[특허]Durable multi-component antibiotic formulation for topical use

[미국특허] Durable multi-component antibiotic formulation for topical use 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A01N-025/24
출원번호	US-0208199 (2002-07-31)
발명자 / 주소	Askill, Ian N.
출원인 / 주소	MedLogic Global Limited
대리인 / 주소	Foley &
인용정보	피인용 횟수 : 16 인용 특허 : 10

초록

Disclosed are methods and formulations for the treatment or prevention of infections on mammalian tissues such as skin. Specifically, the methods of this invention involve the in situ formation of a polymeric cyanoacrylate film containing mixed antibiotics over mammalian tissue.

대표청구항 ▼

1. A polymerizable film-forming cyanoacrylate composition comprising:from about 50 to 99 weight percent of a polymerizable cyanoacrylate ester based on the total weight of the composition; an antibacterially effective amount of an antibiotic or a mixture of antibiotics which are insoluble in the polymerizable cyanoacrylate ester; and a sufficient amount of a thickening agent which forms a stable suspension or gel in combination with the cyanoacrylate ester and the antibiotic or the mixture of antibiotics, wherein at least 50% of the suspended material remains in suspension for a period of at least 3 months at 20° C. 2. The polymerizable film-forming cyanoacrylate composition according to claim 1, wherein said composition is characterized as possessing thixotropic properties.3. The polymerizable film-forming cyanoacrylate composition according to claim 2, wherein at least 50% of the suspended material remains in suspension for a period of at least 6 months.4. The polymerizable film-forming cyanoacrylate composition according to claim 3, wherein at least 90% of the suspended material remains in suspension for a period of at least 6 months.5. The polymerizable film-forming cyanoacrylate composition according to claim 1, wherein a mixture of antibiotics is employed in said composition to provide a spectrum of antibacterial activity.6. The polymerizable film-forming cyanoacrylate composition according to claim 1, wherein said mixture of antibiotics comprises neomycin, polymixin B sulfate, and bacitracin.7. The composition according to claim 1, wherein said polymerizable cyanoacrylate ester composition comprises a cyanoacrylate ester, which in monomeric form, is represented by formula I: where R is selected from the group consisting of: alkyl of 1 to 10 carbon atoms, alkenyl of 2 to 10 carbon atoms, cycloalkyl groups of from 5 to 8 carbon atoms, phenyl, 2-ethoxyethyl, 3-methoxybutyl, and a substituent of the formula: wherein each R′ is independently selected from the group consisting of: hydrogen and methyl, and R″ is selected from the group consisting of: alkyl of from 1 to 6 carbon atoms, alkenyl of from 2 to 6 carbon atoms, alkynyl of from 2 to 6 carbon atoms, cycloalkyl of from 3 to 8 carbon atoms, aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl, phenyl, and phenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, alkyl of 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms. 8. The composition according to claim 7, wherein R is alkyl of from 2 to 10 carbon atoms.9. The composition according to claim 8, wherein R is alkyl of from 2 to 8 carbon atoms.10. The composition according to claim 9, wherein R is selected from the group consisting of butyl, pentyl or octyl.11. The composition according to claim 10, wherein R is n-butyl.12. The composition according to claim 1 wherein said cyanoacrylate composition further comprises a biocompatible plasticizer.13. The composition according to claim 12, wherein said biocompatible plasticizer is dioctyl phthalate or acetyl tri-n-butyl citrate.14. The composition according to claim 13, wherein said cyanoacrylate adhesive composition further comprises a polymerization inhibitor.15. The composition according to claim 14, wherein said polymerization inhibitor is SO2.

