Synthetic implant with nonimmunogenicity coating
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
A61F-002/06
A61F-002/12
A61F-002/24
A61F-002/76
A61M-005/00
A61M-025/00
출원번호
US-0766146
(2004-01-27)
발명자
/ 주소
Rhee, Woonza M.
DeLustro, Frank A.
Berg, Richard A.
출원인 / 주소
Cohesion Technologies, Inc.
대리인 / 주소
Reed Intellectual Property Law Group
인용정보
피인용 횟수 :
26인용 특허 :
118
초록▼
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gl
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (?NH2) or thiol (?SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.
대표청구항▼
1. A method for providing a biocompatible, nonimmunogenic coating on the surface of a synthetic implant, comprising:(a) providing a first crosslinkable component having m nucleophilic groups, wherein m?2; (b) providing a second crosslinkable component having n electrophilic groups capable of reactio
1. A method for providing a biocompatible, nonimmunogenic coating on the surface of a synthetic implant, comprising:(a) providing a first crosslinkable component having m nucleophilic groups, wherein m?2; (b) providing a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n?2 and m+n?5; (c) applying the first and second crosslinkable components to a surface of a synthetic implant to provide a coating thereon; and (d) allowing the components to crosslink in situ to provide a synthetic implant coated with a biocompatible, nonimmunogenic composition, wherein the first and second crosslinkable components are biocompatible, synthetic, and nonimmunogenic. 2. The method of claim 1, wherein step (c) comprises simultaneously applying the first and second crosslinkable components to the surface of the synthetic implant to provide a coating thereon.3. The method of claim 2, wherein prior to step (c), the first and second crosslinkable components are admixed to provide a reaction mixture and initiate crosslinking, and step (c) comprises applying the reaction mixture to the surface of the synthetic implant to provide a coating thereon.4. The method of claim 3, wherein the reaction mixture has a net neutral charge.5. The method of claim 1, wherein the synthetic implant is an artificial blood vessel, a heart valve, a vascular graft, a vascular stent, or a vascular graft/stent combination.6. The method of claim 1, wherein the synthetic implant is an implantable surgical membrane.7. The method of claim 6, wherein the implantable surgical membrane is monofilament polypropylene.8. The method of claim 6, wherein the implantable surgical membrane is a mesh for use in hernia repair.9. The method of claim 1, wherein the synthetic implant is a breast implant.10. The method of claim 1, wherein the synthetic implant is a lenticule.11. The method of claim 1, wherein the m nucleophilic groups in the first crosslinkable component are identical.12. The method of claim 1, wherein at least two of the m nucleophilic groups in the first crosslinkable component are different.13. The method of claim 1, wherein the n electrophilic groups in the second crosslinkable component are identical.14. The method of claim 11, wherein the n electrophilic groups in the second crosslinkable component are identical.15. The method of claim 12, wherein the n electrophilic groups in the second crosslinkable component are identical.16. The method of claim 1, wherein the n electrophilic groups in the second crosslinkable component are different.17. The method of claim 11, wherein at least two of the n electrophilic groups in the second crosslinkable component are different.18. The method of claim 12, wherein at least two of the n electrophilic groups in the second crosslinkable component are different.19. The method of claim 1, wherein the m nucleophilic groups are bound to the first crosslinkable component through linking groups.20. The method of claim 1, wherein the n nucleophilic groups are bound to the second crosslinkable component through linking groups.21. The method of claim 1, wherein at least one of the first and second crosslinkable components is comprised of a hydrophilic polymer.22. The method of claim 1, wherein at least one of the first and second crosslinkable components is comprised of a hydrophobic polymer.23. The method of claim 1, wherein the m nucleophilic groups are primary amino groups.24. The method of claim 23, wherein the first crosslinkable component is C2-C6 hydrocarbyl susbstituted with amino groups.25. The method of claim 23, wherein the first crosslinkable component is a secondary or tertiary amine NR1R2R3 wherein R1 is hydrogen or an amino-substituted lower alkyl group, and