Linkage of agents to body tissue using microparticles and transglutaminase
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/45
A61K-038/48
A61K-038/00
C12N-011/02
C07K-017/02
출원번호
US-0620783
(2000-07-21)
발명자
/ 주소
Green, Howard
Compton, Bruce J.
Corey, George D.
Djian, Philippe
출원인 / 주소
Pericor Science, Inc.
대리인 / 주소
Wolf, Greenfield &
인용정보
피인용 횟수 :
33인용 특허 :
281
초록▼
Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the groups are part of a polymer containing
Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the groups are part of a polymer containing at least two contiguous linked lysines or at least three contiguous linked glutamines.
대표청구항▼
1. A composition comprisinga microparticle comprising an active agent and a polymer having transglutaminase substrate reactive groups, wherein the transglutaminase substrate reactive groups are surface available, and the polymer comprises a polymer of amino acids having at least three contiguous lin
1. A composition comprisinga microparticle comprising an active agent and a polymer having transglutaminase substrate reactive groups, wherein the transglutaminase substrate reactive groups are surface available, and the polymer comprises a polymer of amino acids having at least three contiguous linked glutamines. 2. The composition of claim 1, wherein the transglutaminase substrate reactive groups are surface available in an amount sufficient to attach the microparticle to a body tissue in the presence of endogenous transglutaminase.3. The composition of claim 1, wherein the transglutaminase substrate reactive groups are surface available in an amount sufficient to attach the microparticle to a body tissue in the presence of exogenous transglutaminase.4. The composition of claim 1, wherein the polymer is covalently linked to a synthetic polymer.5. The composition of claim 1, wherein the polymer comprises a polymer of amino acids and wherein at least 20% of the amino acids are glutamines.6. The composition of claim 1, wherein the active agent is selected from the group consisting of a cosmetic agent, a bulking agent, a hair conditioning agent, a hair fixative, a sunscreen agent, a moisturizing agent, a depilatory agent, an anti-nerve gas agent, a film forming agent, a vitamin, an insect repellant, a coloring agent, a pharmaceutical agent, a ligand-receptor complex and a receptor of a ligand-receptor complex.7. A kit comprisinga package including a container containing the composition of claim 1 and instructions for topically administering the composition to a skin surface. 8. A composition comprisinga microparticle comprising an active agent and a polymer having transglutaminase substrate reactive groups, wherein the microparticle is non-biodegradable, and the transglutaminase substrate reactive groups are surface available, and the polymer comprises a polymer of amino acids having at least three contiguous linked lysines. 9. The composition of claim 8, wherein the transglutaminase substrate reactive groups are surface available in an amount sufficient to attach the microparticle to a body tissue in the presence of endogenous transglutaminase.10. The composition of claim 8, wherein the transglutaminase substrate reactive groups are surface available in an amount sufficient to attach the microparticle to a body tissue in the presence of exogenous transglutaminase.11. The composition of claim 8, wherein the polymer comprises a polymer of amino acids and wherein at least 50% of the amino acids are lysine.12. The composition of claim 8, wherein the active agent is selected from the group consisting of a cosmetic agent, a bulking agent, a hair conditioning agent, a hair fixative, a sunscreen agent, a moisturizing agent, a depilatory agent, an anti-nerve gas agent, a film forming agent, a vitamin, an insect repellant, a coloring agent, a pharmaceutical agent, a ligand-receptor complex and a receptor of a ligand-receptor complex.13. A kit comprisinga package including a container containing the composition of claim 8 and instructions for topically administering the composition to a skin surface. 14. A method of treating a subject to attach microparticles to a body tissue of the subject comprisingcontacting the body tissue in the presence of endogenous or exogenous transglutaminase with microparticles having surface available transglutaminase substrate reactive groups in an amount sufficient to attach the microparticles to the body tissue in the presence of the transglutaminase, allowing the microparticles to remain in contact with the body tissue for a time sufficient to permit a layer of microparticles to covalently attach to the body tissue, wherein the transglutaminase substrate reactive groups are part of a polymer, and wherein the polymer comprises a polymer selected from the group consisting of polymers containing: (a) at least two contiguous linked lysines, (b) at least three contiguous linked lysines, (c) at least four contiguous linked lysines, and (d) at least five contiguous linked lysines. 