Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-006/00
A61B-005/07
출원번호
US-0422120
(2003-04-24)
발명자
/ 주소
Scarantino, Charles W.
Nagle, H. Troy
Hall, Lester C.
Mueller, Jeffrey
출원인 / 주소
North Carolina State University
Sicel Techonologies, Inc.
대리인 / 주소
Myers Bigel Sibley &
인용정보
피인용 횟수 :
67인용 특허 :
126
초록▼
Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzin
Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.
대표청구항▼
1. A method for monitoring a patient undergoing treatment for cancer, comprising:positioning at least one wireless sensor in tissue in a region of interest in the body of a patient being treated for cancer; administering a therapeutic radiolabeled analyte to the patient; detecting in vivo from the a
1. A method for monitoring a patient undergoing treatment for cancer, comprising:positioning at least one wireless sensor in tissue in a region of interest in the body of a patient being treated for cancer; administering a therapeutic radiolabeled analyte to the patient; detecting in vivo from the at least one sensor a signal corresponding to radiation in the region of interest in the patient responsive to the administering step; relaying the signal to a location external of the patient's body; and monitoring the signal over time to determine the localized response of the patient to the administered analyte to provide patient-specific response data that can be used to develop a patient specific cancer treatment strategy and/or evaluate the clinical efficacy of the treatment in the patient. 2. A method according to claim 1, wherein the therapeutic radiolabeled analyte is a beta labeled analyte.3. A method according to claim 2, further comprising determining drug uptake and/or utilization based on the monitored signal response data.4. A method according to claim 2, further comprising evaluating blood flow proximate to, on and/or in a tumor in the localized region based on said monitored signal response data.5. A method according to claim 2, further comprising evaluating the patient's sensitivity to at least one selected cancer therapeutic drug based on said monitored signal response data.6. A method according to claim 2, further comprising determining drug distribution in a localized region in the patient based on said monitored signal response data.7. A method according to claim 2, wherein the localized region is a cancerous tumor, and wherein said method further comprises determining cancer cell sensitivity or receptiveness to a predetermined therapeutic drug treatment in the tumor.8. A method according to claim 2, wherein the patient is a human subject, and wherein the localized region comprises a tumor treatment site, said method further comprising determining a dose of radiation delivered to the tumor treatment site by the radiolabeled analyte based on said monitoring step.9. A method according to claim 2, wherein said sensor is positioned spatially proximate to a tumor in the patient, and wherein said administering step is first carried out at a time which is proximate to a first planned therapeutic treatment, and wherein said detecting step further comprises determining if the tumor is likely to be responsive to the planned treatment based on said detecting and monitoring steps.10. A method according to claim 2, further comprising selecting a pharmaceutical therapeutic treatment drug based on said monitoring step.11. A method according to claim 1, further comprising evaluating cell proliferation proximate to and/or in a tumor treatment site based on said monitored signal response data.12. A method according to claim 1, further comprising generating a predictive treatment outcome based on the monitored response data.13. A method according to claim 1, wherein the monitoring step is carried out in substantially real time.14. A method according to claim 1, further comprising excluding certain types of treatment as being unlikely to be clinically effective based on the response data obtained by said monitoring step.15. A method according to claim 1, wherein the step of positioning is carried out so that at least one sensor is positioned in the body such that it resides proximate to, on and/or in a cancerous tumor.16. A method according to claim 15, wherein the step of positioning is carried out so that the sensor is chronically implanted in the subject.17. A method according to claim 16, wherein the sensor is a unitary body implantable sensor configured to detect radiation in at least one of a direct or indirect mode of detection and wirelessly communicate the detected radiation data to an externally located reader.18. A method according to claim 15, wherein the sensor includes a sensor probe body connected to and spaced apart from a processor body, and wherein the step of positioning comprises implanting the sensor probe body at a first location proximate to or in the tumor site so that it can detect radiation in a direct and/or indirect radiation detection mode and implanting the processor body at a second subcutaneous location proximate normal tissue, the second location being spaced apart from the first location.19. A method