이 특허에 인용된 특허 (10) 인용/피인용 타임라인 분석

Greff Richard J. (St. Pete Beach FL) Byram Michael M. (Colorado Springs CO), Cyanoacrylate compositions comprising an antimicrobial agent.
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Smith Stephen Jay, Medical dressing for application and maintenance of medication on body tissue.
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Greff Richard J. ; Lee Connie C., Methods and compositions for treating dermatoses.
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Askill Ian N. ; Greff Richard J. ; Byram Michael M. ; VanRyne Richard T., Methods for draping surgical incision sites.
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Tighe Patrick J. (Littleton CO) Byram Michael M. (Colorado Springs CO) Barley ; Jr. Leonard V. (Colorado Springs CO), Methods for inhibiting skin ulceration by use of cyanoacrylate adhesives.
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Barley ; Jr. Leonard V. (Colorado Springs CO) Tighe Patrick J. (Littleton CO) Greff Richard J. (Yorba Linda CA) Byram Michael M. (Colorado Springs CO), Methods for reducing skin irritation from artificial devices by use of cyanoacrylate adhesives.
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Barley ; Jr. Leonard V. (Colorado Springs CO), Methods for retarding blister formation by use of cyanoacrylate adhesives.
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Leonard V. Barley ; Linda M. Barley ; J. Royce Renfrow ; Patrick J. Tighe, Methods for treating non-suturable wounds by use of cyanoacrylate adhesives.
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Barley Linda M. (Colorado Springs CO) Renfrow J. Royce (Mt. Crested Butte CO) Byram Michael (Colorado Springs CO), Methods for treating suturable wounds by use of sutures and cyanoacrylate adhesives.
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Tighe Patrick J. (Littleton CO) Greff Richard J. (Yorba Linda CA) Byram Michael M. (Colorado Springs CO) Barley Leonard V. (Colorado Springs CO), Use of cyanoacrylate adhesives for providing a protective barrier film for the skin.
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이 특허를 인용한 특허 (16) 인용/피인용 타임라인 분석

Zhang, Sheng; Ruiz, Rafael, Adhesive compositions for medical use: single additive as both the thickening agent and the accelerator.
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Zhang, Sheng; Azevedo, Max; Ruiz, Sr., Rafael, Curing accelerator and method of making.
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Zhang, Sheng; Ruiz, Sr., Rafael; Azevedo, Max, Curing accelerator and method of making.
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Lee, Jeoung Soo; Webb, Charles Kenneth; Zimmerman, Robert; Ruiz, Sr., Rafael, Cyanoacrylate tissue adhesives.
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Lee, Jeoung Soo; Webb, Charles Kenneth; Zimmerman, Robert; Ruiz, Sr., Rafael; Zhang, Sheng, Cyanoacrylate tissue adhesives.
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Zhang, Sheng; Ruiz, Sr., Rafael; Azevedo, Max, Cyanoacrylate tissue adhesives with desirable permeability and tensile strength.
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Zhang, Sheng; Ruiz, Rafael, Cyanoacrylate-based liquid microbial sealant drape.
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Zhang, Sheng; Ruiz, Sr., Rafael, Low dose gamma sterilization of liquid adhesives.
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Zhang, Sheng; Ruiz, Rafael, Method of preparing adhesive compositions for medical use: single additive as both the thickening agent and the accelerator.
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Zhang, Sheng; Ruiz, Rafael, Stable and sterile tissue adhesive composition with a controlled high viscosity.
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Zhang, Sheng; Ruiz, Sr., Rafael; Phelps, Shannon, Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides.
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Zhang, Sheng; Ruiz, Sr., Rafael, Sterilized liquid compositions of cyanoacrylate monomer mixtures.
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Zhang, Sheng; Ruiz, Sr., Rafael, Sterilized liquid compositions of cyanoacrylate monomer mixtures.
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Myles, Ian Antheni; Datta, Sandip K., Use of gram negative species to treat atopic dermatitis.
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Myles, Ian Antheni; Datta, Sandip K., Use of gram negative species to treat atopic dermatitis.
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Coates, Anthony; Hu, Yanmin, Zidovudine combination therapies for treating microbial infections.
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[미국특허] Durable multi-component antibiotic formulation for topical use 원문보기

초록

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[미국특허] Durable multi-component antibiotic formulation for topical use 원문보기

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