenzel, Scott W.; Koenig, David William; Seidling, Jeffery Richard, Substrates providing multiple releases of active agents.
Fulton, John L.; Deverman, George S.; Matson, Dean W.; Yonker, Clement R.; Taylor, C. Douglas; McClain, James B.; Crowley, Joseph M., System and method for enhanced electrostatic deposition and surface coatings.
Fulton, John L.; Deverman, George S.; Matson, Dean W.; Yonker, Clement R.; Taylor, C. Douglas; McClain, James B.; Crowley, Joseph M., System and method for enhanced electrostatic deposition and surface coatings.
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