according to claim 1, wherein said at least one sensor is a plurality of sensors configured to detect the emitted radiation from the radiolabeled analyte at a plurality of different locations in vivo within the region of interest.20. A method according to claim 19, wherein the step of positioning is carried out so that at least one sensor is positioned proximate to cancerous tissue and another sensor is positioned proximate to normal tissue, and wherein said detecting step detects the radiation corresponding to the sensors located proximate to both normal and cancerous tissue.21. A method according to claim 1, wherein said monitoring step determines cell sensitivity or receptiveness to uptake and/or retention of at least one of a selected group of chemotherapeutic agents.22. A method according to claim 1, wherein said monitoring step is carried out such that the radiation in the region of interest is monitored at least periodically over a period of time extending for at least between about 0.25-48 hours proximate in time to each of a plurality of planned and/or delivered therapeutic treatments.23. A method according to claim 22, wherein said administering step is carried out proximate in time to a planned therapeutic treatment, and wherein based on said detecting and monitoring steps, a clinician selects at least one of (a) a suitable chemotherapy treatment and (b) a treatment time.24. A detection system for detecting radiation emitted from an internally administered radiolabeled analyte, comprising:at least one wireless implanted radiation sensor contigtzred for in vivo operation, the at least one sensor being configured to directly and/or indirectly detect beta radiation from an internally administered beta radiolabeled analyte proximate to a targeted cancer treatment site in the body, wherein the at least one sensor is configured to detect, at least intermittently, over a period of desired time; and an external reader operably associated with the at least one radiation sensor and configured to receive signal data associated with the direct and/or indirectly detected radiation from the at least one sensor, wherein said system is configured to dynamically monitor selected in vivo parameters associated with one or more of the dose, uptake and/or processing of the radiation from the internally administered radiolabeled analyte at the targeted cancer treatment site. 25. A system according to claim 24, wherein the sensor is configured as a chronically implanted sensor configured for at least one of direct or indirect detection of radiation and adapted to reside on and/or in a tumor at any depth in the body of a subject.26. A system according to claim 24, wherein the at least one sensor is configured to wirelessly transmit signals associated with the in vivo detected radiation over a plurality of monitoring periods during a treatment regime extending from between about 1 week-3 months.27. A system according to claim 24, wherein the internally administered radiolabeled analyte comprises a therapeutic radiolabled analyte, wherein the at least one sensor is configured to detect radiation from the therapeutic radiolabled analyte and wirelessly transmit signals associated with the in vivo detected radiation at desired spaced apart monitoring intervals corresponding to a plurality of different treatment sessions that are delivered over at least about a one month time period.28. A system according to claim 24, wherein the at least one sensor is a plurality of sensors, including first and second sensors that are adapted to detect radiation emitted from respective first and second spatially separate locations in the target treatment site.29. A system according to claim 24, wherein the at least one sensor is a plurality of sensors configured to be individually operable.30. A system according to claim 29, wherein the plurality of sensors includes a first sensor adapted to be held at a first location associated with normal or non-diseased tissue, and a second sensor adapted to be held at a second location associated with excised, diseased, abnormal, and/or cancerous tissue.31. A computer program product for evaluating radiation dose received at a target treatment site from a radiolabeled analyte administered in response to a cancer treatment regimen, said computer program product comprising:computer readable program code for receiving a plurality of measurements of radiation detected in vivo in tissue from a chronically implanted sensor located about a local targeted cancer treatment site in the body of a human subject undergoing treatment for cancer, the detected radiation corresponding to radiation emitted from a selected beta radiolabeled analyte administered internally to the subject; and computer readable program code for computing one or more of a patient specific in vivo radiation dose, uptake, or processing of the radiolabeled analyte received at a cancer treatment site in a human subject based on the plurality of received measurements. 