R2 and R3 are amino-substituted lower alkyl groups.26. The method of claim 23, wherein the n electrophilic groups are selected from the group consisting of succinimidyl ester, sulfosuccinimidyl ester, maleimido, epoxy, isocyanato, thioisocyanato, and ethenesulfonyl.27. The method of claim 26, wherein the n electrophilic groups are selected from the group consisting of succinimidyl ester and sulfosuccinimidyl ester.28. The method of claim 1, wherein the m nucleophilic groups are sulfhydryl groups.29. The method of claim 28, wherein the n electrophilic groups are sulfhydryl-reactive groups selected so as to form a thioester, thioether, or disulfide linkage upon reaction with the sulfhydryl groups.30. The method of claim 1, wherein n=2.31. The method of claim 1, wherein m=2.32. The method of claim 1, wherein the crosslinking conditions comprise admixture in an aqueous medium.33. The method of claim 32, wherein the first and second crosslinkable components each represent about 0.5 wt. % to about 20 wt. % of the composition formed upon admixture.34. The method of claim 32, wherein the crosslinking conditions further comprise admixture at a pH in the range of 7 to 8.35. The method of claim 34, wherein the first and second crosslinkable components are at concentrations of 20 mg/mL to 200 mg/mL of the composition formed upon admixture.36. The method of claim 1, wherein the first crosslinkable component is in an aqueous solution, the second crosslinkable component is in dry, particulate form, and admixing comprises combining the second crosslinkable component with the aqueous solution of the first crosslinkable component.37. The method of claim 36, wherein the first and second crosslinkable components each represent about 0.5 wt % to about 20 wt. % of the composition formed upon admixture.38. The method of claim 36, wherein the crosslinking conditions further comprise admixture at a pH in the range of 7 to 8.39. The method of claim 38, wherein the first and second crosslinkable components are at concentrations of 20 mg/mL to 200 mg/mL of the composition formed upon admixture.40. The method of claim 1, wherein the first crosslinkable component is present in a molar excess relative to the second crosslinkable component.41. The method of claim 1, wherein the second crosslinkable component is present in a molar excess relative to the first crosslinkable component.42. A synthetic implant coated according to the method of claim 1.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (118)
Zalipsky Shmuel (Edison NJ), Active carbonates of polyalkylene oxides for modification of polypeptides.
Yeung Jeffrey E. (San Jose CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Rhee Woonza M. (Palo Alto CA), Anti-adhesion films and compositions for medical use.
Silver Frederick A. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Birk David E. (Somerset NJ) Weadock Kevin (Piscataway NJ) Whyne Conrad (Somerset NJ), Biodegradable matrix and methods for producing same.
Siiman Olavi (Davie FL) Burshteyn Alexander (Miami Lakes FL) Gupta Ravinder K. (Pembroke Pines FL), Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes f.
Juergensen Kay (Murten CHX) Aeschlimann Daniel (Basel CHX) Hunziker Ernst B. (Riedholz CHX), Biological adhesive composition and method of promoting adhesion between tissue surfaces.
Kelman Charles D. (New York NY) DeVore Dale P. (Chelmsford MA), Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom.
Kelman Charles D. (New York NY) Devore Dale P. (Chelmsford MA), Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Deibig Heinrich (Frankfurt am Main Schwalbach DEX) Heide Helmut (Schwalbach DEX) Reiner Roland (Eschborn DEX) Koster Kari (Lorsbach DEX), Bone replacement or prosthesis anchoring material.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA), Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications.
Miyata Teruo (Tokyo NJ JPX) Rubin Albert L. (Englewood NJ) Stenzel Kurt H. (Englewood NJ) Dunn Michael W. (New Rochelle NY), Collagen drug delivery device.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Harner Carol F. H. (Redwood Shores CA) Sakai Naomi (San Mateo CA) Schroeder Jacqu, Collagen-based bioadhesive compositions.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Stol Miroslav (Prague CSX) Tolar Miroslav (Prague CSX) Adam Milan (Prague CSX) Cefelin Pavel (Prague CSX) Kalal Jaroslav (Prague CSX), Composite polymeric material for biological and medical application and the method for its preparation.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Composition for bone repair.
