IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0007423
(2001-10-22)
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발명자
/ 주소 |
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출원인 / 주소 |
- Alcon Manufacturing, Ltd.
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인용정보 |
피인용 횟수 :
2 인용 특허 :
20 |
초록
The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives.
대표청구항
▼
1. A multi-dose ophthalmic composition comprising 0.01 to 2.0% w/v of a borate compound selected from the group consisting of boric acid, pharmaceutically acceptable salts of boric acid, and combinations thereof; 0.01 to 2.0% w/v of an amino alcohol having a molecular weight of 60 to 200 grams/mole;
1. A multi-dose ophthalmic composition comprising 0.01 to 2.0% w/v of a borate compound selected from the group consisting of boric acid, pharmaceutically acceptable salts of boric acid, and combinations thereof; 0.01 to 2.0% w/v of an amino alcohol having a molecular weight of 60 to 200 grams/mole; and water.2. An ophthalmic composition according to claim 1, wherein the composition further comprises 0.01 to 5.0% w/v of a polyol.3. An ophthalmic composition according to claim 2 wherein the polyol comprises propylene glycol.4. An ophthalmic composition according to claim 2, wherein the polyol is selected from the group consisting of mannitol, glycerin, xylitol, sorbitol, and combinations thereof.5. An ophthalmic composition according to claim 4, wherein the polyol comprises sorbitol.6. An ophthalmic composition according to claim 5, wherein the polyol further comprises propylene glycol.7. An ophthalmic composition according to claim 2, wherein the borate concentration is 0.3 to 1.2% w/v and the polyol concentration is 0.6 to 2.0% w/v.8. An ophthalmic composition according to claim 1, wherein the amino alcohol is selected from the group consisting of 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-methyl-1-propanol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), 2-amino-1-butanol (AB), and combinations thereof.9. An ophthalmic composition according to claim 8, wherein the amino alcohol comprises AMP.10. An ophthalmic composition according to claim 9, wherein the composition further comprises 0.01 to 5.0% of a polyol.11. An ophthalmic composition according to claim 10, wherein the borate concentration is 0.3 to 1.2% w/v and the polyol concentration is 0.6 to 2.0% w/v.12. An ophthalmic composition according to claim 10, wherein the polyol comprises propylene glycol.13. An ophthalmic composition according to claim 10, wherein the polyol is selected from the group consisting of mannitol, glycerin, xylitol, sorbitol, and combinations thereof.14. An ophthalmic composition according to claim 13, wherein the polyol comprises sorbitol.15. An ophthalmic composition according to claim 14, wherein the polyol further comprises propylene glycol.16. An ophthalmic composition according to claim 1, wherein the composition does not contain a conventional anti-microbial preservative.17. An ophthalmic composition according to claim 16, wherein the composition is adapted for use as an artificial tear.18. An ophthalmic composition according to claim 16, wherein the composition is adapted for use as an ocular lubricant.19. An aqueous solution for disinfecting contact lenses, comprising:0.01 to 2.0% w/v of an amino alcohol having a molecular weight of 60 to 200 grams/mole; an antimicrobial agent in an amount effective to disinfect a contact lens; a borate/polyol buffer system, said buffer system comprising a borate compound in an amount of 0.01 to 2.0% w/v and a polyol in an amount of 0.01 to 5.0% w/v; and water. 20. An aqueous solution according to claim 19, wherein the borate compound is selected from the group consisting of boric acid, pharmaceutically acceptable salts of boric acid, and combinations thereof; and the amino alcohol is selected from the group consisting of 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-methyl-1-propanol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), 2-amino-1-butanol (AB), and combinations thereof.21. A solution according to claim 20, wherein the amino alcohol comprises AMP.22. A sterile, multi-dose ophthalmic composition comprising 0.1 to 2.0% w/v of an amino alcohol having a molecular weight of 60 to 200 grams/mole; a borate/polyol buffer system, said buffer system comprising a borate compound in an amount of 0.01 to 2.0% w/v and a polyol in an amount of 0.01 to 5.0% w/v; and water, wherein said composition is adapted for use as an artificial tear or ocular lubricant and does not contain a conventional anti-microbial preservative.23. A composition according to claim 22, wherein the borate compound is selected from the group consisting of boric acid, pharmaceutically acceptable salts of boric acid, and combinations thereof; and the amino alcohol is selected from the group consisting of 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-methyl-1-propanol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), 2-amino-1-butanol (AB), and combinations thereof.24. A composition according to claim 23, wherein the polyol comprises propylene glycol.25. A composition according to claim 23, wherein the polyol is selected from the group consisting of mannitol, glycerin, xylitol, sorbitol, and combinations thereof.26. A composition according to claim 25, wherein the amino alcohol comprises AMP.27. A composition according to claim 25, wherein the polyol further comprises propylene glycol.28. A composition according to claim 27, wherein the amino alcohol comprises AMP.29. A composition according to claim 22, wherein the amino alcohol comprises AMP.
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