32. A computer program product according to claim 31, wherein the computer code for computing the dose is adapted to determine a patient-specific radiation dose received at a primary tumor site and at least one metastatic site.33. A computer program product according to claim 31, further comprising computer readable program code for initiating operation of at least one implanted telemetric sensor proximate in time to each of a plurality of therapy sessions to obtain a plurality of discrete doses administered at temporally different points in time.34. A computer program product according to claim 33, wherein further comprising computer program code for calculating a cumulative dose received at the target treatment site corresponding to a plurality of separate administered therapeutic doses of radiolabeled analytes.35. A computer program product according to claim 33, further comprising computer readable program code for individually operating a plurality of telemetrically operable implanted sensors held in the subject to assess the amount of internal radiation received at a plurality of different sites.36. A computer program product according to claim 35, wherein said computer program product includes computer program code for initiating the receipt of the measurements from a plurality of different sensors so as to wirelessly obtain a plurality of measurements from different sites, at least one in non-targeted treatment tissue and at least one in the target cancer treatment site, in the body over an active treatment period extending over a plurality of temporally spaced apart treatment sessions.37. A computer program product according to claim 31, wherein the radiolabeled analyte is a therapeutic radiolabeled analyte, and wherein the computer readable program code for computing comprises computer readable program code for monitoring the uptake and utilization of the internally administered radiolabeled analyte at the cancer treatment site over a desired monitoring period.38. A method for monitoring a patient undergoing treatment for cancer, comprising:positioning at least one wireless sensor in tissue in a region of interest in the body of a patient being treated for cancer; administering a therapeutic radioactive analyte internally to the patient; detecting in vivo from the at least one sensor a signal corresponding to radiation in the region of interest in the patient responsive to the administering step; relaying the signal to a location external of the patient's body; and monitoring the signal over time to determine the localized response of the patient to the administered analyte to provide patient-specific response data that can be used to develop a patient specific cancer treatment strategy and/or evaluate the clinical efficacy of the treatment in the patient. 39. A method according to claim 38, further comprising determining radiation dose, uptake and/or utilization based on the monitored signal response data.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (126)
Eyal Doron IL; Avi Penner IL, Acoustic biosensor for monitoring physiological conditions in a body implantation site.
Halleck Michael D. (Northglenn CO) James Donald N. (Estes Park CO) Halleck Michael E. (Longmont CO), Apparatus and method for remote monitoring of physiological parameters.
Sperinde Johnie M. (San Jose CA) Goldring Stanley D. (Cupertino CA) Miller Dean T. (Portola Valley CA), Apparatus for determining oxygen saturation levels in blood.
Cox Timothy J. (Lake Jackson TX) Armstrong Randolph K. (Missouri City TX), Apparatus for high speed data communication between an external medical device and an implantable medical device.
Policastro Charles J. (2122 Old Forde Way Lansdale PA 19446) Dougherty Edmond J. (Philadelphia PA) Dowling Martin J. (Haddonfield NJ), Apparatus for monitoring, storing and transmitting detected physiological information.
Fenzlein Paul-Gerhard (Elsa-Brandstrmstrasse 33 D-8500 Nrnberg 80 DEX) Anderer Wolfgang (Aurachtal DEX), Apparatus for the determination of medical, electro-chemical measured values relevant to organic or metabolic functions.
Harrison Michael R. (San Francisco CA) Jennings Russell W. (Pacifica CA), B\method for monitoring fetal characteristics by radiotelemetric transmission.
Steffel Charles R. (Munroe Falls OH) Taylor Bruce C. (Kent OH), Circuit and method for the radiotelemetry of esophageal pH in an ECG radiotelemetry system.
Gough David A. (Cardiff CA) Lucisano Joseph Y. (La Jolla CA) Armour Jon C. (La Jolla CA) McKean Brian D. (San Diego CA), Complete glucose monitoring system with an implantable, telemetered sensor module.
Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
Brockway Brian P. (Minneapolis MN) Mills Perry A. (Roseville MN) Miller Jonathan T. (St. Paul MN), Device for chronic measurement of internal body pressure.
Schulman Joseph H. (Santa Clarita CA) Rule ; III Orville R. (Los Angeles CA) Whitmoyer David I. (Los Angeles CA) Lebel Ronald J. (Sherman Oaks CA) Lucisano Joseph Y. (Saugus CA) Mann Alfred E. (Bever, Glucose monitoring system.
Halperin Louis E. (St. Paul MN) Lee Brian B. (Golden Valley MN) Roline Glenn M. (Anoka MN) Varrichio Anthony J. (Flanders NJ), Implantable capacitive absolute pressure and temperature monitor system.