15. The method of claim 14, wherein the polymer is a polymer containing at least two contiguous linked lysines.16. The method of claim 14, wherein the polymer is a polymer containing at least three contiguous linked lysines.17. The method of claim 14, wherein the polymer is a polymer containing at least four contiguous linked lysines.18. The method of claim 14, wherein the polymer is a polymer containing at least five contiguous linked lysines.19. The method of claim 14, wherein the endogenous or exogenous transglutaminase is endogenous transglutaminase.20. The method of claim 14, wherein the endogenous or exogenous transglutaminase is exogenous transglutaminase.21. The method of claim 14, wherein the body tissue is integument.22. The method of claim 21, wherein the integument is skin.23. The method of claim 21, wherein the integument is the surface of the eye.24. The method of claim 21, wherein the integument is a mucous membrane.25. The method of claim 14, wherein the body tissue is an internal tissue.26. The method of claim 14, wherein the microparticles further comprise an active agent.27. A method of treating a subject to attach microparticles to a body tissue of the subject comprisingcontacting the body tissue in the presence of endogenous or exogenous transglutaminase with microparticles having surface available transglutaminase substrate reactive groups in an amount sufficient to attach the microparticles to the body tissue in the presence of the transglutaminase, allowing the microparticles to remain in contact with the body tissue for a time sufficient to permit a layer of microparticles to covalently attach to the body tissue, wherein the transglutaminase substrate reactive groups are part of a polymer, and wherein the polymer comprises a polymer selected from the group consisting of polymers containing: (a) at least five contiguous linked glutamines, (b) at least ten contiguous linked glutamines, (c) at least fifteen contiguous linked glutamines, and (d) at least twenty contiguous linked glutamines. 28. The method of claim 27, wherein the polymer is a polymer containing at least five contiguous linked glutamines.29. The method of claim 27, wherein the polymer is a polymer containing at least ten contiguous linked glutamines.30. The method of claim 27, wherein the polymer is a polymer containing at least fifteen contiguous linked glutamines.31. The method of claim 27, wherein the polymer is a polymer containing at least twenty contiguous linked glutamines.32. The method of claim 27, wherein the endogenous or exogenous transglutaminase is endogenous transglutaminase.33. The method of claim 27, wherein the endogenous or exogenous transglutaminase is exogenous transglutaminase.34. The method of claim 24, wherein the body tissue is integument.35. The method of claim 34, wherein the integument is skin.36. The method of claim 34, wherein the integument is the surface of the eye.37. The method of claim 34, wherein the integument is a mucous membrane.38. The method of claim 27, wherein the body tissue is an internal tissue.39. The method of claim 27, wherein the microparticles further comprise an active agent.
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이 특허에 인용된 특허 (281)
Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), 2′,5′-phosphorothioate oligoadenylates and their covalent conjugates with polylysine.
Shen Wei C. (145 Richdale Rd. Needham MA 02194) Ryser Hugues J. (503 Annursnac Hill Rd. Concord MA 01742), Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers.
Edwards David A. ; Caponetti Giovanni,ITX ; Hrkach Jeffrey S. ; Lotan Noah,ILX ; Hanes Justin ; Ben-Jebria Abdell Aziz ; Langer Robert S., Aerodynamically light particles for pulmonary drug delivery.
Hayashi Akio (Osaka JPX) Hiramatsu Makoto (Osaka JPX) Hamanaka Nobuyuki (Osaka JPX), Antibodies for mevalonic acid and methods for immunological determination of mevalonic acid by using them.
Hayashi Akio (Osaka JPX) Hiramatsu Makoto (Osaka JPX) Hamanaka Nobuyuki (Osaka JPX), Antibodies for mevalonic acid and methods for immunological determination of mevalonic acid by using them.
Soranzo Carlo,ITX ; Abatangelo Giovanni,ITX ; Callegaro Lanfranco,ITX, Artificial skin containing as support biocompatible materials based on hyaluronic acid derivatives.
