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An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to d

An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to detect in a selected tissue region of the subject a manifestation caused by the delivered drug. The local controller is constructed and arranged to receive data from or transmit data to the optical probe and the drug delivery module. The local controller is arranged to correlate optical data, received from the optical probe, to selected data and provide signals to the drug delivery module for adjusting the amounts of the drug to be delivered into the subject.

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1. An interactive drug delivery system comprising:a drug delivery module constructed and arranged to deliver selected amounts of a drug into a subject; an optical probe constructed and arranged to detect in vivo in a selected biological tissue region of said subject a manifestation caused by the del

1. An interactive drug delivery system comprising:a drug delivery module constructed and arranged to deliver selected amounts of a drug into a subject; an optical probe constructed and arranged to detect in vivo in a selected biological tissue region of said subject a manifestation caused by the delivered drug, said manifestation in said selected biological tissue region altering photon migration in said tissue due to said delivered drug; and a local controller constructed and arranged to receive data from or transmit data to said optical probe and said drug delivery module; said local controller being arranged to correlate optical data, related to said manifestation in said biological tissue region, received from said optical probe to selected data and provide signals to said drug delivery module for adjusting the amounts of the drug to be delivered into said subject. 2. The system of claim 1 further including a central controller remotely located from and in wireless communication with said local controller, central controller constructed and arranged to receive data from said local controller and provide to said local controller data for adjusting the amounts of said drug to be delivered into said subject.3. The system of claim 1 or 2 further including a temperature probe coupled to said local controller.4. The system of claim 3 wherein said temperature probe uses an infra-red beam to measure a local temperature of a tissue region.5. The system of claim 1 or 2 further including an electrical probe coupled to said local controller.6. The system of claim 1 or 2 wherein said optical probe is a TRS system.7. The system of claim 1 or 2 wherein said optical probe is a phase modulation system.8. The system of claim 1 or 2 wherein said optical probe is a phased array.9. The system of claim 1 or 2 wherein said optical probe is a phase cancellation system.10. The system of claim 1 or 2 wherein said optical probe is an amplitude cancellation system.11. The system of claim 1 or 2 wherein said drug delivery module includes an electrical controller designed to regulate the rate of the delivered drug based on the signals from said local controller.12. An interactive drug delivery method comprising:delivering by a drug delivery module selected amounts of a drug into a subject; optically detecting in vivo in a selected biological tissue region of said subject a manifestation caused by the delivered drug by an optical probe, said manifestation in said selected biological tissue region altering photon migration in said tissue due to said delivered drug; receiving data from or transmitting data to said optical probe and said drug delivery module by a local controller; correlating optical data, related to said manifestation in said biological tissue region, received from said optical probe to selected data stored in said local controller; and providing signals to said drug delivery module for adjusting the amounts of the drug to be delivered into said subject. 13. The interactive drug delivery method of claim 12 further including regulating the rate of the delivered drug based on signals from said local controller.14. The interactive drug delivery method of claim 12 including measuring tissue temperature.15. The interactive drug delivery method of claim 14 wherein said measuring temperature includes using an infra-red beam for measuring a local temperature of a tissue region.16. The interactive drug delivery method of claim 12 further including measuring electrical signals with an electrical probe.