Halperin Louis E. (St. Paul MN) Miesel Keith A. (St. Paul MN) Ufford Keith A. (Chisago City MN) Svensk James R. (Coon Rapids MN) Patrick Timothy (South St. Paul MN) Hassler Beth A. (White Bear Lake M, Implantable capacitive absolute pressure and temperature sensor.
Larson ; Jr. Carl O. ; Smith James S. ; Chapman John H. ; Slimon Scot A. ; Trahan John D. ; Brozek Robert J. ; Franco Alberto ; McGarvey John J. ; Rosen Marvin E. ; Pasque Michael K., Implantable device monitoring arrangement and method.
Bessman Samuel P. (2025 Zonal Ave. Los Angeles CA 90033) Layne Ennis C. (9128 Huntington Dr. San Gabriel CA 91775) Thomas Lyell J. (1900 Pelican Ave. San Pedro CA 90732), Implantable glucose sensor.
Marchosky Jose A. (Creve Couer MO) Alek Robert B. (Ellisville MO) Moran Christopher (Creve Coeur MO) Rutledge Raymond E. (Ballwin MO), Implantable hyperthermia device and system.
Prutchi David (Lake Jackson TX) Paul Patrick J. (Lake Jackson TX), Implantable medical device with enclosed physiological parameter sensors or telemetry link.
Loeb Gerald E. (90 Bagot Street Kingston ; Ontario CAX K7L 3E5 ) Schulman Joseph H. (10650 Comet Way Santa Clarita CA 91351), Implantable multichannel stimulator.
Mazziotta John C. (Beverly Hills CA) Daghighian Farhad (New York NY) Hoffman Edward J. (Van Nuys CA), Intraoperative beta probe and method of using the same.
Bergstrom Inga-Maria (Stockholm SEX) Bergstrom Mats-Johan M. (Stockholm SEX) Nilsson Kenth (Akersberga SEX), Medical field detector and telemetry unit for implants.
Markowitz Raymond S. (Elkins Park PA) Roy Robert E. (Herndon VA) Sun Xiaoguang G. (King of Prussia PA), Medical telemetry system using an implanted passive transponder.
Duffy Peter H. (Pine Bluff AR) Meehan ; III Joseph F. (Little Rock AR) Hart Ronald W. (Little Rock AR), Method and apparatus for assessing metabolic behavioral and physiological status of animals.
Marchosky J. Alexander (1501 Cerulean Dr. Creve Coeur MO 63146) Moran Christopher J. (12559 Amersham Ct. Town and Country MO 63141) Fearnot Neal E. (832 Ashland St. West Lafayette IN 47906), Method and apparatus for volumetric interstitial conductive hyperthermia.
Marchosky J. Alexander (Creve Coeur MO) Moran Christopher J. (Town and Country MO) Fearnot Neal E. (West Lafayette IN), Method and apparatus for volumetric interstitial conductive hyperthermia.
Abraham-Fuchs Klaus,DEX ; Gumbrecht Walter,DEX ; Hierold Christofer,DEX ; Scheiter Thomas,DEX, Method for manufacturing a combination of a pressure sensor and an electrochemical sensor.
Rumbaugh Scott H. (Lake Oswego OR) Davidson Andrew C. (Portland OR), Method for measuring the electrical and optical performance of on-wafer microwave devices.
Tarr Nicholas Garry,CAX ; Thomson Ian,CAX, Method of monitoring radiation using a floating gate field effect transistor dosimeter, and dosimeter for use therein.
Marchosky Jose A. (Creve Couer MO) Moran Christopher J. (St. Louis MO) Fearnot Neal E. (West Lafayette IN), Method, apparatus, and substance for treating tissue having neoplastic cells.
Huffman Dennis D. (Albuquerque NM) Hughes Robert C. (Albuquerque NM) Kelsey Charles A. (Albuquerque NM) Lane Richard (Galveston TX) Ricco Antonio J. (Albuquerque NM) Snelling Jay B. (Albuquerque NM) , Methods of in vivo radiation measurement.
Lefkowitz Steven M. (Walnut Creek CA) Leugers Mary A. (Midland MI) Brownell Steven J. (Midland MI) Helmer Deborah C. (Midland MI) Kastl Patrick E. (Midland MI) Chrisman Ray (Midland MI) Langvardt Pat, Miniaturized sensor for ionizing radiation.