Green Howard ; Corey George D. ; Compton Bruce J. ; Dijan Philippe,FRX, Attaching agents to tissue with transglutaminase and a transglutaminase substrate.
Eichner Wolfram,DEX ; Kock Katharina,DEX ; Mielke Heiko,DEX ; Doerschner Albrecht,DEX, Cell adhesion peptides for modifying the adhesion capacity of eukaryotic cells between each other.
Farer Alan M. (Morganville NJ) Burdzy Elisa L. (Clifton NJ) Hanna Fifi (Kearny NJ) Penicnak A. John (Mountain Lakes NJ), Coated particle for use in cosmetic preparations and method.
Farer Alan M. (Morganville NJ) Hanna Fifi (Kearny NJ) Fox Elisa L. (Upper Montclair NJ) Penicnak A. John (Mountain Lakes NJ), Combination of hollow microspheres of a thermoplastic synthetic material, hexagonal boron nitride and N-acyl lysine as a.
Birnstiel Max L.,ATX ; Cotten Matthew,ATX ; Wagner Ernst,ATX, Complexes containing nucleic acid which can be taken-up by endocytosis into higher eukaryotic cells.
Grollier Jean F. (Paris FRX) Dubief Claude (Le Chesnay FRX), Composition and process for treating keratinic substances with at least one anionic polymer and at least one quaternized.
L. Wayne Schneider ; Daniel A. Gamache ; Lori K. Weimer ; Timothy L. Kessler ; Zhongyou Wei ; Terri Pasquine ; John M. Yanni ; Haresh G. Bhagat, Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders.
Curiel David T. (Chapel Hill NC) Hu Ping-chuan (Chapel Hill NC) Birnstiel Max L. (Vienna ATX) Cotten Matthew (Vienna ATX) Wagner Ernst (Langenzersdorf ATX), Conjugates for introducing nucleic acid into higher eucaryotic cells.
Lang Gerard (Saint-Gratien FRX) Malaval Alain (Marly-la-Ville FRX) Leduc Madeleine (Paris FRX), Cosmetic composition for protection against ultraviolet radiation and its use for this purpose.
Green Howard (82 Williston Rd. Brookline MA 02146) Dijan Philippe (18 ; rue Ferdinand Fabre 75015 Paris FRX), Cosmetic containing comeocyte proteins and transglutaminase, and method of application.
Richardson Norman K. (Rockaway NJ) Schilling Kurt M. (Parkgate NJ GB2) Pocalyko David J. (Lincoln Park NJ) Bailey Peter L. (Heswall GB3), Covalent bonding of active agents to skin, hair or nails.
Soon-Shiong Patrick ; Desai Neil P. ; Sandford Paul A. ; Heintz Roswitha A. ; Sojomihardjo Soebianto, Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release.
Hawkins Phillip R. (Mountain View CA) Wilde Craig G. (Sunnyvale CA) Seilhamer Jeffrey J. (Los Altos Hills CA), DNA encoding a hyaluronan receptor expressed in human umbilical vein endothelial cells.
Lasky Laurence A. (Sausalito CA) Rosen Steven D. (San Francisco CA) Stachel Scott E. (Berkeley CA) Singer Mark S. (Berkeley CA) Yednock Ted A. (Fairfax CA), DNA sequence encoding a functional domain of a lymphocyte homing receptor.
Goldin Stanley M. (Lexington MA) Mahanthappa Nagesh K. (Cambridge MA) Sudhalter Judith (Newton Lower Falls MA) Fine Eric (Lausanne CHX), Device for delivery of substances and methods of use thereof.
Huff Jeffrey B. (Park Ridge IL) Bieniarz Christopher (Highland Park IL) Horng Wayne J. (Glenview IL), Fluorescent polymer labeled conjugates and intermediates.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill-West Jennifer L. (Austin TX) Hossainy Syed F. A. (Austin TX), Gels for encapsulation of biological materials.
Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill Jennifer L. ; Hossainy Syed F. A., Gels for encapsulation of biological materials.
