초록

A novel vaccine for immunizing animals against Staphylococcus aureus-induced mastitis is disclosed. The vaccine is comprised of whole killed cells of S. aureus in a dosage effective to immunize an animal against the organism, in combination with a pharmaceutically acceptable carrier.

대표청구항 ▼

We claim: 1. A vaccine composition comprising (a) cells or cell lysates of a Type 5 Staphylococcus aureus strain wherein the cells express S. aureus Type 5 capsular antigen, (b) cells or cell lysates of a Type 8 S. aureus strain wherein the cells express S. aureus Type 8 capsular antigen, and (c)

We claim: 1. A vaccine composition comprising (a) cells or cell lysates of a Type 5 Staphylococcus aureus strain wherein the cells express S. aureus Type 5 capsular antigen, (b) cells or cell lysates of a Type 8 S. aureus strain wherein the cells express S. aureus Type 8 capsular antigen, and (c) cells or cell lysates of an unencapsulated S. aureus strain, identified as ATCC BAA-934, wherein the cells of said unencapsulated strain adhere to epithelial cells and carry an antigen that specifically binds with antibodies to S. aureus Type 336, and wherein the cells of said unencapsulated strain are not cells of S. aureus strain identified as ATCC55804, and a pharmaceutically or veterinarally acceptable carrier, diluent or excipient, and/or adjuvant. 2. The vaccine composition of claim 1, wherein the cells are formalin-killed. 3. The vaccine composition as claimed in claim 2 comprising an amount of the cells or the cell lysates of said three S. aureus strains effective to elicit an immune response specific for S. aureus in an animal. 4. The vaccine composition as claimed in claim 2 comprising an amount of the cells or the cell lysates of said three S. aureus strains effective to treat S. aureus-induced mastitis in an animal. 5. A method of treating S. aureus-induced mastitis in an animal comprising administering to said animal the vaccine composition of claim 2 in an amount effective to treat said mastitis in said animal. 6. A method for immunizing an animal against S. aureus comprising administering the vaccine composition of claim 2 to said animal in an amount effective to elicit an immune response specific for S. aureus in said animal. 7. The method of claim 5 or claim 6, wherein the animal is a bovine animal, a caprine animal, or an ovine animal.