Palefsky Howard (Atherton CA) Pharriss Bruce B. (Palo Alto CA) Chu George (Cupertino CA), Composition of low type III content human placental collagen.
Shadle Paula J. (Richmond CA) Koths Kirston E. (El Cerrito CA) Moreland Margaret (Berkeley CA) Katre Nandini (El Cerrito CA), Conjugation of polymer to colony stimulating factor-1.
Braatz James A. (Rockville MD) Kehr Clifton L. (Silver Spring MD), Contact lenses based on biocompatible polyurethane and polyurea-urethane hydrated polymers.
Soon-Shiong Patrick (Los Angeles CA) Desai Neil P. (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha A. (Los Angeles CA) Sojomihardjo Soebianto (Pasadena CA), Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Method of augmenting tissue with collagen-polymer conjugates.
Mosbach Klaus H. (Furulund SEX) Nilsson Kurt G. I. (Lund SEX), Method of covalently binding biologically active organic substances to polymeric substances.
Nesburn Anthony B. (Malibu CA) Gorin Michael (Rockville MD) Martinez Marvin (Glendale CA) Kenney M. Cristina (Malibu CA) Maguen Ezra (Los Angeles CA), Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers.
Franz Helmut (Biberach DEX) Muller Thomas (Biberach DEX) Eisert Wolfgang (Biberach DEX), Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydrox.
Wallace Donald G. (Menlo Park CA) Smestad Thomas L. (Palo Alto CA) McPherson John M. (Sunnyvale CA) Piez Karl A. (Menlo Park CA) Seyedin Saeid (Sunnyvale CA) Armstrong Rosa (Palo Alto CA), Methods of bone repair using collagen.
Cioca Gheorge (Coatesville PA) Feeley George F. (Downingtown PA) Brabson Joseph B. (Wilmington DE) Barth Peter (Neuwied DEX), Moisture vapor permeable sheet materials.
Luck Edward E. (216 Robin Way Menlo Park CA 94025) Daniels John R. (842 Las Casas Pacific Palisades CA 90272), Non-antigenic collagen and articles of manufacture.
Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
Daniels John R. (Menlo Park CA) Knapp Terry R. (Santa Clara CA), Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Schroeder Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA) F, Process for preparing a sterile, dry crosslinking agent.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Lido Beach NY) Eaton Alexander M. (New York NY), Tissue bonding and sealing composition and method of using the same.
Devore Dale P. (Chelmsford MA) Scherrer Robert A. (White Bear Lake MN) Scholz Matthew T. (Woodbury MN), Viscoelastic collagen solution for opthalmic use and method of preparation.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Palo Alto CA), Xenogeneic collagen/mineral preparations in bone repair.
Hippensteel, Gregory M.; Peek, Lawrence F.; Anderson, Jeffrey P.; Gorhe, Devendra; Allen, Steve M., Method for bonding a tantalum structure to a cobalt-alloy substrate.
Hippensteel, Gregory M.; Peek, Lawrence F.; Anderson, Jeffrey P.; Gorhe, Devendra; Allen, Steve M.; Scrafton, Joel G.; Harmon, Casey, Method for bonding a tantalum structure to a cobalt-alloy substrate.
Zhang, Kai; Buehler, Daniel; Brinkerhuff, Hallie E.; Hawkins, Michael E.; Klabunde, Ralf, Spacer with a coating thereon for use with an implant device.
Hussain, Ali; Cahalan, Linda; Johnson, Greg; Gartner, Mark; Cahalan, Patrick; Fill, Brian J; Speakman, Jeffrey W., Surface treated staples, sutures and dental floss and methods of manufacturing the same.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.