Desai Neil P. ; Soon-Shiong Patrick ; Sandford Paul A. ; Heintz Roswitha E., Graft copolymer of polycationic species and water-soluble polymers, and uses therefor.
Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha E. (Los Angeles CA), Graft copolymers of polycationic species and water-soluble polymers, and use therefor.
Buultjens Travis E. J. (Dundee GB6) Hellens Stephen W. (Dundee GB6) Jahoda Colin A. B. (Fife GB6) Oliver Roy F. (Fife GB6) Withers Anne P. (Dundee GB6), Hair growth composition.
Della Valle Francesco,ITX ; Lorenzi Silvana,ITX ; Cerini Roberto,ITX ; Marcolongo Gabriele,ITX, Highly bioadhesive and mucoadhesive compositions containing polyvinyl alcohol, polycarbophil and biopolymer for the tre.
Shimizu Fumio (Tokushima JPX) Tachikawa Tetsuya (Tokushima JPX) Ikei Nobuhiro (Tokushima JPX) Noda Atunari (Tokushima JPX) Hashimura Etsuro (Tokushima JPX) Imagawa Kenichi (Tokushima JPX), Human leukemia virus-related peptides, a process for production thereof, antibodies of the peptides and a process for pr.
della Valle Francesco,ITX ; Romeo Aurelio,ITX, Hyaluronic acid fractions having pharmaceutical activity, and pharmaceutical compositions containing the same.
Stern Robert ; Frost Gregory I. ; Csoka Anthony ; Wong Tim M., Hybridoma cell lines producing monoclonal antibodies that bind to human plasma hyaluronidase.
Pometto ; III Anthony L. (Boone IA) Demirci Ali (Ames IA) Johnson Kenneth E. (Ames IA), Immobilization of microorganisms on a support made of synthetic polymer and plant material.
Dickerson Kenneth T. (San Diego CA) Glass James R. (Cardiff CA) Liu Lin-Shu (Mountain View CA) Polarek James W. (Del Mar CA) Craig William S. (San Diego CA) Mullen Daniel G. (San Diego CA) Cheng Soan, Immobilization of peptides to hyaluronate.
Nacht Sergio ; Won Richard ; Katz Martin A. ; Cheng Tai ; Liau Christine J.Y. ; Eury Robert P. ; Froix Michael, Ionic beads useful for controlled release and adsorption.
Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha E. (Los Angeles CA), Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods.
Cohen Smadar (Petach-Tickya ILX) Bano Carmen (Valencia PA ESX) Visscher Karyn B. (State College PA) Chow Marie (Brookline MA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Ionically cross-linked polymeric microcapsules.
Macphee Colin Houston,GBX ; Tew David Graham,GBX ; Southan Christopher Donald,GBX ; Hickey Deirdre Mary Bernadette,GBX ; Gloger Israel Simon,GBX ; Lawrence Geoffrey Mark Prouse,GBX ; Rice Simon Quent, Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy.
Weiner Alan L. (Plainsboro NJ) Lenk Robert P. (Lambertville NJ) Carpenter-Green Sharon S. (Cranbury NJ) Fountain Michael W. (Plainsboro NJ), Localized delivery using fibronectin conjugates.
Evans Joan M. (Staten Island NY) Evans Gordon F. (Staten Island NY) Giffin Gregory C. (Martinsville NJ), Low sediment method for preparing copper salts of polyolefinic-substituted dicarboxylic acids.
Soon-Shiong Patrick ; Desai Neil P. ; Sandford Paul A. ; Heintz Roswitha A. ; Sojomihardjo Soebianto, Macrocapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor.
Schmitt-Willich Heribert,DEX ; Platzek Johannes,DEX ; Gries Heinz,DEX ; Schuhmann-Giampieri Gabriele,DEX ; Frenzel Thomas,DEX, Macrocyclic polymer complexing agents, their complexes, process for their production and pharmaceutical agents containin.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
Katz Robert ; Tomoaia-Cotisel Maria, Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-.
Hawkins Phillip R. ; Wilde Craig G. ; Seilhamer Jeffrey J., Method for detecting the presence of a polynucleotide encoding a hyaluronan receptor expressed in human umbilical vein endothelial cells.
de Weck Alain L. (14 ; Grand Places 1700 Fribourg CHX), Method for the determination of sulfidoleukotrienes in tissues and biological fluids and its application in diagnosis of.