McNulty Peter J. (Sseneca SC) Beauvais W. Joseph (Central SC) Roth David R. (Pendleton SC) Moran Wanda K. (Phoenix AZ) Reed Robert A. (Clemson SC), Passive solid state microdosimeter with electronic readout.
Synjkangas Seppo (Kykkyrintie 20 90440 Kempele FIX), Procedure and means for telemetric measuring of heartbeat and ECG signal, using a magnetic proximity field.
Thomas Edward V. (Albuquerque NM) Robinson Mark R. (Albuquerque NM) Haaland David M. (Albuquerque NM) Alam Mary K. (Albuquerque NM), Reliable noninvasive measurement of blood gases.
Thomas Edward V. (Albuquerque NM) Robinson Mark R. (Albuquerque NM) Haaland David M. (Albuquerque NM) Alam Mary K. (Cedar Crest NM), Reliable noninvasive measurement of blood gases.
Alfano Robert R. ; Alfano Scott ; Wang Quan-Zhen ; Ho Ping Pei, Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment.
Morgan Wayne A. (Granada Hills CA) Mann Brian M. (Beverly Hills CA), System and method for measuring and storing parametric data pertaining to operating characteristics of an implantable me.
Mueller Jeffrey S. ; Nagle H. Troy ; Gyurcsik Ronald S. ; Kelley Arthur W., System and method for powering, controlling, and communicating with multiple inductively-powered devices.
Bryan Avron I. (26 Country Club Rd. Cocoa Beach FL 32931) Cushman Michael R. (521 Brandonwood Rd. Kingsport TN 37662), System for monitoring and reporting the operability and calibration status of a dissolved oxygen sensor.
Wyborny Paul B. (Fridley MN) Roline Glenn M. (Anoka MN) Nichols Lucy M. (Maple Grove MN) Thompson David L. (Fridley MN), Telemetry format for implanted medical device.
Wyborny Paul B. (Coon Rapids MN) Roline Glenn M. (Anoka MN) Nichols Lucy M. (Maple Grove MN) Thompson David L. (Fridley MN), Telemetry system for an implantable medical device.
Badger Christopher W. (Champaign IL) Burdette Everette C. (Champaign IL) Leech Steven C. (Tinton Falls NJ) McCarthy John F. (Champaign IL), Temperature control and analysis system for hyperthermia treatment.
Hardy Tyrone L. (Albuquerque NM) Brynildson Laura D. (Albuquerque NM), Three-dimensional beam localization apparatus and microscope for stereotactic diagnoses or surgery mounted on robotic ty.
Rousso, Benny; Ben-Haim, Shlomo; Melman, Haim; Bronshtine, Zohar; Zilberstien, Yoel; Nagler, Michael; Dickman, Dalia; Omer, Einav, Imaging system customization using data from radiopharmaceutical-associated data carrier.
DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
Verhoef, Erik T.; DiPerna, Paul M.; Rosinko, Mike; Williamson, Mark; Kruse, Geoffrey A.; Ulrich, Thomas R.; Lamb, Phil; Saint, Sean; Michaud, Michael; Trevaskis, William, Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
Meier, Eric; Mate, Timothy P.; Wright, J. Nelson; Dimmer, Steven C.; Purdy, Lynn M., Integrated radiation therapy systems and methods for treating a target in a patient.
Meier, Eric; Mate, Timothy P.; Wright, J. Nelson; Dimmer, Steven C.; Purdy, Lynn M., Integrated radiation therapy systems and methods for treating a target in a patient.
Meier, Eric; Mate, Timothy P.; Wright, J. Nelson; Dimmer, Steven C.; Purdy, Lynn M., Integrated radiation therapy systems and methods for treating a target in a patient.
Ben-David, Gal; Zilberstien, Yoel; Kimchy, Yoav, Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures.
David, Gal Ben; Zilberstien, Yoel; Kimchy, Yoav; Amrani, Roni, Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures.
Kimchy, Yoav; Amrami, Roni; Bouskila, Yona; Antebi, Udi; Sidorenko, Nick; Ben-David, Gal; Zilberstein, Yoel, Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.