Wu George Y. (Bloomfield CT) Wu Catherine H. (Bloomfield CT), Method for the introduction of genes into mammalian cells by a soluble molecular complex comprising a receptor ligand an.
Denis Alain (Loges FRX) Kieda Claudine (Orleans FRX) Monsigny Michel (Saint Cyr En Val FRX) Perrier Pierre (Orleans FRX) Redziniak Grard (Saint Cyr En Val FRX), Method of binding a product to the membrane of a keratinocyte by means of a ligand-receptor bond, method of preparing su.
Senyei Andrew E. (Chicago IL) Widder Kenneth J. (Chicago IL), Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres.
Abrahmsn Lars (Stockholm SEX) Moks Tomas (Taby SEX) Nilsson Bjrn (Sollentuna SEX) Uhln Mathias (Uppsala SEX), Method to export gene products to the growth medium of gram negative bacteria.
Flore Stephen G. ; Dellamary Luis A. ; Reeve Lorraine E. ; Weers Jeffry G., Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions.
Speaker Tully J. (Philadelphia PA) Sultzbaugh Kenneth J. (Philadelphia PA), Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses.
Soon-Shiong Patrick ; DeSai Neil P. ; Sandford Paul A. ; Heintz Roswitha A. ; Sojomihardjo Soebianto, Microcapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and use therefor.
Goldberg Eugene P. (Gainesville FL) Longo William E. (Gainesville FL) Iwata Hiroo (Suita JPX), Microspheres for incorporation of therapeutic substances and methods of preparation thereof.
Fischer Herbert (Dsseldorf DEX) Scheuermann Fanny (Dsseldorf DEX) Hase Christian (Erkrath DEX) Krause Horst-Jrgen (Dsseldorf DEX), Mild-to-the-skin anionic tensides of basic protein aminolysates preparations containing them, and their use.
Jiang Ying (North Haven CT) Gruskin Elliott A. (Killingworth CT), Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom.
Leopold Lance H. (Philadelphia PA) Shore Scott K. (Ardmore PA) Reddy Moole V. R. (Upper Darby PA) Reddy E. Premkumar (Villanova PA), Multi-unit ribozyme inhibition of oncogene gene expression.
Boutin Raymond H., Multifunctional complexes for gene transfer into cells comprising a nucleic acid bound to a polyamine and having a endosome disruption agent.
Raymond H. Boutin, Multifunctional complexes for gene transfer into cells comprising a nucleic acid bound to a polyamine and having an endosome disruption agent.
Hubbell Jeffrey A. ; Elbert Donald ; Hill-West Jennifer L. ; Drumheller Paul D. ; Chowdhury Sanghamitra ; Sawhney Amarpreet S., Multifunctional organic polymers.
Moeller Hinrich (Monheim DEX) Zeidler Ulrich (Duesseldorf DEX), Oligopeptide derivatives, their production and their use as surfactants gentle to the skin.
Sumner-Smith Martin (Bolton CAX) Barnett Richard W. (Mississauga CAX) Reid Lorne S. (Toronto CAX) Sonenberg Nahum (St. Luc CAX), Peptide-based inhibitors of HIV replication.
Page Raymond L. (Christiansburg VA) Velander William H. (Blacksburg VA) Johnson John L. (Blacksburg VA), Polyelectrolyte DNA conjugation and genetic transformation of an animal.
Mathiowitz Edith ; Jacob Jules S. ; Chickering ; III Donald E. ; Pekarek Kathleen Jo, Preparation of multiwall polymeric microcapsules from hydrophilic polymers.
Rosenthal Murray A. (Akron OH) Jackson Michael E. (Akron OH), Primary standard and method of making secondary standards for calibration of glycated protein assays.
Romeo Aurelio (Rome ITX) Lorenzi Silvana (Padua ITX), Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use.
Albert, Winfried; Ziegenhorn, Joachim; Siedel, Joachim; Batz, Hans-Georg; Lenz, Helmut; Pautz, Brigitte, Process and reagent for the determination of creatinine.
Morra Marco,ITX ; Cassinelli Clara,ITX ; Benedetti Luca,ITX ; Callegaro Lanfranco,ITX, Process for the coating of objects with hyaluronic acid, derivatives thereof, and semisynthetic polymers.
Brewer Stephen J. (High Wycombe GB2) Sassenfeld Helmut M. (Benson GB2), Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase.
Bommelaer Jean (Le Cannet FRX) Franco Andr (Menton FRX) Gueyne Jean (Monte Carlo MOX) Seguin Marie-Christine (Monte Carlo MOX), Products for cutaneous applications with cosmetic and/or therapeutic effects.
Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Mathiowitz Edith (Brookline MA) Schwaller Kirsten (Duxbury MA) Beck Thomas R. (Concord MA), Protein microspheres and methods of using them.
Dean Richard T. (Downingtown PA) Boutin Raymond H. (Wilmington DE) Lister-James John (Glenmoore PA), Proteins modified with positively charged carriers and compositions prepared therefrom.
Langer Robert S. ; Elisseeff Jennifer H. ; Anseth Kristi ; Sims Derek, Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering.
Fox Charles (39-08 Tierney Pl. Fairlawn NJ 07410) DeWitt John W. (9 Parker Ct. Florham Park NJ 07932) Rothenberger ; Jr. John D. (303 Parkside Rd. Harrington Park NJ 07640), Skin protein complexing composition for the potentiation of the substantivity of aluminum acetate through the use of a c.
Sutton Andrew D.,GBX ; Johnson Richard A.,GBX ; Senior Peter J.,GBX ; Heath David,GBX, Spray-dried microparticles and their use as therapeutic vehicles.
Grieco Paul A. ; Morre D. James ; Corbett Thomas H. ; Valeriote Frederick A., Therapeutic Quassinoid preparations with antineoplastic, antiviral, and herbistatic activity.
Peterson Robert V. (Murray UT) Anderson James M. (Cleveland Heights OH) Gregonis Donald E. (Salt Lake City UT) Kim Sunj-Wan (Salt Lake City UT) Feijen Jan (Hengelo NLX), Time-release chemical delivery system.
Twist ; deceased Michael (late of Toronto CAX by Harvey L. Hamburg ; Administrator ) Sumner-Smith Martin (Bolton CAX), Treatment of cytomegalovirus infection.
Beachey Edwin H. (Memphis TN), Type-specific opsonic antibodies evoked with a synthetic peptide of streptococcal M protein conjugated to polylysine wit.
Asculai Samuel S.,CAX ; Falk Rudolf E.,CAX ; Russell Alan L.,CAX, Use of hyaluronic acid and a NSAID for the manufacture of a medicament for the treatment of mucosal diseases.
Hill Nicholas S. ; Thompson ; Jr. Frederick N. ; Stuedemann John A. ; Dawe Donald L., Vaccines and methods for preventing and treating Fescue toxicosis in herbivores.
Russell-Jones Gregory J. (Middle Cove AUX) Westwood Steven W. (Ashfield AUX), Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions.
Cooper, Eugene Rex; Kleinman, David Maxwell; Loxley, Andrew; Mitchnick, Mark A., Bi-functional co-polymer use for ophthalmic and other topical and local applications.
Cooper, Eugene R.; Kleinman, David M.; Loxley, Andrew; Mitchnick, Mark, Bi-functional co-polymer use for opthalmic and other topical and local applications.
Bui, Hy Si; Tong, Anita Chon; Rossi, Maria Pia, Reaction product of a polar modified polymer and an alkoxysilane and a composition containing the reaction product.
Bui, Hy Si; Tong, Anita; Rossi, Maria Pia, Reaction product of a polar modified polymer and an alkoxysilane and a composition containing the reaction product.
Bui, Hy Si; Kanji, Mohamed; Li, Chunhua; Tong, Anita Chon; Halpern, Susan; Bavouzet, Bruno, Water-insoluble reaction product of a polyamine and an oil-soluble high carbon polar modified polymer.
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